Book Description
Nuclear magnetic resonance spectroscopy (NMR) is a technique that uses the magnetic properties of atomic nuclei to obtain information about the structure and properties of molecules. Proton and Carbon NMR, focusing on 1H and 13C, constitute the most powerful spectroscopic method for structure determination of Organic molecules. Application of this methodology to the assignment of absolute configuration was initiated in the late sixties and now is a well-established method that allows the rapid determination of the absolute configuration of more than one dozen different classes of mono-, bi-, and trifunctional organic compounds. Its simplicity requires the derivatization of the compound with a chiral arylalkoxyacetic acid, and examination of their 1H- and/or 13C-NMR spectra. In The Assignment of the Absolute Configuration by NMR using Chiral Derivatizing Agents: A Practical Guide, Professor Ricardo Riguera and coauthors organize this cutting-edge NMR research, offering a short and usable guide that introduces the reader to the research with a plethora of details and examples. The book briefly explains the theoretical aspects behind this methodology, dedicating most of its space to covering the practical aspects of the assignment, as well as the selection of the most adequate auxiliary reagent and the single or double derivatization, the use of resins etc. Examples and spectra taken from the authors' own experiments are included to illustrate the methodology. Upper-level undergraduates, graduate students, and chemical and pharmaceutical researchers will find this guide useful for their studies.
