› › The Fos And Jun Families Of Transcription Factors

The FOS and JUN Families of Transcription Factors

Author : Peter E. Angel

Publisher : CRC Press

Page : 464 pages

File Size : 18,19 MB

Release : 2017-11-22

Category : Medical

ISBN : 1351357115

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Book Description

This book introduces and analyzes the crucial role of AP-1 in cell growth, proliferation, differentiation, and apoptosis. AP-1 is the endpoint of several pathways of signal transduction, including one that triggers cancerous growth. The control of its activity is an issue of basic science, cancer therapy, and other diseases. The chapters provide multiple viewpoints of the emerging data on AP-1, including its role as a factor regulating genes involved in the metastatic properties of cancer, as a factor that interacts with viral gene products, and as a part of the mechanism by which steroid and retinoic acid receptors function as anti-inflammatory proteins.



Transcriptional Control of Neural Crest Development

Author : Brian L. Nelms

Publisher : Morgan & Claypool Publishers

Page : 227 pages

File Size : 34,95 MB

Release : 2010

Category : Science

ISBN : 161504048X

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Book Description

The neural crest is a remarkable embryonic population of cells found only in vertebrates and has the potential to give rise to many different cell types contributing throughout the body. These derivatives range from the mesenchymal bone and cartilage comprising the facial skeleton, to neuronal derivatives of the peripheral sensory and autonomic nervous systems, to melanocytes throughout the body, and to smooth muscle of the great arteries of the heart. For these cells to correctly progress from an unspecifi ed, nonmigratory population to a wide array of dynamic, differentiated cell types-some of which retain stem cell characteristics presumably to replenish these derivatives-requires a complex network of molecular switches to control the gene programs giving these cells their defi ning structural, enzymatic, migratory, and signaling capacities. This review will bring together current knowledge of neural crest-specifi c transcription factors governing these progressions throughout the course of development. A more thorough understanding of the mechanisms of transcriptional control in differentiation will aid in strategies designed to push undifferentiated cells toward a particular lineage, and unraveling these processes will help toward reprogramming cells from a differentiated to a more naive state. Table of Contents: Introduction / AP Genes / bHLH Genes / ETS Genes / Fox Genes / Homeobox Genes / Hox Genes / Lim Genes / Pax Genes / POU Domain Genes / RAR/RXR Genes / Smad Genes / Sox Genes / Zinc Finger Genes / Other Miscellaneous Genes / References / Author Biographies



Handbook of Oxidants and Antioxidants in Exercise

Author : C. Sen

Publisher : Elsevier

Page : 1219 pages

File Size : 28,49 MB

Release : 2000-02-16

Category : Science

ISBN : 0080538290

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Book Description

Interest in the science of exercise dates back to the time of ancient Greece. Today exercise is viewed not only as a leisurely activity but also as an effective preventive and therapeutic tool in medicine. Further biomedical studies in exercise physiology and biochemistry reports that strenuous physical exercise might cause oxidative lipid damage in various tissues. The generation of reactive oxygen species is elevated to a level that overwhelms the tissue antioxidant defense systems resulting in oxidative stress.The Handbook of Oxidants and Antioxidants in Exercise examines the different aspects of exercise-induced oxidative stress, its management, and how reactive oxygen may affect the functional capacity of various vital organs and tissues. It includes key related issues such as analytical methods, environmental factors, nutrition, aging, organ function and several pathophysiological processes.This timely publication will be of relevance to those in biomedical science and was designed to be readily understood by the general scientific audience.



Protein Dimerization and Oligomerization in Biology

Author : Jacqueline M. Matthews

Publisher : Springer Science & Business Media

Page : 184 pages

File Size : 49,22 MB

Release : 2012-09-04

Category : Medical

ISBN : 1461432294

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Book Description

This volume has a strong focus on homo-oligomerization, which is surprisingly common. However, protein function is so often linked to both homo- and hetero-oligomerization and many heterologous interactions likely evolved from homologous interaction, so this volume also covers many aspects of hetero-oligomerization.



Gene Expression and Regulation

Author : Jun Ma

Publisher : Springer

Page : 0 pages

File Size : 19,81 MB

Release : 2010-12-24

Category : Science

ISBN : 9781441922038

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Book Description

This book offers a comprehensive look at the science of gene expression and regulation. Focusing on topics such as actions of nuclear receptors, RNA processing, and DNA methylation and imprinting, Gene Expression and Regulation is edited by a leading biologist and includes contributions by experts in the field. The focus is on scientific concepts and issues, rather than specific organisms or experimental approaches.



Calcium Entry Channels in Non-Excitable Cells

Author : Juliusz Ashot Kozak

Publisher : CRC Press

Page : 343 pages

File Size : 39,69 MB

Release : 2017-07-14

Category : Science

ISBN : 149875273X

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Book Description

Calcium Entry Channels in Non-Excitable Cells focuses on methods of investigating the structure and function of non-voltage gated calcium channels. Each chapter presents important discoveries in calcium entry pathways, specifically dealing with the molecular identification of store-operated calcium channels which were reviewed by earlier volumes in the Methods in Signal Transduction series. Crystallographic and pharmacological approaches to the study of calcium channels of epithelial cells are also discussed. Calcium ion is a messenger in most cell types. Whereas voltage gated calcium channels have been studied extensively, the non-voltage gated calcium entry channel genes have only been identified relatively recently. The book will fill this important niche.



Principles of Bone Biology

Author : John P. Bilezikian

Publisher : Academic Press

Page : 2074 pages

File Size : 37,11 MB

Release : 2008-09-29

Category : Medical

ISBN : 0080568750

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Book Description

Principles of Bone Biology provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. It is the essential resource for anyone involved in the study of bone biology. Bone research in recent years has generated enormous attention, mainly because of the broad public health implications of osteoporosis and related bone disorders. - Provides a "one-stop" shop. There is no need to search through many research journals or books to glean the information one wants...it is all in one source written by the experts in the field - The essential resource for anyone involved in the study of bones and bone diseases - Takes the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics - Readers can easily search and locate information quickly as it will be online with this new edition



Immunity and Inflammation in Health and Disease

Author : Shampa Chatterjee

Publisher : Academic Press

Page : 477 pages

File Size : 46,53 MB

Release : 2017-08-31

Category : Medical

ISBN : 0128054026

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Book Description

Immunity and Inflammation in Health and Disease: Emerging Roles of Nutraceuticals and Functional Foods in Immune Support provides a comprehensive description of the various pathways by which the vertebrate immune system works, the signals that trigger immune response and how fnew and novel nutraceuticals and functional foods, can be used to contain inflammation and also to boost immunity and immune health. Inflammation is a tool to fight pathogens and the vertebrate immune system has a very complex network of cells to achieve this. However inflammation that goes awry is also the leding cause of several diseases ranging from cardiovascular diseases to diabetes. This book covers the entire gamut from the various cellular players in the inflammation-immune response to its ramifications in terms of protection against pathogens as well as in onset of metabolic, aging and auto-immune related diseases. Finally, the balancing role of dietary nutrients between host defence and immune support is also showcased. The first three scetions explain the various components of the immune system and their modes of activation. The fourth section deals with the ramifications of a robust and execessive inflammatory response. The fifth section is focused on the association between nutrition and immunity and how deficiencies in certain nutrients may affect immunocompetence. The sixth section chapters represent a vision of paradigm shifts within the field and discusses possible future directions. This bool will be a valuable reference for researchers studying immune health either in academia, or in the nutraceutical or functional food industries. Product developers in nutraceutical, supplement, functional food, and health food companies will also appreciate the information presented here. - Conceptualizes the key features in natural products which can boost immune function and immune health - Explains the intricate mechanistic aspects and balance behind immune health - Presents the pathophysiology of several diseases associated with immune system disruption



Encyclopedia of Signaling Molecules

Author : Sangdun Choi

Publisher : Springer

Page : 0 pages

File Size : 39,56 MB

Release : 2012-07-09

Category : Medical

ISBN : 9781441904607

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Book Description

Biological processes are driven by complex systems of functionally interacting signaling molecules. Thus, understanding signaling molecules is essential to explain normal or pathological biological phenomena. A large body of clinical and experimental data has been accumulated over these years, albeit in fragmented state. Hence, systems biological approaches concomitant with the understanding of each molecule are ideal to delineate signaling networks/pathways involved in the biologically important processes. The control of these signaling pathways will enrich our healthier life. Currently, there are more than 30,000 genes in human genome. However, not all the proteins encoded by these genes work equally in order to maintain homeostasis. Understanding the important signaling molecules as completely as possible will significantly improve our research-based teaching and scientific capabilities. This encyclopedia presents 350 biologically important signaling molecules and the content is built on the core concepts of their functions along with early findings written by some of the world’s foremost experts. The molecules are described by recognized leaders in each molecule. The interactions of these single molecules in signal transduction networks will also be explored. This encyclopedia marks a new era in overview of current cellular signaling molecules for the specialist and the interested non-specialist alike During past years, there were multiple databases to gather this information briefly and very partially. Amidst the excitement of these findings, one of the great scientific tasks of the coming century is to bring all the useful information into a place. Such an approach is arduous but at the end will infuse the lacunas and considerably be a streamline in the understanding of vibrant signaling networks. Based on this easy-approach, we can build up more complicated biological systems.



Practical Soft Tissue Pathology: A Diagnostic Approach E-Book

Author : Jason L. Hornick

Publisher : Elsevier Health Sciences

Page : 627 pages

File Size : 22,24 MB

Release : 2017-11-14

Category : Medical

ISBN : 032355590X

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Book Description

Part of the in-depth and practical Pattern Recognition series, Practical Surgical Soft Tissue Pathology, 2nd Edition, helps you arrive at an accurate diagnosis by using a proven pattern-based approach. Leading diagnosticians guide you through the most common patterns seen in soft tissue pathology, applying appropriate immunohistochemistry and molecular testing, avoiding pitfalls, and making the best diagnosis. High-quality illustrations capture key morphologic patterns for a full range of common and rare tumor types, and a "visual index" at the beginning of the book directs you to the exact location of in-depth diagnostic guidance. - A consistent chapter organization by histologic pattern considers soft tissue tumors the way you approach them in daily practice, helping you arrive at a quick and accurate diagnosis. - A user-friendly design color-codes patterns to specific entities, and key points are summarized in tables and text boxes, so you can quickly and easily find what you are looking for. - Sweeping content updates keep you at the forefront of recent findings regarding all major neoplastic and non-neoplastic diseases of the soft tissues. - Improved pattern call-outs are now linked directly within the chapter, reinforcing the patterns for more efficient and complete understanding. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.