Author : OECD
Publisher : OECD Publishing
Page : 25 pages
File Size : 10,70 MB
Release : 2014-09-26
Category :
ISBN : 9264224173
The in vivo alkaline single cell gel electrophoresis assay, also called alkaline Comet Assay is a method measuring DNA strand breaks in eukaryotic cells.
Author : OECD
Publisher : OECD Publishing
Page : 27 pages
File Size : 41,45 MB
Release : 2016-07-29
Category :
ISBN : 9264264884
The in vivo alkaline single cell gel electrophoresis assay, also called alkaline Comet Assay is a method measuring DNA strand breaks in eukaryotic cells.
Author : Ray Proudlock
Publisher : Academic Press
Page : 458 pages
File Size : 47,9 MB
Release : 2016-05-28
Category : Medical
ISBN : 0128010061
Genetic Toxicology Testing: A Laboratory Manual presents a practical guide to genetic toxicology testing of chemicals in a GLP environment. The most commonly used assays are described, from laboratory and test design to results analysis. In a methodical manner, individual test methods are described step-by-step, along with equipment, suggested suppliers, recipes for reagents, and evaluation criteria. An invaluable resource in the lab, this book will help to troubleshoot any assay problems you may encounter to optimise quality and efficiency in your genetic toxicology tests. Genetic Toxicology Testing: A Laboratory Manual is an essential reference for those new to the genetic toxicology laboratory, or anyone involved in setting up their own. - Offers practical and consistent guidance on the most commonly-performed tests and procedures in a genetic toxicology lab - Describes standard genetic toxicology assays, their methodology, reagents, suppliers, and analysis of their results - Includes guidance on general approaches: formulation for in vitro assays, study monitoring, and Good Laboratory Practice (GLP) - Serves as an essential reference for those new to the genetic toxicology laboratory, or anyone involved in setting up their own lab
Author : Alok Dhawan
Publisher : Humana Press
Page : 0 pages
File Size : 39,63 MB
Release : 2013-07-30
Category : Medical
ISBN : 9781627035286
Genetic toxicology is recognized by geneticists and researchers concerned with the genetic impact of man-made chemicals. In Genotoxicity Assessment: Methods and Protocols, expert researchers in the field provide comprehensive genetic toxicology protocols. These include in vitro and in vivo protocols on mutation assays, cytogenetic techniques, and primary DNA damage, assays in alternate to animal models, and updated ICH guidelines. Written in the highly successful Methods in Molecular Biology series format, the chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as key tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Genotoxicity Assessment: Methods and Protocols seeks to aid research students and scientists working in regulatory toxicology as well as biomedical, biochemical and pharmaceutical sciences.
Author : Marcelo Larramendy
Publisher : BoD – Books on Demand
Page : 280 pages
File Size : 47,71 MB
Release : 2016-06-16
Category : Science
ISBN : 9535124013
This book, Environmental Health Risk - Hazardous Factors to Living Species, is intended to provide a set of practical discussions and relevant tools for making risky decisions that require actions to reduce environmental health risk against environmental factors that may adversely impact human health or ecological balances. We aimed to compile information from diverse sources into a single volume to give some real examples extending concepts of those hazardous factors to living species that may stimulate new research ideas and trends in the relevant fields.
Author :
Publisher :
Page : 584 pages
File Size : 17,51 MB
Release : 2007
Category : Lead
ISBN :
Author : OECD
Publisher : OECD Publishing
Page : 23 pages
File Size : 25,81 MB
Release : 2010-07-23
Category :
ISBN : 9264091017
The in vitro micronucleus test is a genotoxicity test for the detection of micronuclei in the cytoplasm of interphase cells. Micronuclei may originate from acentric chromosome fragments (i.e. lacking a centromere), or whole chromosomes that are ...
Author : United States. Public Health Service. Office of the Surgeon General
Publisher :
Page : 728 pages
File Size : 25,57 MB
Release : 2010
Category : Government publications
ISBN :
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Author : Albert P. Li
Publisher : CRC Press
Page : 508 pages
File Size : 46,53 MB
Release : 1991-03-27
Category : Medical
ISBN : 9780849388156
Genetic Toxicology is a comprehensive book covering the historical perspective of genetic toxicology; basic mechanisms of mutations and chromosomal effects; health consequences of genetic damage, including cancer and inheritable mutations; properties of physical, chemical, and biological mutagens; risk assessment of human exposure to genotoxicants; and the current position of some government regulatory agencies in the United States on the issues of genetic toxicology. The book will be a useful reference for students and researchers in toxicology, genetics, cancer biology, and medicine who are interested in the basic and applied principles of genetic toxicology. It will also benefit industrial toxicologists, products registration specialists, and government regulatory specialists with responsibility for the safety evaluation of industrial and environmental agents.
Author : IARC Working Group on the Evaluation of Carcinogenic Risks to Humans
Publisher : World Health Organization
Page : 434 pages
File Size : 24,71 MB
Release : 2002
Category : Medical
ISBN : 9283212819
"This publication represents the views and expert opinions of an IARC working group on the evaluation of carcinogenic risks to humans, which met in Lyon, 9-16 October 2001."
