Malaria Vaccines: The Continuing Quest


Book Description

In 2013, 200 million people were infected with malaria, resulting in over 584,000 deaths, with the potential to affect over half the world's population. Such is the widespread nature of malaria that it is increasingly believed only a vaccine will lead to its eradication.Although the first attempt at a vaccine was made a century ago, it is only in the last 30 years that real progress in testing has been made, in the hope of discovering a molecule that can provide long-lasting protection against the disease. In July 2015, GlaxoSmithKline (GSK) announced that after 30 years of research it had received the green light from the European Medicines Agency for the world's first malaria vaccine, RTS, S, for use in African children aged 6 weeks to 17 months.This book chronicles the development of RTS, S — done in collaboration with the Walter Reed Army Institute for Research, the PATH Malaria Vaccine Initiative (MVI) and funded in part by the Bill and Melinda Gates Foundation — as well as previous candidate vaccines. It also focusses on the continuing quest to find more effective vaccines against this continuing health crisis. Finally, it provides an easily understood background on recombinant DNA and monoclonal antibodies and places them in perspective to their contributions to malaria vaccine development.This book serves as a convenient and easily accessible source of information for students, teachers, microbiologists, parasitologists, physicians, clinicians and research funders.




The Continuing Quest for Missile Defense


Book Description

For almost three quarters of a century, the United States has spent billions of dollars and countless person-hours in the pursuit of a national missile defense system that would protect the country from intercontinental ballistic missiles (ICBM) carrying nuclear warheads. The system currently in place consists of 44 long-range antiballistic missiles stationed in Alaska and California to protect the United States from a possible nuclear weapon carrying ICBM attack from North Korea. After all this effort, this systemis still imperfect, being successful only 10 out of 18 tests. This book will provide an historical description of past efforts in national missile defenses to understand the technical difficulties involved. It will also explain how national security concerns, the evolving international environment, and the complexities of US politics have all affected the story. The book will also describe the current systems in place to protect allies and troops in the field from the threat of shorter range missiles. Finally, the book will describe the current US vision for the future of missile defenses and provide some suggestions for alternative paths.




Cam's Quest


Book Description

Seventeen-year-old Cam realizes that to plan his future, he must untangle the mysteries of his past. For as long as he can remember, he has served as the apprentice to Melikar, the wizard. Now released from Melikars service, its time to seek out the truth of his birth. In the meantime, Princess Quinn-his princess-must choose a husband. Because of his station, Cam can only stand by and watch-or seek his future in the outer world. In this sequel to Princess Nevermore, secrets are revealed that ensure a future that neither Quinn nor Cam had dared to imagine.




UFO


Book Description

Explores the latest findings of a wide range of experts in every relevant field, from meteorology to aeronautics.




Adapting Minds


Book Description

Was human nature designed by natural selection in the Pleistocene epoch? The dominant view in evolutionary psychology holds that it was—that our psychological adaptations were designed tens of thousands of years ago to solve problems faced by our hunter-gatherer ancestors. In this provocative and lively book, David Buller examines in detail the major claims of evolutionary psychology—the paradigm popularized by Steven Pinker in The Blank Slate and by David Buss in The Evolution of Desire—and rejects them all. This does not mean that we cannot apply evolutionary theory to human psychology, says Buller, but that the conventional wisdom in evolutionary psychology is misguided. Evolutionary psychology employs a kind of reverse engineering to explain the evolved design of the mind, figuring out the adaptive problems our ancestors faced and then inferring the psychological adaptations that evolved to solve them. In the carefully argued central chapters of Adapting Minds, Buller scrutinizes several of evolutionary psychology's most highly publicized "discoveries," including "discriminative parental solicitude" (the idea that stepparents abuse their stepchildren at a higher rate than genetic parents abuse their biological children). Drawing on a wide range of empirical research, including his own large-scale study of child abuse, he shows that none is actually supported by the evidence. Buller argues that our minds are not adapted to the Pleistocene, but, like the immune system, are continually adapting, over both evolutionary time and individual lifetimes. We must move beyond the reigning orthodoxy of evolutionary psychology to reach an accurate understanding of how human psychology is influenced by evolution. When we do, Buller claims, we will abandon not only the quest for human nature but the very idea of human nature itself.




Jesus, Justice, and the Reign of God


Book Description

By building on his view of Jesus first developed in Parables as Subversive Speech, William Herzog II argues that Jesus is intensely interested in the social, political, and economic well-being of humanity. He examines the conflict stories, exorcisms/healings, and the passion narrative to develop his thesis and, in the final chapter, he interprets the resurrection in light of this viewpoint.




Mystic Quest


Book Description

Thrice upon a time, three worlds were in peril... New York Times bestselling author Tracy Hickman and Dragonlance cocreator Laura Hickman present the continuing story of their monumental, enthralling epic fantasy Thrice upon a time, three champions will find one destiny... In the course of more than two decades, Galen Arvad's tiny band of outlaw Mystics has grown into a nation of secret clans, despite fierce persecution by the Pir theocracy and the dragons that have enslaved humanity. On another world, the faery Dwynwyn saved her people by raising an army of the dead, but now none of the corpses can rest...and the sheer number of their tormented legions threatens the faery kingdoms. While on the third world, the tyrannical King Mimic's domination is threatened by a warrior maiden whose thirst for conquest exceeds his own. Yet through the magic of the dreams that link their worlds, a new wind blows, beckoning each of them into unknown lands with the promise of salvation, sanctuary, and power. For Galen's war-weary son, Caelith, the slender hope takes the form of a stranger's vow to lead him and his people to the sanctuary of a lost empire-the legendary ancestral home of the Mystics. Dwynwyn seeks salvation of her people through a small fellowship of Fae who must journey to a distant land of unquenchable horror-where their truth can bring peace to the living and the dead. As for the wizard-goblin Thux, newly and unwillingly appointed Technomancer to King Mimic, his journey to the Ogre citadel may bring him to the height of power and danger-if his own allies do not kill him first. Now three bands of heroes embark on odysseys beset by outer tragedy and inner betrayal. For each to survive, all must succeed-for all three worlds face the same cunning evil...




The Legacy of Raúl Prebisch


Book Description

This volume honors Raúl Prebisch's contributions to economic thought and uses his 1970 report Change and Development: Latin America's Great Task as a point of departure for analyzing trends in the region in the 1970s and 1980s. This volume comprises a collection of the papers presented at the seminar "Latin American Thought: Past, Present and Future," convened by the Inter-American Development Bank in Washington, D.C. on November 14 and 15, 1991. Several factors influenced the selection of both the topic and the institution that hosted this seminar.




Multi-Agent Oriented Programming


Book Description

The main concepts and techniques of multi-agent oriented programming, which supports the multi-agent systems paradigm at the programming level. A multi-agent system is an organized ensemble of autonomous, intelligent, goal-oriented entities called agents, communicating with each other and interacting within an environment. This book introduces the main concepts and techniques of multi-agent oriented programming, (MAOP) which supports the multi-agent systems paradigm at the programming level. MAOP provides a structured approach based on three integrated dimensions, which the book examines in detail: the agent dimension, used to design the individual (interacting) entities; the environment dimension, which allows the development of shared resources and connections to the real world; and the organization dimension, which structures the interactions among the autonomous agents and the shared environment.




The Continued Exercise of Reason


Book Description

Lectures, many never before published, that offer insights into the early thinking of the mathematician and polymath George Boole. George Boole (1815–1864), remembered by history as the developer of an eponymous form of algebraic logic, can be considered a pioneer of the information age not only because of the application of Boolean logic to the design of switching circuits but also because of his contributions to the mass distribution of knowledge. In the classroom and the lecture hall, Boole interpreted recent discoveries and debates in a wide range of fields for a general audience. This collection of lectures, many never before published, offers insights into the early thinking of an innovative mathematician and intellectual polymath. Bertrand Russell claimed that “pure mathematics was discovered by Boole,” but before Boole joined a university faculty as professor of mathematics in 1849, advocacy for science and education occupied much of his time. He was deeply committed to the Victorian ideals of social improvement and cooperation, arguing that “the continued exercise of reason” joined all disciplines in a common endeavor. In these talks, Boole discusses the genius of Isaac Newton; ancient mythologies and forms of worship; the possibility of other inhabited planets in the universe; the virtues of free and open access to knowledge; the benefits of leisure; the quality of education; the origin of scientific knowledge; and the fellowship of intellectual culture. The lectures are accompanied by a substantive introduction by Brendan Dooley, the editor of the volume, that supplies biographical and historical context.