The Molecular Basis of Electron Transport


Book Description

The Molecular Basis of Electron Transport presents the proceedings of the Miami Winter Symposia, held in Miami, Florida, on January 13–14, 1972. This book focuses on the development of the mitochondrial electron transport system by a symbiotic relationship of some bacteria with the cell. Comprised of 15 chapters, this volume starts with an overview of the structure and function of mitochondria. This book then explains all of the major categories of mitochondrial phenomena and provides the detailed molecular mechanism for mitochondrial energy coupling. Other chapters discuss the five postulates of the electromechanochemical model, including the super molecule concept, the principle of electromechanochemical energy transduction, conformon coupling, field-induced generation of the linkage system, and the de facto unit of mitochondrial control. Finally, the reader is introduced to the liver microsomal enzyme system, which catalyzes the hydroxylation of a variety of drugs, hydrocarbons, and fatty acids. Biologists, molecular biologists, and biochemists will find this book extremely useful.







The Molecular Basis of Biological Transport


Book Description

Miami Winter Symposia, Volume 3: The Molecular Basis of Biological Transport covers the proceedings of the symposium held in Miami on January 10-11, 1972. The book discusses the life of Feodor Lynen and his lecture on carbon dioxide fixation; the biochemical significance of the anion transporting systems of mitochondria, especially that of amino acid systems; and the possible functional roles of transport through membrane junctions. The text also describes the role of chlorotetracycline as a fluorescent chelate probe for monitoring Ca++ and Mg++ binding to biological membranes; and the effects of carcinogens and steroid hormones on the structural apparatus involved in protein synthesis and export. The nature and regulation of hexose uptake by Escherichia coli; the role of bacterial phosphotransferase system in sugar transport; and energy coupling to lactose transport in Escherichia coli are also considered. The book further tackles citrate transport by Bacillus subtilis; leucine transport in Escherichia coli; and the transport mechanism in isolated bacterial cytoplasmic membrane vesicles. Biochemists, microbiologists, pharmacologists, physiologists, and people involved in enzyme and metabolic research will find the book invaluable.




The Molecular Basis of Bacterial Metabolism


Book Description

The present volume contains 17 lectures of the 41 st Mosbach Colloquium of the Gesellschaft fiir Biologische Chemie, held from April 5-7, 1990 on the topic "The Molecular Basis of Bacterial Metabolism". From the beginning it was not the intention of the organizers to present a comprehensive account, but rather to select new, exciting progress on sometimes exotic reactions of specifically bacterial, mainly anaerobic metabolism. Members of our society had contributed to this progress to an extent that greatly stimulated the scientific exchange with international colleagues during the days in Mosbach. The editors hope that this stimulation will be conveyed to the readers of the articles, which reach from the biochemistry of methanogenesis, via anaerobic radical reactions, metal biochemistry in hydrogen and nitrogen metabolism, conversions of light - and redox energy, to the regulation of metabolic adaptation, and the attempts to bioengineer novel pathways for the degradation of xenobiotica. We believe that the book represents a highly progressive field of over lapping disciplines, comprising microbiology and molecular genetics, chemistry of biomimetic interest, and biophysics, and that it gives insight into the impact modern technologies have on microbiological research today. The colloquium was generously supported by the Deutsche Forschungsgemeinschaft, the Paul-Martini-Stiftung, and the Fonds fiir Biologische Chemie. A. Trebst, G. Schafer, and D. Oesterhelt were a great help in preparing the program and we wish to thank them for their advice.




Molecular Basis of Biological Activity


Book Description

Molecular Basis of Biological Activity documents the proceedings of a symposium on the Molecular Basis of Biological Activity held in Caracas, Venezuela, July 11-17, 1971. This was the First Meeting of the Pan-American Association of Biochemical Societies (PAABS), and was organized by the Asociacion Venezolana de Bioquimica. The book begins by presenting a lecture on advances in the study of the mechanism of polysaccharide synthesis. This is followed by studies on rabbit muscle aldolase; the catalytic function of a-glycerolphosphate dehydrogenase; the functional and structural roles of metals in metalloenzymes; and enzyme adaptation in mammals. Separate chapters cover collagen biosynthesis and the mechanisms involved in its regulation; the organization of lipids in bilayers; the behavior of water-lipid interactions; the permease or transport systems in the mitochondrial membrane; and interaction between TTX and STX with isolated nerve membrane constituents. The final chapter examines the coupling of respiration via specific dehydrogenases to the transport of amino acids and many sugars.




The Molecular Basis of Cancer E-Book


Book Description

2015 BMA Medical Book Awards Highly Commended in Oncology Category!The Molecular Basis of Cancer arms you with the latest knowledge and cutting-edge advances in the battle against cancer. This thoroughly revised, comprehensive oncology reference explores the scientific basis for our current understanding of malignant transformation and the pathogenesis and treatment of this disease. A team of leading experts thoroughly explains the molecular biologic principles that underlie the diagnostic tests and therapeutic interventions now being used in clinical trials and practice. Detailed descriptions of topics from molecular abnormalities in common cancers to new approaches for cancer therapy equip you to understand and apply the complexities of ongoing research in everyday clinical application. - Effectively determine the course of malignancy and design appropriate treatment protocols by understanding the scientific underpinnings of cancer. - Visually grasp and retain difficult concepts easily thanks to a user-friendly format with abundant full-color figures. - Find critical information quickly with chapters following a logical sequence that moves from pathogenesis to therapy. - Stay current with the latest discoveries in molecular and genomic research. Sweeping revisions throughout include eight brand-new chapters on: Tumor Suppressor Genes; Inflammation and Cancer; Cancer Systems Biology: The Future; Biomarkers Assessing Risk of Cancer; Understanding and Using Information About Cancer Genomes; The Technology of Analyzing Nucleic Acids in Cancer; Molecular Abnormalities in Kidney Cancer; and Molecular Pathology. - Access the entire text and illustrations online, fully searchable, at Expert Consult.




Molecular Basis of Mitochondrial Pathology


Book Description

The field of mitochondrial diseases is currently one of the rapidly growing fields of research in cell and molecular biology. This volume encompasses the latest development in this field of research. The chapters cover topics in a wide range of disciplines including biophysics, biochemistry, cell and molecular biology, molecular genetics, and clinical medicine. - Summarizes growing evidence of the role of mitochondria in a large number of pathological conditions - Brings together different approaches toward understanding mitochondria diseases - Molecular and cellular biology - Clinical physiology and medicine - Details the crucial role this organelle plays in genetic regulation of various biological functions




Molecular Basis of Aging


Book Description

Using a new, integrative approach, Molecular Basis of Aging describes the aging phenomenon within mammalian organisms from the perspective of changes in information storage and coordination between hierarchical orders of structure. This unique approach provides the reader with a thorough insight into the evolution of molecular, cellular, tissue, and organ systems and processes in mammals. This informative volume contains up-to-date reviews of:







The Molecular Basis of Genetic Disorders Associated with Essential Elements Metabolism


Book Description

This pioneering book offers a distinctive exploration of a previously uncharted realm; the book effectively amalgamates the fields of biochemistry, molecular biology, and molecular genetics concerning essential element-related genetic disorders, employing a coherent and logical approach. The result is a comprehensive guide to essential metals metabolism, covering their regulation, functions, and corresponding genetic disorders. It serves as an authoritative guide for a diverse audience, including medical students, medical nutritionists, medical geneticists, and basic medical scientists. This innovative perspective is particularly pertinent in an age where interdisciplinary collaboration is essential for comprehensive patient care and medical practice. By fostering a practice-centred approach in clinical medicine, the book will inspire clinicians to embrace a holistic viewpoint. Simultaneously, it beckons basic medical scientists to delve into the enigmatic domain of genetic disorders associated with essential elements.