Listening to Prozac


Book Description

The New York Times bestselling examination of the revolutionary antidepressant, with a new introduction and afterword reflecting on Prozac’s legacy and the latest medical research “Peter Kramer is an analyst of exceptional sensitivity and insight. To read his prose on virtually any subject is to be provoked, enthralled, illuminated.” —Joyce Carol Oates When antidepressants like Prozac first became available, Peter D. Kramer prescribed them, only to hear patients say that on medication, they felt different—less ill at ease, more like the person they had always imagined themselves to be. Referencing disciplines from cellular biology to animal ethology, Dr. Kramer worked to explain these reports. The result was Listening to Prozac, a revolutionary book that offered new perspectives on antidepressants, mood disorders, and our understanding of the self—and that became an instant national and international bestseller. In this thirtieth anniversary edition, Dr. Kramer looks back at the influence of his groundbreaking book, traces progress in the relevant sciences, follows trends in the use and public understanding of antidepressants, and assesses potential breakthroughs in the treatment of depression. The new introduction and afterword reinforce and reinvigorate a book that the New York Times called “originally insightful” and “intelligent and informative,” a window on a medicine that is “telling us new things about the chemistry of human character.”




Fluoxetine


Book Description

Fluoxetine, best known by the trade name Prozac®, unlike other psychotropic drugs whose effects were serendipitously stumbled upon, was the first developed for a precise mechanism of action, that is, the ability to selectively inhibit serotonin reuptake, based upon the theory that increasing the availability of serotonin would treat major depression. Once approved by the FDA in 1987, fluoxetine quickly became the most prescribed psychotropic drug worldwide and its success in improving mood disorders has triggered the development of a large number of congener molecules, commonly known as SSRIs after their purported mechanism of action. However, a quarter of a century after its development, the idea that fluoxetine asserts its positive behavioral effect through inhibition of serotonergic reuptake is not firmly established. This book reviews several preclinical and clinical reports suggesting that the pharmacological effects of fluoxetine may be mediated by means other than the regulation of serotonin, including the regulation of gene expression, modifying epigenetic mechanisms as well as modifying microRNAs. One of the most prominent mechanisms for the therapeutic relevance of fluoxetine relates to influencing neuroplasticity by enhancing neurotropic factors, including BDNF signaling and altering adult neurogenesis. The ability of fluoxetine to rapidly increase neurosteroid levels accounts for the fast anxiolytic effects of this drug. Fluoxetine action at sigma-1 receptor or modulating glutamatergic neurotransmission as well as the combination of fluoxetine with other psychotropic drugs is discussed in relation to its therapeutic effects. While fluoxetine was primarily prescribed as an antidepressant, this drug currently represents a treatment of choice for a broad spectrum of psychiatric disorders, including post-traumatic stress disorder and a range of anxiety disorders. This drug even possesses analgesic actions and is a valuable therapy for stroke. This book also highlights emerging evidence on the gender-specific effects of fluoxetine, its potential adverse features, including its addiction liability in combination with psychostimulants, and the impact of perinatal fluoxetine exposure.




Ordinarily Well


Book Description

Do antidepressants work, or are they glorified dummy pills? How can we tell? In Ordinarily Well, the celebrated psychiatrist and author Peter D. Kramer examines the growing controversy about the popular medications. A practicing doctor who trained as a psychotherapist and worked with pioneers in psychopharmacology, Kramer combines moving accounts of his patients’ dilemmas with an eye-opening history of drug research to cast antidepressants in a new light. Kramer homes in on the moment of clinical decision making: Prescribe or not? What evidence should doctors bring to bear? Using the wide range of reference that readers have come to expect in his books, he traces and critiques the growth of skepticism toward antidepressants. He examines industry-sponsored research, highlighting its shortcomings. He unpacks the “inside baseball” of psychiatry—statistics—and shows how findings can be skewed toward desired conclusions. Kramer never loses sight of patients. He writes with empathy about his clinical encounters over decades as he weighed treatments, analyzed trial results, and observed medications’ influence on his patients’ symptoms, behavior, careers, families, and quality of life. He updates his prior writing about the nature of depression as a destructive illness and the effect of antidepressants on traits like low self-worth. Crucially, he shows how antidepressants act in practice: less often as miracle cures than as useful, and welcome, tools for helping troubled people achieve an underrated goal—becoming ordinarily well.




TAKING ANTIDEPRESSANTS


Book Description

Antidepressants are the most commonly prescribed class of medications in this country - 190 million prescriptions per year have been written since 2005. Yet, consumers have few available resources to educate them in a fair, balanced fashion about starting and stopping antidepressants. People want to know if antidepressants are really safe, whether they are addictive, and how they may affect their personality. In this book, triple board-certified psychiatrist Dr. Michael Banov walks the reader through a personalized process to help them make the right choice about starting antidepressants, staying on antidepressants, and stopping antidepressants. He includes specific guidelines on how to safely reduce and ultimately stop taking antidepressants, if it is appropriate to do so. Readers will learn how antidepressant medications work, what they may experience while taking them, and will learn how to manage side effects or any residual or returning depression symptoms. Most books on depression take a biased view against antidepressant medication due to perceived dangers; this book finally provides a balanced, research-based resource for consumers who want the facts about taking antidepressants. The author holds readers' attention with case examples of characters they can relate to and interesting facts about depression, the brain, and mental health in general. The photos and illustrations in this book are black and white.




The Antidepressant Sourcebook


Book Description

In 1998, over 120 million prescriptions were written for antidepressants. That number is projected to rise by almost thirty million by the end of 2000. Despite this growing trend, many patients find that their doctors do not tell them all they need to know about the medications to make their treatments as successful as possible. The Antidepressant Sourcebook is the first place to turn for people taking antidepressants for the first time and for the millions who have already taken them. Here, in one concise reference, is all the reader needs to know, including what to talk about with the doctor, how to start and stop medications, and what to expect in the course of treatment. It is a written complement to what the doctor tells you. It answers every question a patient might have: How do I know if I'm on the right medication? Will my antidepressant interact with other medications I'm taking? Can I take it while pregnant? Will it change my personality? Do I need psychotherapy? If you or someone you love is taking antidepressants for depression, an anxiety disorder, or any other reason, your concerns will be addressed here. The Antidepressant Sourcebook is the most comprehensive primer you can own, offering hands-on advice and clear information. It's required reading for anyone who is taking or thinking about taking antidepressants.




The Antidepressant Survival Guide


Book Description

"Now patients can have the best of both worlds—freedom from depression and freedom from side effects. Dr. Robert Hedaya offers a wealth of wisdom drawn from years of clinical experience, research, and teaching. This book is a much-needed lantern in the darkness." —Norman Rosenthal, M.D., author of St. John's Wort: The Herbal Way to Feeling Good * Restore the vital vitamins, minerals, and hormones necessary to maintain good health. * Optimize your body's metabolic system. * Restore your ability to experience pleasure in life. An estimated twenty-five million Americans take antidepressants to combat depression, but most continue to cope with a host of debilitating side effects that equal, and sometimes outweigh, the medication's obvious benefits. Many doctors consider side effects such as weight gain, lethargy, and sexual dysfunction to be necessary evils. Finally, there is a doctor who refuses to trade a patient's total well-being for the treatment of depression. Clinical psychiatrist Robert J. Hedaya, M.D., has developed a comprehensive mind-body program to restore lost vitality and sex drive and control weight. A Washington Post bestseller in hardcover, his book offers a proven program of nutrition, exercise, stress reduction, and hormone supplementation that not only lessens the side effects of antidepressants but enhances their benefits as well. Now everyone can benefit from the prescription that has worked wonders for his own patients.




Discontinuing Antidepressant Medications


Book Description

One in six people in the US are currently taking psychotropic drugs. In 80% of cases, the medication is taken for long-term use and predominantly involves new-generation antidepressants, such as SSRIs (e.g. paroxetine) and SNRIs (e.g. venlafaxine). When patients want to stop taking these drugs and/or their physicians decide it is time for them to stop, substantial problems often can ensue. About 50% of patients experience withdrawal symptoms that do not necessarily subside after a few days or weeks and may be severe and debilitating. Physicians often do not know what to do in these situations. As a result, patients experiencing the anguish and mental pain of withdrawal syndromes are unlikely to receive appropriate medical attention. Discontinuing antidepressants is a highly technical challenge that requires specific strategies. This handbook guides clinicians through each clinical step (assessment; what the counter-indications would be for stopping or continuing; and how discontinuation can best be achieved). It provides a detailed account of the assessment and management strategies, with many case illustrations and clinical examples, drawing from the literature that is available and the extensive personal experience of the author.




Pharmacological Treatment of Mental Disorders in Primary Health Care


Book Description

This manual attempts to provide simple, adequate and evidence-based information to health care professionals in primary health care especially in low- and middle-income countries to be able to provide pharmacological treatment to persons with mental disorders. The manual contains basic principles of prescribing followed by chapters on medicines used in psychotic disorders; depressive disorders; bipolar disorders; generalized anxiety and sleep disorders; obsessive compulsive disorders and panic attacks; and alcohol and opioid dependence. The annexes provide information on evidence retrieval, assessment and synthesis and the peer view process.




Drugs in Pregnancy and Lactation


Book Description

An A-Z listing of drugs by generic name. Each monograph summarizes the known and/or possible effects of the drug on the fetus. It also summarizes the known/possible passage of the drug into the human breast milk. A careful and exhaustive summarization of the world literature as it relates to drugs in pregnancy and lacation. Each monograph contains six parts: generic US name, Pharmacologic class, Risk factor, Fetal risk summary, Breast feeding summary, References




The Emperor's New Drugs


Book Description

Do antidepressants work? Of course -- everyone knows it. Like his colleagues, Irving Kirsch, a researcher and clinical psychologist, for years referred patients to psychiatrists to have their depression treated with drugs before deciding to investigate for himself just how effective the drugs actually were. Over the course of the past fifteen years, however, Kirsch's research -- a thorough analysis of decades of Food and Drug Administration data -- has demonstrated that what everyone knew about antidepressants was wrong. Instead of treating depression with drugs, we've been treating it with suggestion. The Emperor's New Drugs makes an overwhelming case that what had seemed a cornerstone of psychiatric treatment is little more than a faulty consensus. But Kirsch does more than just criticize: he offers a path society can follow so that we stop popping pills and start proper treatment for depression.