The Natural History of Cancer


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Excerpt from The Natural History of Cancer: With Special Reference to Its Causation and Prevention The subject of cancer has hitherto been investigated far too exclusively by the pursuit of details in ultimate analysis and hardly at all by the synthetical and comparative methods, which have been so profitably employed in other branches of biological research. As that fine pathologist Billroth has remarked Everything is too hurried nowadays. -we suffer from an insatiable craving for new - or apparently new - facts, in the hope of obtaining a possible sensational success. N 0 time is allowed to reflect upon, or to reconsider, the onward course of scientific inquiry. Where are we What have we left behind What is ahead Is it worth while to go farther in this direction or in that? Has detailed work given us a profitable knowledge of, or an insight into, the whole subject? No one finds time to answer such questions. In order that the immense stores of miscellaneous items of knowledge accumulated during the last half-century by dispersive analysis, may be profitably utilized for cancer research, concentration is above all things necessary for only thus can a higher plane of progress be attained. Moreover, since the cure of cancer altogether transcends present experience, I have in this work specially endeavoured to elucidate the causation and prevention of the disease rather than its cure for which, in my opinion, reliable indications are lacking. To this end I have devised and applied a new method of cancer research - Which may be called synthetic - whereby I have shown that there are modes of life, various habits and so forth, which tend to prevent the incidence of cancer almost entirely in healthy stocks, and greatly to reduce its ravages, even among those hereditarily predisposed. Such are the objects to which the present work is dedicated. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works.




NATURAL HISTORY OF CANCER


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NATURAL HIST OF CANCER W/SPECI


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This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.




The Natural History of Cancer, with Special Reference to Its Causation and Prevention


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This historic book may have numerous typos and missing text. Purchasers can usually download a free scanned copy of the original book (without typos) from the publisher. Not indexed. Not illustrated. 1908 edition. Excerpt: ...as Saccharomyces neoformans. In most cases, the tumours thus produced were nothing but inflammatory pseudo-plasms. But, with cultures of a microbe of this kind, isolated from a fermenting infusion of lemon-skin, he claims to have produced, by inoculation, malignant epithelial neoplasms (cancers) in dogs. When these cultures were injected into the peritoneal cavity, nodular formations at first resulted; from these fresh cultures were made, and after the microbe had thus been passed through several dogs, it was found to have acquired increased virulence. Of thirty dogs inoculated with cultures thus produced, in two Sanfelice claims to have caused true epithelial cancer. In the case of a bitch inoculated in the posterior mammary region, there was considerable tumefaction at the seat of inoculation one month afterwards. The animal then became cachectic, and died ten months after inoculation. Besides the mammary tumour, post-mortem examination revealed enlargements of the adjacent inguinal and abdominal lymph-glands. Histologically examined, all of these tumours showed 1 British Medical Journal, 1892, vol. ii., p. 1356. 1 Cent. f. Bakt., etc., 1895, Bd. xvii., S. 113 and 625; Bd. xviii., S. 521; Bd. xxiii., SS. 155 and 276; and Bd. xxi., 1902, S. 254. Also series of articles in Zeits. f. Hygiene und Inleclions-krankheiten, 1895, Bd. xxi., SS. 32 and 394; Bd. xxii., 1896, S. 171; Bd. xxvi., S. 298; Bd. xxix., 1898, S. 463. the structure of glandular cancer. Numerous "parasites " were present in them, but no cultures could be obtained. The latter defect is unfortunate, as the possibility of the animal having been previously affected with mammary cancer, to which bitches are exceedingly prone, thus cannot be excluded. A similar defect...




The Natural History of Cancer, with Special Reference to Its Causation and Prevention, - Primary Source Edition


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This is a reproduction of a book published before 1923. This book may have occasional imperfections such as missing or blurred pages, poor pictures, errant marks, etc. that were either part of the original artifact, or were introduced by the scanning process. We believe this work is culturally important, and despite the imperfections, have elected to bring it back into print as part of our continuing commitment to the preservation of printed works worldwide. We appreciate your understanding of the imperfections in the preservation process, and hope you enjoy this valuable book.




UICC Manual of Clinical Oncology


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The Manual of Clinical Oncology, Ninth Edition, published with the International Union Against Cancer (UICC), provides a concise, accessible and feasible reference covering state of art multidisciplinary clinical oncology in order to meet the needs of clinicians caring for cancer patients throughout the world. Edited by world-renowned practising oncologists and written by key opinion leaders, this book contains authoritative and up-to-date information on cancer detection, diagnosis and treatment alongside topics such as survivorship, special populations and palliative care. Remodelled and revised for the ninth edition to provide practical information to oncology workers, the UICC Manual of Clinical Oncology is structured in two parts. Part 1 covers general principles of cancer diagnosis and management with additional attention to special settings in oncology, including supportive care and survivorship, and Part 2 covers site-specific multidisciplinary cancer management. The edition includes up-to-date summaries of all treatment modalities (medical, surgical and radiation) for all tumour sites. It also contains the latest TNM classifications outlined in the TNM Classification of Malignant Tumours. The ninth edition includes: Practical presentation with bullet points, tables, and flow charts intended to facilitate quick reference for day-to-day clinical practice in busy oncology environments, Representation of multidisciplinary care for site specific management, Evidence-based approaches to management, including specific treatment recommendations and investigations guided by clinical practice guidelines, State of art evidence-based recommendations that take into consideration the lack of availability of certain medications or resources, as well as practice variations, in different and remote regions of the world, and Contemporary topics on cancer treatment, such as cancer informatics, evidence levels, principles of prognostication, survivorship and cancer in pregnancy. Oncologists, oncologists-in-training, nurses working with cancer patients and other health professionals responsible for treating and caring for those with cancers will find the UICC Manual of Clinical Oncology an indispensable and comprehensive resource.




How Tobacco Smoke Causes Disease


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This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.




Concepts of Epidemiology


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First edition published in 2002. Second edition published in 2008.




Cancer as a Metabolic Disease


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The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention. It expands upon Otto Warburg's well-known theory that all cancer is a disease of energy metabolism. However, Warburg did not link his theory to the "hallmarks of cancer" and thus his theory was discredited. This book aims to provide evidence, through case studies, that cancer is primarily a metabolic disease requring metabolic solutions for its management and prevention. Support for this position is derived from critical assessment of current cancer theories. Brain cancer case studies are presented as a proof of principle for metabolic solutions to disease management, but similarities are drawn to other types of cancer, including breast and colon, due to the same cellular mutations that they demonstrate.