Author : Ling Liu
Publisher : Frontiers Media SA
Page : 161 pages
File Size : 44,37 MB
Release : 2023-08-30
Category : Science
ISBN : 2832532756
Author : Atta-ur Rahman
Publisher : Elsevier
Page : 436 pages
File Size : 42,12 MB
Release : 2016-09-30
Category : Science
ISBN : 0444637567
Studies in Natural Products Chemistry: Bioactive Natural Products (Part XIII) is the latest in a series that covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting-edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis, and pharmacology of a diverse array of bioactive natural products. Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to quickly isolate and determine the structures and biological activity of natural products, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry. Focuses on the chemistry of bioactive natural products Contains contributions by leading authorities in the field Presents sources of new pharmacophores
Author :
Publisher : Elsevier
Page : 436 pages
File Size : 42,99 MB
Release : 2016-09-06
Category : Science
ISBN : 0444636099
Studies in Natural Products Chemistry: Bioactive Natural Products (Part XII) is the latest in a series that covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting-edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis, and pharmacology of a diverse array of bioactive natural products. Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to quickly isolate and determine the structures and biological activity of natural products, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry. Focuses on the chemistry of bioactive natural products Contains contributions by leading authorities in the field Presents sources of new pharmacophores
Author : Joginder Singh
Publisher : Springer Nature
Page : 733 pages
File Size : 43,52 MB
Release : 2020-04-30
Category : Medical
ISBN : 9811513945
This book highlights different natural products that are derived from the plants and microbes that have shown potential as the lead compounds against infectious diseases and cancer. Natural products represent an untapped source of strikingly diverse chemotypes with novel mechanisms of action and the potential to serve as anticancer and anti-infective agents. The book discusses a range of biotechnologically valuable bioactive compounds and secondary metabolites that have been derived from plant and microorganisms from various ecological niches. It also reviews the latest developments in the field of genomics, bioinformatics and industrial fermentation for harnessing the microbial products for commercial applications. In turn, the book’s closing section reviews important biotechnological applications of various natural products. Combining the expertise of specialists in this field, the book’s goal is to promote the further investigation of natural sources for the development of standardized, safe and effective therapies.
Author : Mansoor Ahmad
Publisher :
Page : 0 pages
File Size : 10,88 MB
Release : 2011
Category :
ISBN :
Author : Steven M. Colegate
Publisher : CRC Press
Page : 0 pages
File Size : 40,22 MB
Release : 2007-12-14
Category : Science
ISBN : 9780849372582
Bioactive natural products are proving to be a rich source of novel therapeutics to both protect against and combat diseases, as well as serve as lead compounds in crop protection. Following the successful format of the first edition, this volume brings together collective research from many new contributors and emphasizes the rationale behind the successful detection, isolation, and structure determination of specific compounds. The text encompasses a diverse range of techniques that can be applied to terrestrial and aquatic sources. It also allows you to understand how source material can be selected to enhance your opportunity to discover and utilize novel bioactive natural products. New to the Second Edition— · Advances in the application of NMR spectroscopy and mass spectrometry, bioactive chemical detection and extraction, dereplication, and novel bioassay development · New case studies and illustrations that demonstrate the practical applications of specific techniques · A group of new contributors presenting research from their own laboratories that emphasize both the philosophy and rationale behind detection, isolation, and structural determination Following an overview of natural product chemistry techniques and approaches, many new chapters discuss selection of source material, quantitative NMR, high speed counter-current chromatography, dereplication of extracts, and methods to determine the stereochemistry of bioactive natural products. Examinations of new technologies including LC-NMR, biosensors, and biofingerprinting accompany discussions on the search for specific activities in anticancer and antimalarial applications, seed germination stimulation, and mammalian toxicity. With the participation from active researchers, this definitive work supplies a vital extension and an enduring contribution to the science and art of bioactive natural product detection, isolation, and structural determination.
Author : Atta-ur Rahman
Publisher : Elsevier
Page : 0 pages
File Size : 30,54 MB
Release : 2022-09-29
Category : Science
ISBN : 9780323912501
Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry. Studies in Natural Products Chemistry covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products.
Author : Danielle Yee
Publisher :
Page : 298 pages
File Size : 34,42 MB
Release : 2022
Category :
ISBN :
Natural products from plants, fungi, and bacteria are an invaluable source of bioactive compounds with numerous applications in the pharmaceutical industry and agriculture. Metabolic engineering can be utilized to increase the yield of these valuable compounds and their precursors. Meanwhile, genome mining can be employed to discover novel natural product scaffolds and unique functional groups that can confer various biological activities to the resulting compound. During my doctoral research, I have performed work in both of these fields to engineer yeast for precursor production of the pharmaceutically relevant monoterpene indole alkaloids as well as elucidate the biosynthesis of new natural products from several fungal species. Strategies for yeast metabolic engineering included targeting the production of monoterpene precursors to the mitochondria and further mitochondrial engineering through deletion of transporter genes and transcription factor overexpression. Genome mining efforts led to the discovery of new compounds with a unique hybrid terpene and amino acid derived scaffold as well as a new family of biosynthetic core genes that form arginine containing cyclodipeptides. Study of these pathways also resulted in the identification of enzymes that can perform novel reactions to create greater chemical diversity. These genes can expand the query database to mine for more compounds with novel structures.
Author : Hanna Mazur-Marzec
Publisher :
Page : 172 pages
File Size : 16,30 MB
Release : 2021
Category :
ISBN : 9783036506210
For this Special Issue book, ten papers focusing on novel bioactive molecules from different marine microorganisms, including fungi, cyanobacteria, actinobacteria and diatoms, were selected. The isolated biomolecules represent different structures and showed anticancer, antiviral, antifungal, antibacterial, anti-inflammatory and enzyme-inhibiting activities. One of the papers is a review article on microviridins, a class of bioactive cyanobacterial peptides.
Author : Joginder Singh
Publisher : Springer Nature
Page : 307 pages
File Size : 20,35 MB
Release : 2020-05-11
Category : Medical
ISBN : 9811530246
This book discusses various aspects of bioactive natural products employed in the agrochemical and agriculture sectors. It covers the use of plants, microorganisms, and microbial metabolites as eco-friendly, cost-effective, and sustainable alternatives to chemicals in the field of agriculture. Written by active researchers and academics, the book highlights state-of-art products in the field, as well as the gaps, challenges, and obstacles associated with the use of plants, microbes and their products. Given its scope, it is a valuable resource for the scientific community and professionals in enterprises wanting insights into the latest developments and advances in the context of biological products, including their applications, traditional uses, modern practices, and strategies to harness their full potential.
