The Richard and Hinda Rosenthal Lecture 2007


Book Description

In 1988, a new outreach program was launched at the Institute of Medicine. Through the generosity of the Richard and Hinda Rosenthal Foundation, a lecture series was established to bring to greater attention some of the critical health policy issues facing our nation today. Each year one or more experts present their views and insights on a major health topic, and the Institute of Medicine later publishes these lectures for the benefit of a wider audience. The Rosenthal Lectures have attracted an enthusiastic following among health policy researchers and decision makers in Washington, D.C., and across the country. The lectures typically engender a lively and productive dialogue. In this volume, we are proud to present the remarks of the 2007 Rosenthal Lecturers-Drs. Kevin Grumbach, Fitzhugh Mullan, and Marla E. Salmon-who spoke on "Transforming Today's Health Workforce to Meet Tomorrow's Demands."




The Richard and Hinda Rosenthal Lecture 2008


Book Description

The 2008 Rosenthal Lecture featured a talk on Prospects for Health Reform in 2009 and Beyond. The distinguished speaker was Julie Rovner, National Public Radio correspondent and health expert, with introduction by Harvey V. Fineberg, MD, PhD.




Vegetables, Whole Grains, and Their Derivatives in Cancer Prevention


Book Description

Vegetables, Whole Grains and their Derivatives in Cancer Prevention looks in detail at the evidence regarding the effects and mechanisms of action of potentially cancer-preventive components and their sources from plant kingdom. The book covers current knowledge on certain foods and their constituents in cancer prevention, such as cruciferous and green leafy vegetables, nuts and seeds, whole grains, tomato lycopene and carotenoids, alliums and their sulphur and selenium constituents, and capsaicinoids from chilli peppers. It focuses not only on single compounds but aims to widen the view by discussing a whole-diet approach in cancer prevention. A single component may lose its chemopreventive efficacy when isolated from the food matrix and in many cases isolated and concentrated components as supplements may actually induce tumor development. Apart from describing the effects and mechanisms of action, the chapters also contain information on intake, bioavailability, metabolism and possible toxic effects of foods and components presented. Evaluation and comparison of the data from mechanistic studies in vitro with those from animal experiments in vivo form a basis for applying the current knowledge to human nutrition in the field of carcinogenesis. With contributions from leading experts in the field, this book is an invaluable resource for scientists and professionals working in cancer research, as well as individuals involved in food and nutrition.




Clinical Uro-Andrology


Book Description

In this volume, undisputed leading experts from Europe and beyond come together to cover the field of andrology in its entirety, providing a guide that will be of value to urologists and other physicians in their daily clinical practice. It is designed for a wide audience, including both those coming into contact with andrological issues for the first time and more experienced readers requiring updated guidelines and advice on the most controversial and thorny issues. A wide range of topics is covered, including male genital abnormalities, disorders of pubertal development, gender identity disorders, Peyronie’s disease, sexual dysfunction, hypogonadism and infertility, urogenital infections, urogenital cancers, and andrological emergencies. Clinical Andrology will prove an invaluable quick consulting tool, rigorous in its scientific content but at the same time easy to read and rich in images and tables.




Age-Related Macular Degeneration, Third Edition


Book Description

The value of Age-Related Macular Degeneration has stood the test of time, but progress in both basic and clinical ophthalmology has been relentless, mandating the need for an updated book. This second edition focuses on the pathophysiology and the epidemiology of age-related macular degeneration (AMD), the clinical features and management of dry an




Perez and Brady's Principles and Practice of Radiation Oncology


Book Description

The thoroughly updated fifth edition of this landmark work has been extensively revised to better represent the rapidly changing field of radiation oncology and to provide an understanding of the many aspects of radiation oncology. This edition places greater emphasis on use of radiation treatment in palliative and supportive care as well as therapy.




A Practical Guide to Designing Phase II Trials in Oncology


Book Description

How to identify optimal phase II trial designs Providing a practical guide containing the information needed to make crucial decisions regarding phase II trial designs, A Practical Guide to Designing Phase II Trials in Oncology sets forth specific points for consideration between the statistician and clinician when designing a phase II trial, including issues such as how the treatment works, choice of outcome measure and randomization, and considering both academic and industry perspectives. A comprehensive and systematic library of available phase II trial designs is included, saving time otherwise spent considering multiple manuscripts, and real-life practical examples of using this approach to design phase II trials in cancer are given. A Practical Guide to Designing Phase II Trials in Oncology: Offers a structured and practical approach to phase II trial design Considers trial design from both an academic and industry perspective Includes a structured library of available phase II trial designs Is relevant to both clinical and statistical researchers at all levels Includes real life examples of applying this approach For those new to trial design, A Practical Guide to Designing Phase II Trials in Oncology will be a unique and practical learning tool, providing an introduction to the concepts behind informed decision making in phase II trials. For more experienced practitioners, the book will offer an overview of new, less familiar approaches to phase II trial design, providing alternative options to those which they may have previously used.




Encyclopedia of Health Services Research


Book Description

Today, as never before, healthcare has the ability to enhance the quality and duration of life. At the same time, healthcare has become so costly that it can easily bankrupt governments and impoverish individuals and families. Health services research is a highly multidisciplinary field, including such areas as health administration, health economics, medical sociology, medicine, , political science, public health, and public policy. The Encyclopedia of Health Services Research is the first single reference source to capture the diversity and complexity of the field. With more than 400 entries, these two volumes investigate the relationship between the factors of cost, quality, and access to healthcare and their impact upon medical outcomes such as death, disability, disease, discomfort, and dissatisfaction with care. Key Features Examines the growing healthcare crisis facing the United States Encompasses the structure, process, and outcomes of healthcare Aims to improve the equity, efficiency, effectiveness, and safety of healthcare by influencing and developing public policies Describes healthcare systems and issues from around the globe Key Themes Access to Care Accreditation, Associations, Foundations, and Research Organizations Biographies of Current and Past Leaders Cost of Care, Economics, Finance, and Payment Mechanisms Disease, Disability, Health, and Health Behavior Government and International Healthcare Organizations Health Insurance Health Professionals and Healthcare Organizations Health Services Research Laws, Regulations, and Ethics Measurement; Data Sources and Coding; and Research Methods Outcomes of Care Policy Issues, Healthcare Reform, and International Comparisons Public Health Quality and Safety of Care Special and Vulnerable Groups The Encyclopedia is designed to be an introduction to the various topics of health services research for an audience including undergraduate students, graduate students, andgeneral readers seeking non-technical descriptions of the field and its practices. It is also useful for healthcare practitioners wishing to stay abreast of the changes and updates in the field.




Testicular Cancer


Book Description

"Testicular Cancer" explores the various forms of the disease, discusses its detection, diagnosis, and treatment, and gives an overview of current clinical and laboratory research. This relatively rare form of cancer is seen most often in young men in their late teens, 20s, and 30s. The disease, which once killed most patients, now has a survival rate greater than 90 percent, making it one of the success stories in the history of cancer treatment. Important historical research breakthroughs in the fight against testicular cancer are highlighted, as well as important questions and challenges facing scientists in the future.




Environmental Carcinogenesis


Book Description

Environmental Carcinogenesis, Volume 96 in the Advances in Pharmacology series, reports on work done with carcinogenic metals and the mechanisms of their carcinogenicity, including Arsenic and Chromate. Chapters in this release include Breast cancer carcinogenesis by organophosphate pesticides, Polyadenylation of Canonical histone H3.1 in Carcinogenesis, Epigenomic reprogramming in iAs-mediated carcinogenesis, MicroRNAs and epigenetic regulation in metal-induced angiogenesis and carcinogenesis, Environmental epigenetics and new mechanistic markers of chemical exposure, Arsenic carcinogenesis by inhibition of DNA repair, Genetic and environmental reprogramming of the sarcoma epigenome, Mechanism of chromate carcinogenesis by chromatin alterations, and more. Other chapters cover Arsenic carcinogenesis and microRNAs, Epigenetic mechanism of Cr(VI)-induced cell malignant transformation and tumorigenesis, The dark side of NRF2 in arsenic carcinogenesis, and Chemical mechanisms of DNA damage by carcinogenic chromium(VI). - Covers metal carcinogens - Includes discussions on the mechanisms of cancer formation - Provides updates on the diverse mechanisms that drive cancer formation by metals