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Pancreatic Cancer

Author : Douglas B. Evans

Publisher : Springer Science & Business Media

Page : 413 pages

File Size : 23,18 MB

Release : 2002

Category : Medical

ISBN : 0387951857

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Book Description

The MD Anderson Solid Tumor Oncology series presents cutting-edge surgical treatment and medical therapy for specific sites. This volume, Pancreatic Cancer, addresses epidemiology and molecular biology, inherited syndromes, staging, surgical techniques, multimodality therapy, and emerging therapies. The individual chapters focus on narrow, specific topics to produce a reference work of value to those interested in pancreatic cancer from a clinical and translational research perspective. A must-have for surgical oncologists and general surgeons.



Cancer Signaling

Author : Christoph Wagener

Publisher : John Wiley & Sons

Page : 357 pages

File Size : 28,16 MB

Release : 2016-08-12

Category : Science

ISBN : 352780045X

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Book Description

Cancer, which has become the second-most prevalent health issue globally, is essentially a malfunction of cell signaling. Understanding how the intricate signaling networks of cells and tissues allow cancer to thrive - and how they can be turned into potent weapons against it - is the key to managing cancer in the clinic and improving the outcome of cancer therapies. In their ground-breaking textbook, the authors provide a compelling story of how cancer works on the molecular level, and how targeted therapies using kinase inhibitors and other modulators of signaling pathways can contain and eventually cure it. The first part of the book gives an introduction into the cell and molecular biology of cancer, focusing on the key mechanisms of cancer formation. The second part of the book introduces the main signaling transduction mechanisms responsible for carcinogenesis and compares their function in healthy versus cancer cells. In contrast to the complexity of its topic, the text is easy to read. 32 specially prepared teaching videos on key concepts and pathways in cancer signaling are available online for users of the print edition and have been integrated into the text in the enhanced e-book edition.



Proteasome Inhibitors in Cancer Therapy

Author : Julian Adams

Publisher : Springer Science & Business Media

Page : 319 pages

File Size : 36,92 MB

Release : 2004-05-25

Category : Medical

ISBN : 1592597947

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Book Description

A panel of leading academic and pharmaceutical investigators takes stock of the remarkable work that has been accomplished to date with proteasome inhibitors in cancer, and examines emerging therapeutic possibilities. The topics range from a discussion of the chemistry and cell biology of the proteasome and the rationale for proteasome inhibitors in cancer to a review of current clinical trials underway. The discussion of rationales for testing proteasome inhibitors in cancer models covers the role of the proteasome in NF-kB activation, the combining of conventional chemotherapy and radiation with proteasome inhibition, notably PS-341, new proteasome methods of inhibiting viral maturation, and the role of protesome inhibition in the treatment of AIDS. The authors also document the development of bortezomib (VelcadeTM) in Phase I clinical trials and in a multicentered Phase II clinical trials in patients with relapsed and refractory myeloma.



Innovative Medicine

Author : Kazuwa Nakao

Publisher : Springer

Page : 330 pages

File Size : 28,45 MB

Release : 2015-10-13

Category : Science

ISBN : 4431556516

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Book Description

This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.



Signal Transduction in Cancer

Author : David A. Frank

Publisher : Springer Science & Business Media

Page : 358 pages

File Size : 22,66 MB

Release : 2002-12-31

Category : Medical

ISBN : 1402073402

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Book Description

One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously. This volume summarizes the current research on the role that signal transduction pathways play in the pathogenesis of cancer and how this knowledge may be used to develop the next generation of more effective and less toxic anticancer agents. Series Editor comments: "The biologic behavior of both normal and cancer cells is determined by critical signal transduction pathways. This text provides a comprehensive review of the field. Leading investigators discuss key molecules that may prove to be important diagnostic and/or therapeutic targets."



Biomarkers in Breast Cancer

Author : Giampietro Gasparini

Publisher : Springer Science & Business Media

Page : 335 pages

File Size : 37,31 MB

Release : 2008-01-17

Category : Medical

ISBN : 159259915X

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Book Description

Expert laboratory and clinical researchers from around the world review how to design and evaluate studies of tumor markers and examine their use in breast cancer patients. The authors cover both the major advances in sophisticated molecular methods and the state-of-the-art in conventional prognostic and predictive indicators. Among the topics discussed are the relevance of rigorous study design and guidelines for the validation studies of new biomarkers, gene expression profiling by tissue microarrays, adjuvant systemic therapy, and the use of estrogen, progesterone, and epidermal growth factor receptors as both prognostic and predictive indicators. Highlights include the evaluation of HER2 and EGFR family members, of p53, and of UPA/PAI-1; the detection of rare cells in blood and marrow; and the detection and analysis of soluble, circulating markers.



The Theory of the Gene

Author : Thomas Hunt Morgan

Publisher :

Page : 392 pages

File Size : 31,45 MB

Release : 1926

Category : Genetics

ISBN :

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Book Description



Stem Cells – From Hype to Real Hope

Author : Khawaja Husnain Haider

Publisher : Walter de Gruyter GmbH & Co KG

Page : 220 pages

File Size : 14,54 MB

Release : 2018-12-17

Category : Medical

ISBN : 3110587041

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Book Description

This book is a compilation of the bench experience of leading experts from various research labs involved in the cutting edge area of research. The authors describe the use of stem cells both as part of the combinatorial therapeutic intervention approach and as tools (disease model) during drug development, highlighting the shift from a conventional symptomatic treatment strategy to addressing the root cause of the disease process. The book is a continuum of the previously published book entitled "Stem Cells: from Drug to Drug Discovery" which was published in 2017.



Cancer Cell Signaling

Author : Kasirajan Ayyanathan

Publisher : CRC Press

Page : 402 pages

File Size : 38,35 MB

Release : 2014-06-20

Category : Medical

ISBN : 1482299453

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Book Description

This title includes a number of Open Access chapters.Cell signaling is a field that studies how cells communicate to control basic activities and respond to their environment. When looking specifically at cancer cells, researchers can gain a better understanding of cancer on a cellular level, an understanding that may have implications for developi



Notch Signaling

Author : Hugo J. Bellen

Publisher : Humana Press

Page : 0 pages

File Size : 43,66 MB

Release : 2014-07-23

Category : Science

ISBN : 9781493911387

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Book Description

Notch Signaling: Methods and Protocols focuses on molecular, biochemical and bioinformatics aspects of Notch signaling. Chapters analyze the Notch interactome, post-translational modifications of Notch, ligand binding assays, methods to assess proteolytic cleavage and transcriptional targets. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Notch Signaling: Methods and Protocols is a valuable contribution to hundreds of labs and thousands of scientists who pursue this research area with vigor.