› › The Recent Topics In Genetic Polymorphisms

The Recent Topics in Genetic Polymorphisms

Author : Mahmut Çalışkan

Publisher : BoD – Books on Demand

Page : 149 pages

File Size : 29,60 MB

Release : 2020-05-13

Category : Medical

ISBN : 1789858917

Get eBook

Book Description

The book in your hands presents chapters revealing the magnitude of genetic polymorphisms that exist in different kinds of living beings. Natural populations contain a considerable amount of genetic change, which provides a genomic flexibility that can be used as a raw material for adaptation to changing environmental conditions. The analysis of genetic polymorphisms provides information about DNA sequence changes at a given locus. The increasing availability of PCR-based molecular markers allows for the detailed analyses and the detection of genetic changes influencing some important traits. The purpose of this book is to provide a glimpse into the dynamic process of genetic polymorphisms by presenting the thoughts of scientists engaged in the generation of new ideas and techniques employed for the assessment of genetic polymorphisms. The book should prove useful to students, researchers and experts in the area of molecular genetics.



Genetic Polymorphisms

Author : Mahmut Çalışkan

Publisher : BoD – Books on Demand

Page : 226 pages

File Size : 43,88 MB

Release : 2022-05-04

Category : Medical

ISBN : 1839688106

Get eBook

Book Description

This book provides a glimpse into the dynamic process of genetic polymorphism by presenting studies carried out on different kinds of organisms at the DNA level or gene expression level. Chapters address such topics as genetic polymorphism in animals, gametocyte biomarkers, thrombotic disorders, prostate cancer, and more.



Genetic Polymorphisms

Author : Narasimha Reddy Parine

Publisher : BoD – Books on Demand

Page : 282 pages

File Size : 11,33 MB

Release : 2017-09-06

Category : Medical

ISBN : 9535135155

Get eBook

Book Description

The objective of this Genetic Polymorphisms book is to rehighlight and provide few updates on the role of genetic polymorphisms in medicine and agriculture, which void emerging opinion on "full death" of genetic polymorphisms as useful genetic markers. Chapters presented here demonstrate the future benefit of SNPs in many genetic studies as well as prognosis disease and diagnosis.



Genetic Polymorphism and cancer susceptibility

Author : Aga Syed Sameer

Publisher : Springer Nature

Page : 353 pages

File Size : 38,91 MB

Release : 2021-04-22

Category : Medical

ISBN : 9813366990

Get eBook

Book Description

This book discusses the role of genetic polymorphism in susceptibility to cancers. The book explores the understanding of differences between the genetic polymorphisms and mutations.It reviews the mechanisms underlying the effect of polymorphism in genes encoding proteins that play an essential role in metabolism, signal transduction, cell cycle, and DNA repair mechanisms. Further, it investigates various techniques that are used for analyzing the genetic polymorphisms. The book contains many chapters which summarize the importance of genetic information obtained from polymorphism-based pharmaco-genetic tests to predict better drug response and life-threatening adverse reactions to chemotherapeutic agents, help in understanding of the impact of SNPs on gene function, and gives overview of the different SNP databases for examination. This book, therefore, serves as an essential guidebook for independent researchers as well as institutions working in this specialised field.



Genetic Polymorphism and Disease

Author : Syed Sameer Aga

Publisher : CRC Press

Page : 1256 pages

File Size : 38,32 MB

Release : 2022-12-06

Category : Science

ISBN : 1000688216

Get eBook

Book Description

Genetic polymorphisms are important determinants of phenotypic variations and may modulate the risk to or even cause various diseases including genetic disorders and multifactorial diseases. Genetic polymorphisms also serve as important genetic, population and evolutionary markers that allow the study of genetic and evolutionary aspects of individuals, populations and organisms and aid in tracing the evolutionary and parental lineages. Genetic polymorphisms in low penetrance genes are responsible for the alterations in the gene expression of critical signal transduction proteins and metabolic enzymes. Some of these polymorphisms are linked to increased susceptibility to various diseases especially cancers, cardiovascular diseases, immune disorders, neurological pathologies. This book collates the reviews on the roles played by polymorphisms in critical metabolic, signal transduction, cell cycle or DNA repair genes either directly or indirectly in the disease mechanisms. The focus is on various techniques for identifying the various Single Nucleotide Polymorphisms (SNPs). Polymorphism studies document the affect SNPs, and their expressions have upon the functionality of the enzymes, proteins. Key Features Describes the genetic polymorphism and its various types Discusses the role of genetic polymorphisms in modulating the risk of various human diseases Explores various molecular techniques used for detecting GPs Characterizes the role of SNPs in modulating the susceptibility of human diseases Provides a genetic basis for individual variations in response to therapeutics



Genetic Polymorphisms: An Integrated Approach

Author : Vince Clinton

Publisher : Murphy & Moore Publishing

Page : 244 pages

File Size : 24,80 MB

Release : 2021-11-16

Category : Science

ISBN : 9781639872541

Get eBook

Book Description

The simultaneous occurrence of two or more discontinuous alleles or genotypes in a population is termed as genetic polymorphism. Most genetic polymorphisms are silent and do not interfere with the expression or function of a gene. Polymorphisms are classified into single nucleotide polymorphisms, small scale insertions and deletions, polymorphic repetitive elements, and microsatellites. The single nucleoid changes which happen in the genome in a particular location are termed as single nucleoid polymorphisms (SNPs). They are associated with both coding and non-coding regions. In humans, more than 100 million SNPs have been recognised. This book covers in detail some existent theories and innovative concepts revolving around genetic polymorphisms. It includes some of the vital pieces of work being conducted across the world, on various topics related to genetic polymorphism. Those in search of information to further their knowledge will be greatly assisted by this book.



Genetic Polymorphisms and Susceptibility to Disease

Author : Mark Steven Miller

Publisher : CRC Press

Page : 298 pages

File Size : 24,34 MB

Release : 2000-04-27

Category : Science

ISBN : 9780748408221

Get eBook

Book Description

Genetic Polymorphisms and Susceptibity to Disease provides a reference for established researchers in genetic research. The book provides a broad but thorough overview of how allelic gene differences influence disease susceptibility in the human population, and will be a useful reference to researchers across a range of disciplines, for example, oncology, cardiology and immunology . In addition, this book serves as a primer for students first entering the field of genetic research.



Single Nucleotide Polymorphisms

Author : Pui-Yan Kwok

Publisher : Springer Science & Business Media

Page : 276 pages

File Size : 30,79 MB

Release : 2008-02-04

Category : Medical

ISBN : 1592593275

Get eBook

Book Description

A comprehensive collection of readily reproducible techniques for the difficult process of single nucleotide polymorphisms (SNP) discovery and genotyping. These cutting-edge protocols for mutation/SNP detection utilize denaturing high-performance liquid chromatography (dHPLC), single-strand conformation polymorphism (SSCP), conformation-sensitive gel electrophoresis (CSGE), chemical cleavage, and direct sequencing. Equally powerful and up-to-date methods are given for genotyping SNPs, including molecular beacons, the Taqman assay, single-base extension approaches, pyrosequencing, ligation, the Invader assay, and primer extension with mass spectrometry detection.



Genetic Diversity and Disease Susceptibility

Author : Yamin Liu

Publisher : BoD – Books on Demand

Page : 166 pages

File Size : 13,26 MB

Release : 2018-10-17

Category : Medical

ISBN : 1789842018

Get eBook

Book Description

Polymorphism or variation in DNA sequence can affect individual phenotypes such as color of skin or eyes, susceptibility to diseases, and response to drugs, vaccines, chemicals, and pathogens. Especially, the interfaces between genetics, disease susceptibility, and pharmacogenomics have recently been the subject of intense research activity. This book is a self-contained collection of valuable scholarly papers related to genetic diversity and disease susceptibility, pharmacogenomics, ongoing advances in technology, and analytic methods in this field. The book contains nine chapters that cover the three main topics of genetic polymorphism, genetic diversity, and disease susceptibility and pharmacogenomics. Hence, this book is particularly useful to academics, scientists, physicians, pharmacists, practicing researchers, and postgraduate students whose work relates to genetic polymorphisms.



Single Nucleotide Polymorphisms

Author : Anton A. Komar

Publisher : Humana Press

Page : 464 pages

File Size : 30,58 MB

Release : 2012-02-25

Category : Medical

ISBN : 9781617796791

Get eBook

Book Description

In recent years, single nucleotide polymorphisms have received increased and special attention in a rapidly developing field of personalized medicine and drug treatment. Comprising more than eighty percent of all known polymorphisms, single nucleotide polymorphisms (SNPs) are primarily responsible for phenotypic differences between individuals, and have been suggested to affect the development of diseases in humans and the response to drug treatment and environmental stress. In Single Nucleotide Polymorphisms: Methods and Protocols, Second Edition, expert researchers explore the latest advances in this area, highlighting the substantial progress that has been made in SNP genotyping, examining recent developments in high-throughput genotyping approaches, and exploring our new understanding of the impact of SNPs on gene function. Chapters address the impact of SNPs on phenotype, examine SNP databases, look at methods that have been applied for SNP bioinformatics discovery and analysis, and discuss advanced experimental approaches used for SNP detection. Composed in the highly successful Methods in Molecular BiologyTM series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls. Current and innovative, Single Nucleotide Polymorphisms: Methods and Protocols, Second Edition is an essential guidebook for individual researchers as well as institutions and companies working in the field.