Author : Molly Weaver
Publisher :
Page : 436 pages
File Size : 43,45 MB
Release : 2003
Category : Cellular control mechanisms
ISBN :
Author : Julie F. Deimling
Publisher :
Page : 0 pages
File Size : 28,72 MB
Release : 1999
Category :
ISBN :
Interactions between the pulmonary epithelium and its surrounding mesenchyme are critical for regulating developmental processes during early lung development. However, less is known about the importance of these tissue interactions during late lung development. In this study we employed a novel cell recombination model to examine the role of epithelial-mesenchymal interactions in both lung epithelial morphogenesis and cellular differentiation during late fetal gestation. Results suggest that at late fetal gestation, lung epithelial cells are not fully committed to a specific phenotype and still have the plasticity to respond to various signals originating from the surrounding mesenchyme. We have also begun to investigate a potential role for the Notch signaling pathway in mammalian lung development. The Notch pathway is an evolutionarily conserved mechanism for regulating cell differentiation in populations of equipotent cells. Since there must be mechanisms which control the specification of lung epithelial cell fate during lung development, we analyzed the spatial and temporal mRNA expression patterns of some of the Notch receptors, ligands and various pathway mediators, by non-radioactive 'in situ' hybridization. (Abstract shortened by UMI.).
Author : Alan H. Jobe
Publisher : Cambridge University Press
Page : pages
File Size : 27,43 MB
Release : 2016-04-18
Category : Medical
ISBN : 1316665178
Lung disease affects more than 600 million people worldwide. While some of these lung diseases have an obvious developmental component, there is growing appreciation that processes and pathways critical for normal lung development are also important for postnatal tissue homeostasis and are dysregulated in lung disease. This book provides an authoritative review of fetal and neonatal lung development and is designed to provide a diverse group of scientists, spanning the basic to clinical research spectrum, with the latest developments on the cellular and molecular mechanisms of normal lung development and injury-repair processes, and how they are dysregulated in disease. The book covers genetics, omics, and systems biology as well as new imaging techniques that are transforming studies of lung development. The reader will learn where the field of lung development has been, where it is presently, and where it is going in order to improve outcomes for patients with common and rare lung diseases.
Author : Sengel
Publisher : CUP Archive
Page : 296 pages
File Size : 17,77 MB
Release : 1976
Category : Medical
ISBN : 9780521206440
Author : Roger H. Sawyer
Publisher : Greenwood
Page : 280 pages
File Size : 33,77 MB
Release : 1983
Category : Science
ISBN :
Author : Claude Gaultier
Publisher : Springer
Page : 464 pages
File Size : 46,7 MB
Release : 2013-05-27
Category : Medical
ISBN : 1461475376
Knowledge about the mechanisms of lung development has been growing rapidly, especially with regard to cellular and molecular aspects of growth and differentiation. This authoritative international volume reviews key aspects of lung development in health and disease by providing a comprehensive review of the complex series of cellular and molecular interactions required for lung development. It covers such topics as pulmonary hypoplasia, effects of malnutrition, and pulmaonary angiogenesis. An indispensable reference for all those involved in studying or treating lung disease in neonates and children, the book offers a unique view of the development of this essential organ.
Author : Gabriel G. Haddad
Publisher : PMPH-USA
Page : 568 pages
File Size : 20,90 MB
Release : 2002
Category : Children
ISBN : 9781550091595
This second edition of the landmark 1991 text, Basic Mechanisms of Pediatric Respiratory Disease reviews the importance of the integrations of molecular, cellular and physiologic strategies in the development of a new understanding of pediatric respiratory disorders. It provides state-of-the-art information about fundamental mechanisms underlying ......
Author : Jamie Davies
Publisher : Springer Science & Business Media
Page : 255 pages
File Size : 20,12 MB
Release : 2007-03-20
Category : Science
ISBN : 0387308733
Branching morphogenesis, the creation of branched structures in the body, is a key feature of animal and plant development. This book brings together, for the first time, expert researchers working on a variety of branching systems to present a state-of-the-art view of the mechanisms that control branching morphogenesis. Systems considered range from single cells, to blood vessel and drainage duct systems to entire body plans, and approaches range from observation through experiment to detailed biophysical modelling. The result is an integrated overview of branching.
Author : Toshio Nakanishi
Publisher : Springer Nature
Page : 374 pages
File Size : 36,29 MB
Release : 2020-02-28
Category : Medical
ISBN : 9811511853
This open access book focuses on the molecular mechanism of congenital heart disease and pulmonary hypertension, offering new insights into the development of pulmonary circulation and the ductus arteriosus. It describes in detail the molecular mechanisms involved in the development and morphogenesis of the heart, lungs and ductus arteriosus, covering a range of topics such as gene functions, growth factors, transcription factors and cellular interactions, as well as stem cell engineering technologies. The book also presents recent advances in our understanding of the molecular mechanism of lung development, pulmonary hypertension and molecular regulation of the ductus arteriosus. As such, it is an ideal resource for physicians, scientists and investigators interested in the latest findings on the origins of congenital heart disease and potential future therapies involving pulmonary circulation/hypertension and the ductus arteriosus.
Author : Pierre Savagner
Publisher : Springer Science & Business Media
Page : 341 pages
File Size : 49,8 MB
Release : 2007-07-05
Category : Science
ISBN : 0387286713
Epithelial phenotype is a dynamic stage of differentiation that can be modulated during several physiological or pathological events. The rapid conversion to a mesenchymal-like phenotype is called an epithelial-mesenchymal transition (EMT). The Rise and Fall of Epithelial Phenotype is the first book to comprehensively introduce the concept of EMT. The first part of this volume describes main examples and models and explains their physiological relevance. These examples include hydra morphogenesis, gastrulation in mouse, drosophila and sea urchin, as well as neural crest cell migration and heart morphogenesis in vertebrates. Part two reviews in detail, specific EMT molecular pathways covering extracellular induction, transduction and transcription response and modulation of cell-cell adhesion structures. It emphasizes new specific pathways with potential medical applications. EMTs can also be linked to pathological events such as wound healing and cancer progression, as detailed in this section of the book.
