Designing Nanostructures at the Interface between Biomedical and Physical Systems


Book Description

Last November, the National Academies Keck Futures Initiative held the Designing Nanostructures at the Interface Between Biomedical and Physical Systems conference at which researchers from science, engineering and medicine discussed recent developments in nanotechnology, directions for future research, and possible biomedical applications. The centerpiece of the conference was breakout sessions in which ten focus groups of researchers from different fields spent eight hours developing research plans to solve various problems in the field of nanotechnology. Among the challenges were: Building a nanosystem that can isolate, sequence and identify RNA or DNA Developing a system to detect disease in vivo Sequencing a single molecule of protein Creating a biological system that will create a local hydrogen fuel source, and Growing a biological in vivo power source. Representatives from public and private funding organizations, government, industry, and the science media also participated in the focus groups. This book provides a summary of the conference focus groups. For more information about the conference, visit Keck Futures Initiative. The National Academies Keck Futures Initiative was launched in 2003 to stimulate new modes of scientific inquiry and break down the conceptual and institutional barriers to interdisciplinary research. The National Academies and the W.M. Keck Foundation believe considerable scientific progress and social benefit will be achieved by providing a counterbalance to the tendency to isolate research within academic fields. The Futures Initiative is designed to enable researchers from different disciplines to focus on new questions upon which they can base entirely new research, and to encourage better communication between scientists as well as between the scientific community and the public. Funded by a $40 million grant from the W.M. Keck Foundation, the National Academies Keck Futures Initiative is a 15-year effort to catalyze interdisciplinary inquiry and to enhance communication among researchers, funding agencies, universities, and the general publicâ€"with the object of stimulating interdisciplinary research at the most exciting frontiers. The Futures Initiative builds on three pillars of vital and sustained research: interdisciplinary encounters that counterbalance specialization and isolation; the identification and exploration of new research topics; and communication that bridges languages, cultures, habits of thought, and institutions. Toward these goals, the National Academies Keck Futures Initiative incorporates three core activities each year: Futures conferences, Futures grants, and National Academies Communication Awards.







Collaborations of Consequence


Book Description

This publication represents the culmination of the National Academies Keck Futures Initiative (NAKFI), a program of the National Academy of Sciences, the National Academy of Engineering, and the National Academy of Medicine supported by a 15-year, $40 million grant from the W. M. Keck Foundation to advance the future of science through interdisciplinary research. From 2003 to 2017, more than 2,000 researchers and other professionals across disciplines and sectors attended an annual "think-tank" style conference to contemplate real-world challenges. Seed grants awarded to conference participants enabled further pursuit of bold, new research and ideas generated at the conference.




Complex Systems


Book Description

The National Academies Keck Futures Initiative was launched in 2003 to stimulate new modes of scientific inquiry and break down the conceptual and institutional barriers to interdisciplinary research. At the Conference on Complex Systems, participants were divided into twelve interdisciplinary working groups. The groups spent nine hours over two days exploring diverse challenges at the interface of science, engineering, and medicine. The groups included researchers from science, engineering, and medicine, as well as representatives from private and public funding agencies, universities, businesses, journals, and the science media. The groups needed to address the challenge of communicating and working together from a diversity of expertise and perspectives as they attempted to solve complicated, interdisciplinary problems in a relatively short time. The summaries contained in this volume describe the problem and outline the approach taken, including what research needs to be done to understand the fundamental science behind the challenge, the proposed plan for engineering the application, the reasoning that went into it and the benefits to society of the problem solution.




The Informed Brain in a Digital World


Book Description

Digital media provide humans with more access to information than ever before-a computer, tablet, or smartphone can all be used to access data online and users frequently have more than one device. However, as humans continue to venture into the digital frontier, it remains to be known whether access to seemingly unlimited information is actually helping us learn and solve complex problems, or ultimately creating more difficulty and confusion for individuals and societies by offering content overload that is not always meaningful. Throughout history, technology has changed the way humans interact with the world. Improvements in tools, language, industrial machines, and now digital information technology have shaped our minds and societies. There has always been access to more information than humans can handle, but the difference now lies in the ubiquity of the Internet and digital technology, and the incredible speed with which anyone with a computer can access and participate in seemingly infinite information exchange. Humans now live in a world where mobile digital technology is everywhere, from the classroom and the doctor's office to public transportation and even the dinner table. This paradigm shift in technology comes with tremendous benefits and risks. Interdisciplinary Research (IDR) Teams at the 2012 National Academies Keck Futures Initiative Conference on The Informed Brain in the Digital World explored common rewards and dangers to Humans among various fields that are being greatly impacted by the Internet and the rapid evolution of digital technology. Keynote speaker Clifford Nass of Stanford University opened the dialogue by offering insight into what we already know about how the "information overload" of the digital world may be affecting our brains. Nass presented the idea of the "media budget," which states that when a new media emerges, it takes time away from other media in a daily time budget. When additional media appear and there is no time left in a person's daily media budget, people begin to "double book" media time. Personal computers, tablets, and smartphones make it easy to use several media simultaneously, and according to Nass, this double-booking of media can result in chronic multitasking, which effects how people store and manage memory. Although current fast-paced work and learning environments often encourage multitasking, research shows that such multitasking is inefficient, decreases productivity, and may hinder cognitive function. National Academies Keck Future Initiative: The Informed Brain in a Digital World summarizes the happenings of this conference.




Research at the Intersection of the Physical and Life Sciences


Book Description

Traditionally, the natural sciences have been divided into two branches: the biological sciences and the physical sciences. Today, an increasing number of scientists are addressing problems lying at the intersection of the two. These problems are most often biological in nature, but examining them through the lens of the physical sciences can yield exciting results and opportunities. For example, one area producing effective cross-discipline research opportunities centers on the dynamics of systems. Equilibrium, multistability, and stochastic behavior-concepts familiar to physicists and chemists-are now being used to tackle issues associated with living systems such as adaptation, feedback, and emergent behavior. Research at the Intersection of the Physical and Life Sciences discusses how some of the most important scientific and societal challenges can be addressed, at least in part, by collaborative research that lies at the intersection of traditional disciplines, including biology, chemistry, and physics. This book describes how some of the mysteries of the biological world are being addressed using tools and techniques developed in the physical sciences, and identifies five areas of potentially transformative research. Work in these areas would have significant impact in both research and society at large by expanding our understanding of the physical world and by revealing new opportunities for advancing public health, technology, and stewardship of the environment. This book recommends several ways to accelerate such cross-discipline research. Many of these recommendations are directed toward those administering the faculties and resources of our great research institutions-and the stewards of our research funders, making this book an excellent resource for academic and research institutions, scientists, universities, and federal and private funding agencies.




Seeing the Future with Imaging Science


Book Description

Imaging science has the power to illuminate regions as remote as distant galaxies, and as close to home as our own bodies. Many of the disciplines that can benefit from imaging share common technical problems, yet researchers often develop ad hoc methods for solving individual tasks without building broader frameworks that could address many scientific problems. At the 2010 National Academies Keck Futures Initiative Conference on Imaging Science, researchers from academia, industry, and government formed 14 interdisciplinary teams created to find a common language and structure for developing new technologies, processing and recovering images, mining imaging data, and visualizing it effectively. The teams spent nine hours over two days exploring diverse challenges at the interface of science, engineering, and medicine. NAKFI Seeing the Future with Imaging Science contains the summaries written by each team. These summaries describe the problem and outline the approach taken, including what research needs to be done to understand the fundamental science behind the challenge, the proposed plan for engineering the application, the reasoning that went into it, and the benefits to society of the problem solution.




Synthetic Biology


Book Description

Synthetic biology is an innovative and growing field that unites engineering and biology. It builds on the powerful research that came about as a result of a recombinant DNA technology and genome sequencing. By definition, synthetic biology is an interdisciplinary enterprise comprising biologists of many specialties, engineers, physicists, computer scientists and others. It promises a fundamentally deeper understanding of how living systems work and the capacity to recreate them for medicine, public health and the environment, including renewable energy. NAKFI Synthetic Biology: Building a Nation's Inspiration discusses new foundational technologies and tools required to make biology easier to engineer, considers ethical issues unique to synthetic biology, explores how synthetic biology can lead to an understanding of the principles underlying natural genetic circuits and debates how synthetic biology can be used to answer fundamental biological questions.




The Future of Human Healthspan


Book Description

An individual's healthspan can be defined as the length of time an individual is able to maintain good health. In 2007, over one hundred experts and researchers from public and private institutions across the nation convened to find new ways of addressing the human healthspan and the elusive nature of aging. Experts in public health, bioengineering, neuroscience and gerontology discussed how stress and lifestyle influence the decline of health at older ages. Other discussions focused on the integration of technology in the quality of life, gerontology, regenerative medicine and life expectancy with regard to social and behavioral traits. Still, other groups explored topics such as the cellular and molecular mechanisms of biological aging, the effects of exercise on the human healthspan, and changes in social context to enhance functional status of the elderly. Most importantly, experts agreed that it was imperative to ensure that the elderly have access to medical services by establishing relationships with health care and insurance providers.




Ecosystem Services


Book Description

Natural environments provide enormously valuable, but largely unappreciated, services that aid humans and other earthlings. It is becoming clear that these life-support systems are faltering and failing worldwide due to human actions that disrupt nature's ability to do its beneficial work. Ecosystem Services: Charting a Path to Sustainability documents the National Academies' Keck Futures Initiative Conference on Ecosystem Services. At this conference, participants were divided into 14 interdisciplinary research teams to explore diverse challenges at the interface of science, engineering, and medicine. The teams needed to address the challenge of communicating and working together from a diversity of expertise and perspectives as they attempted to solve a complicated, interdisciplinary problem in a relatively short time. Ecosystem Services: Charting a Path to Sustainability describes how ecosystem services scientists work to document the direct and indirect links between humanity's well-being and the many benefits provided by the natural systems we occupy. This report explains the specific topics the interdisciplinary research teams addressed at the conference, including the following: -how ecosystem services affect infectious and chronic diseases -how to identify what resources can be produced renewably or recovered by developing intense technologies that can be applied on a massive scale -how to develop social and technical capabilities to respond to abrupt changes in ecosystem services -how to design agricultural and aquacultural systems that provide food security while maintaining the full set of ecosystem services needed from landscapes and seascapes -how to design production systems for ecosystem services that improve human outcomes related to food and nutrition -how to develop appropriate methods to accurately value natural capital and ecosystem services -how to design a federal policy to maintain or improve natural capital and ecosystem services within the United States, including measuring and documenting the effectiveness of the policy -how to design a system for international trade that accounts for impacts on ecosystem services -how to develop a program that increases the American public's appreciation of the basic principles of ecosystem services