The Porphyrin Handbook, Volume 5


Book Description

Scientists in such fields as mathematics, physics, chemistry, biochemistry, biology, and medicine are currently involved in investigations of porphyrins and their numerous analogues and derivatives. Porphyrins are being used as platforms for the study of theoretical principles, as catalysts, as drugs, as electronic devices, and as spectroscopic probes in biology and medicine. The need for an up-to-date and authoritative treatise on the porphyrin system has met with universal acclaim amongst scientists and investigators.




The Porphyrin Handbook


Book Description

The Porphyrin Handbook, Volume 17: Phthalocyanines: Properties and Materials provides information pertinent to every aspect of the chemistry, synthesis, spectroscopy, and structure of phthalocyanines. This book examines the biology and medical implications of porphyrin systems. Organized into five chapters, this volume begins with an overview of the effects of pressure, temperature, electromagnetic radiation, and particle impact on phthalocyanines. This text then examines. Other chapters consider the research on phthalocyanine thin films, with emphasis on studies that are concerned primarily with film structures. This book discusses as well the nature of the phthalocyanine aggregation process, how an aggregate is defined, and the issues of its bonding and structure. The final chapter deals with the advances in the design of composites of phthalocyanines or porphyrins and inorganic hosts and some of the most significant finding in the catalysis with these systems. This book is a valuable resource for research scientists, engineers, and clinicians.




The Porphyrins V4


Book Description

The Porphyrins, Volume IV: Physical Chemistry, Part B focuses on the physical chemistry of porphyrins, their precursors, catabolic derivatives, and related compounds. The book covers nuclear magnetic resonance (NMR) spectroscopy of diamagnetic and paramagnetic porphyrins and electron nuclear double resonance (ENDOR) spectroscopy of chlorophylls and related systems. It also encompasses electron spin resonance (ESR) spectroscopy of porphyrin pi cations and anions, porphyrin excited states, metalloporphyrins, hemoproteins, and hemes. This volume is organized into nine chapters and begins with an overview of NMR theory and the use of NMR spectroscopy to study diamagnetic porphyrins and paramagnetic metalloporphyrins. The discussion then shifts to the theory of ENDOR spectroscopy and the application of ENDOR spectroscopy to analysis of chlorophylls, ESR of pi cations and anions of porphyrins as well as porphyrin excited states, and electron paramagnetic resonance and Mossbauer spectra of hemoproteins. The reader is also introduced to ESR and the electronic structure of metalloporphyrins. A chapter on Mossbauer spectroscopy of iron porphyrins concludes the book. This book is a valuable resource for inorganic, organic, physical, and biochemists interested in the physical chemistry of porphyrins.







Fundamentals of Porphyrin Chemistry


Book Description

FUNDAMENTALS OF PORPHYRIN CHEMISTRY An indispensable and concise overview of the chemistry of porphyrins and related molecules In Fundamentals of Porphyrin Chemistry: A 21st Century Approach, a team of distinguished researchers delivers a compact and accessible introduction to the broad field of porphyrin chemistry. It discusses the basics of porphyrin synthesis and structure, as well as that of related molecules, and the current and future roles that porphyrins play in chemical transformations, materials design and synthesis, energy capture and transduction, human health, and the environment. This edited volume is a self-contained tutorial on concepts of critical importance to porphyrin chemistry and serves as the foundation for discussions about the applications of porphyrin-related compounds found in the second volume. This book contains: A thorough introduction to porphyrins, including their structure, nomenclature, naturally occurring porphyrins, synthetic porphyrins, and common families of porphyrin-related compounds Comprehensive explorations of chemical porphyrin synthesis, including how to synthesize porphyrins from simple, symmetric, and advanced ABCD-substituted porphyrins Practical discussions of the physical characteristics of porphyrins, including their structural features, electronic structure, spectroscopy, magnetism, electrochemistry, and electron transfer processes Perfect for experienced academic researchers in the field of porphyrin chemistry seeking a quick reference, Fundamentals of Porphyrin Chemistry: A 21st Century Approach is also an indispensable resource for researchers new to the field who need an overview directing them to literature in more focused areas.







Progress in Inorganic Chemistry, Volume 7


Book Description

This comprehensive series of volumes on inorganic chemistry provides inorganic chemists with a forum for critical, authoritative evaluations of advances in every area of the discipline. Every volume reports recent progress with a significant, up-to-date selection of papers by internationally recognized researchers, complemented by detailed discussions and complete documentation. Each volume features a complete subject index and the series includes a cumulative index as well.




Towards Dual and Targeted Cancer Therapy with Novel Phthalocyanine-based Photosensitizers


Book Description

Janet Lau's thesis describes her studies into the use of phthalocyanine-based photosensitizers in combined chemo- and photodynamic therapy (PDT) and targeted PDT. In order to carry out this study, Lau uses several approaches: conjugation with a chemotherapeutic oxaliplatin derivative, use of a polyamine ligand 2 with a view to targeting the polyamine transporters over-expressed in tumor cells, and employment of a quencher that can inhibit their photodynamic activity but can still be removed under a tumor-associated environment such as low pH and high thiol concentration. This thesis reports dual activatable photosensitizers for the first time. Overall the studies included are original and the effects have been well demonstrated at the cellular level. The work in this thesis is of much current interest and importance, and can pave foundation for further developments. Accordingly, part of the results has been published in prestigious scientific journals.







The Porphyrins


Book Description