The Evolution of the Human Placenta


Book Description

Power and Schulkin reveal the amazing evolution of the human placenta—and in so doing show how each of our lives began. As the active interface of the most biologically intimate connection between two living organisms, a mother and her fetus, the placenta is crucial to human evolution and survival. Michael L. Power and Jay Schulkin explore the more than 100 million years of evolution that led to the human placenta and, in so doing, they help unravel the mysteries of human life's first moments. Starting with some of the earliest events that have influenced the path of placental evolution in mammals and progressing to the specifics of the human placenta, this book examines modern gestation within an evolutionary framework. Human beings are a successful species and our numbers have increased dramatically since our earliest days on Earth. However, human fetal development is fraught with poor outcomes for both the mother and fetus that appear to be, if not unique, far more common in humans than in other mammals. High rates of early pregnancy loss, nausea and vomiting during pregnancy, preeclampsia and related maternal hypertension, and preterm birth are rare or absent in other mammals yet not unusual in humans. Power and Schulkin explain why this apparent contradiction exists and address such topics as how the placenta regulates and coordinates the metabolism, growth, and development of both mother and fetus, the placenta’s role in protecting a fetus from the mother’s immune system, and placental diseases. In the process, they reveal the vital importance of this organ—which is composed mostly of fetal cells—for us as individuals and as a species.




The Human Placenta


Book Description

The placenta is fascinating and complex. Basically foreign to the maternal body, it can be thought of as an organ transplanted onto the mother's host tissue. As such it embodies all the principles of tissue acceptance and rejection. Many of the risks of pregnancy and labor have now been eliminated and the placenta is likely to be at the root of many of the dangers to the unborn child that remain. A breakdown of the relationship between the placenta and the maternal tissue may turn out to be the cause of the majority of early lost pregnancies.




Placental Bed Disorders


Book Description

It is now recognized that defective placentation in the human is a cause of many pregnancy complications, such as spontaneous abortion, preterm labor and delivery, pre-eclampsia, intrauterine growth restriction, fetal death and abruptio placenta. These clinical disorders can often have long-term consequences into adulthood, causing cardiovascular disease, obesity and diabetes for the newborn as well as an increased risk of premature death in the mother. This is the first book to be entirely focused on the placental bed, bringing together the results of basic and clinical research in cell biology, immunology, endocrinology, pathology, genetics and imaging to consolidate in a single, informative source for investigators and clinicians. Its core aim is to explore new approaches and improve current clinical practice. This is essential reading for clinicians in obstetric, cardiovascular and reproductive medicine.




Benirschke's Pathology of the Human Placenta


Book Description

This book had its beginning in 1967 when Shirley G. Driscoll and Kurt Benirschke wrote in English the volume on placental pathology for the Henke-Lubarsch, the noted German Handbook of Pathology. There seemed to be a need for wider distribution of the text and it was reprinted by Springer Verlag, New York, essentially the only book available devoted just to the human placenta. Dr. Benirschke authored 5 subsequent editions in collaboration with Peter Kaufmann, Rebecca Baergen and Graham Burton in 1990 (2nd edition), 1995 (3rd edition), 2000 (4th edition), 2006 (5th edition) and 2012 (6th edition). In the early editions, the most important material was in a larger font than the extensive review of exceptions and the discussion in the literature. Since 1967, many other shorter placenta books have been published in English, French and German. None of these have included the breadth of discussion or the voluminous references which includes details of many historic articles, not readily available. Interest in the placenta has wildly expanded over the intervening 50+ years with the vast majority of Pathologists, Obstetricians and Pediatricians recognizing its value. In addition, there are now quite a few new journals, societies and meetings devoted to the placenta in both clinical and research areas. The interest extends into areas of study well beyond the realm of anatomic pathology. The 7th edition will, of necessity, differ from the prior editions which Dr. Benirschke wrote largely himself at first, and later with the help of the above noted co-authors. It will now be an international multi-authored book with nearly 40 contributors revising one or more chapters. The explosion of new information as necessitating some reordering of chapters and adding completely new chapters including Chapters 31 and 32, “Innovations in Placental Pathology” and “Imaging in Placental Pathology”. Dr. Burton’s section has been extensively edited, as well. The editors gave the new authors considerable latitude in how to write the new and/or edited chapters. Many of the revised chapters retain much of Dr. Benirschke’s anecdotal information as well as the voluminous references. Others are more modern in their approach. All contain substantial new references and current information. It is our hope that Benirschke’s Pathology of the Human Placenta will remain as a mainstay reference in placental pathology. It aims to help readers gain a broad understanding of how placental architecture is shaped during normal development, with a view to appreciating how this may be perturbed in complications of pregnancy.




The Placenta and Human Developmental Programming


Book Description

Developmental programming is a rapidly advancing discipline of great importance to basic scientists and health professionals alike. This text integrates, for the first time, contributions from world experts to explore the role of the placenta in developmental programming. The book considers the materno-fetal supply line, and how perturbations of placental development impact on its functional capacity. Chapters examine ways in which environmental, immunological and vascular insults regulate expression of conventional and imprinted genes, along with their impact on placental shape and size, transport, metabolism and endocrine function. Research in animal models is integrated with human clinical and epidemiological data, and questions for future research are identified. Transcripts of discussions between the authors allow readers to engage with controversial issues. Essential reading for researchers in placental biology and developmental programming, as well as specialists and trainees in the wider field of reproductive medicine.




Patterns of Human Growth


Book Description

A revised edition of an established text on human growth and development from an anthropological and evolutionary perspective.




Placentation in Mammals


Book Description

The present volume of the book series Advances in Anatomy, Embryology and Cell Biology brings together current reviews from leading experts to address the diversity of placentation by which species establish and maintain pregnancy. Development of viviparity and placentation in rodents, dogs, pigs, cattle, horses, marsupials, primates and elephants are discussed. The development of viviparity in mammals, including some invertebrate species, required the adaptation of the placenta to serve as a functional conduit for interplay between the semiallograftic fetus with the maternal uterus. Although the ‘placenta’ protects the fetus from maternal immune rejection and provides oxygen and nutrient flow to support it to term across all the species, structural differentiation of this fetal-maternal interface can vary from simple to very complex. E.C. Amoroso contributed greatly to our early understanding and knowledge of placentation across a great variety of species. His work on placentation provides numerous illustrations and histological sections which are used for teaching and stimulating research today. With this book, we want to pay tribute to his lifetime contributions to the field by reviewing our current understanding of the development of viviparity and placentation in different species. The book is written for researchers, physicians and medical students working in the field of reproductive science or with an interest in placentation and viviparity.




Oxford Textbook of Obstetric Anaesthesia


Book Description

This textbook provides an up-to-date summary of the scientific basis, assessment for and provision of anaesthesia throughout pregnancy and labour. It is divided into nine sections including physiology, assessment, complications and systemic disease.




Exploring the Biological Contributions to Human Health


Book Description

It's obvious why only men develop prostate cancer and why only women get ovarian cancer. But it is not obvious why women are more likely to recover language ability after a stroke than men or why women are more apt to develop autoimmune diseases such as lupus. Sex differences in health throughout the lifespan have been documented. Exploring the Biological Contributions to Human Health begins to snap the pieces of the puzzle into place so that this knowledge can be used to improve health for both sexes. From behavior and cognition to metabolism and response to chemicals and infectious organisms, this book explores the health impact of sex (being male or female, according to reproductive organs and chromosomes) and gender (one's sense of self as male or female in society). Exploring the Biological Contributions to Human Health discusses basic biochemical differences in the cells of males and females and health variability between the sexes from conception throughout life. The book identifies key research needs and opportunities and addresses barriers to research. Exploring the Biological Contributions to Human Health will be important to health policy makers, basic, applied, and clinical researchers, educators, providers, and journalists-while being very accessible to interested lay readers.




Life's Vital Link


Book Description

How does the foetus - a foreign body - survive inside the mother? The placenta is the extraordinary organ that allows this to happen; but this remarkable feat of evolution is only just being fully appreciated by science. Y.W. Loke explores the fascinating nature of the placenta and what it can tell us about evolution, development, and genetics.