The Structure of Biological Science


Book Description

Preface p. ix Chapter 1 Biology and Its Philosophy p. 2 1.1 The Rise of Logical Positivism p. 2 1.2 The Consequences for Philosophy p. 4 1.3 Problems of Falsifiability p. 6 1.4 Philosophy of Science Without Positivism p. 8 1.5 Speculation and Science p. 10 Introduction to the Literature p. 11 Chapter 2 Autonomy and Provincialism p. 13 2.1 Philosophical Agendas versus Biological Agendas p. 13 2.2 Motives for Provincialism and Autonomy p. 18 2.3 Biological Philosophies p. 21 2.4 Tertium Datur? p. 25 2.5 The Issues in Dispute p. 30 2.6 Steps in the Argument p. 34 Introduction to the Literature p. 35 Chapter 3 Teleology and the Roots of Autonomy p. 37 3.1 Functional Explanations in Molecular Biology p. 39 3.2 The Search for Functions p. 43 3.3 Functional Laws p. 47 3.4 Directively Organized Systems p. 52 3.5 The Autonomy of Teleological Laws p. 59 3.6 The Metaphysics and Epistemology of Functional Explanation p. 62 3.7 Functional Explanation Will Always Be with Us p. 65 Introduction to the Literature p. 67 Chapter 4 Reductionism and the Temptation of Provincialism p. 69 4.1 Motives for Reductionism p. 69 4.2 A Triumph of Reductionism p. 73 4.3 Reductionism and Recombinant DNA p. 84 4.4 Antireductionism and Molecular Genetics p. 88 4.5 Mendel's Genes and Benzer's Cistrons p. 93 4.6 Reduction Obstructed p. 97 4.7 Qualifying Reductionism p. 106 4.8 The Supervenience of Mendelian Genetics p. 11 4.9 Levels of Organization p. 117 Introduction to the Literature p. 119 Chapter 5 The Structure of Evolutionary Theory p. 121 5.1 Is There an Evolutionary Theory? p. 122 5.2 The Charge of Tautology p. 126 5.3 Population Genetics and Evolution p. 130 5.4 Williams's Axiomatization of Evolutionary Theory p. 136 5.5 Adequacy of the Axiomatization p. 144 Introduction to the Literature p. 152 Chapter 6 Fitness p. 154 6.1 Fitness Is Measured by Its Effects p. 154 6.2 Fitness As a Statistical Propensity p. 160 6.3 The Supervenience of Fitness p. 164 6.4 The Evidence for Evolution p. 169 6.5 The Scientific Context of Evolutionary Theory p. 174 Introduction to the Literature p. 179 Chapter 7 Species p. 180 7.1 Operationalism and Theory in Taxonomy p. 182 7.2 Essentialism--For and Against p. 187 7.3 The Biological Species Notion p. 191 7.4 Evolutionary and Ecological Species p. 197 7.5 Species Are Not Natural Kinds p. 201 7.6 Species As Individuals p. 204 7.7 The Theoretical Hierarchy of Biology p. 212 7.8 The Statistical Character of Evolutionary Theory p. 216 7.9 Universal Theories and Case Studies p. 219 Introduction to the Literature p. 225 Chapter 8 New Problems of Functionalism p. 226 8.1 Functionalism in Molecular Biology p. 228 8.2 The Panglossian Paradigm p. 235 8.3 Aptations, Exaptations, and Adaptations p. 243 8.4 Information and Action Among the Macromolecules p. 246 8.5 Metaphors and Molecules p. 255 Bibliography p. 266 Index p. 273.




Levels of Organization in the Biological Sciences


Book Description

Scientific philosophers examine the nature and significance of levels of organization, a core structural principle in the biological sciences. This volume examines the idea of levels of organization as a distinct object of investigation, considering its merits as a core organizational principle for the scientific image of the natural world. It approaches levels of organization--roughly, the idea that the natural world is segregated into part-whole relationships of increasing spatiotemporal scale and complexity--in terms of its roles in scientific reasoning as a dynamic, open-ended idea capable of performing multiple overlapping functions in distinct empirical settings. The contributors--scientific philosophers with longstanding ties to the biological sciences--discuss topics including the philosophical and scientific contexts for an inquiry into levels; whether the concept can actually deliver on its organizational promises; the role of levels in the development and evolution of complex systems; conditional independence and downward causation; and the extension of the concept into the sociocultural realm. Taken together, the contributions embrace the diverse usages of the term as aspects of the big picture of levels of organization. Contributors Jan Baedke, Robert W. Batterman, Daniel S. Brooks, James DiFrisco, Markus I. Eronen, Carl Gillett, Sara Green, James Griesemer, Alan C. Love, Angela Potochnik, Thomas Reydon, Ilya Tëmkin, Jon Umerez, William C. Wimsatt, James Woodward




Fundamentals of Molecular Structural Biology


Book Description

Fundamentals of Molecular Structural Biology reviews the mathematical and physical foundations of molecular structural biology. Based on these fundamental concepts, it then describes molecular structure and explains basic genetic mechanisms. Given the increasingly interdisciplinary nature of research, early career researchers and those shifting into an adjacent field often require a "fundamentals" book to get them up-to-speed on the foundations of a particular field. This book fills that niche.







An Introduction to Biological Membranes


Book Description

Introduction to Biological Membranes: Composition, Structure and Function, Second Edition is a greatly expanded revision of the first edition that integrates many aspects of complex biological membrane functions with their composition and structure. A single membrane is composed of hundreds of proteins and thousands of lipids, all in constant flux. Every aspect of membrane structural studies involves parameters that are very small and fast. Both size and time ranges are so vast that multiple instrumentations must be employed, often simultaneously. As a result, a variety of highly specialized and esoteric biochemical and biophysical methodologies are often utilized. This book addresses the salient features of membranes at the molecular level, offering cohesive, foundational information for advanced undergraduate students, graduate students, biochemists, and membranologists who seek a broad overview of membrane science. - Significantly expanded coverage on function, composition, and structure - Brings together complex aspects of membrane research in a universally understandable manner - Features profiles of membrane pioneers detailing how contemporary studies originated - Includes a timeline of important discoveries related to membrane science




Concepts of Biology


Book Description

Black & white print. Concepts of Biology is designed for the typical introductory biology course for nonmajors, covering standard scope and sequence requirements. The text includes interesting applications and conveys the major themes of biology, with content that is meaningful and easy to understand. The book is designed to demonstrate biology concepts and to promote scientific literacy.




Biological Materials Science


Book Description

Takes a materials science approach, correlating structure-property relationships with function across a broad range of biological materials.




Research at the Intersection of the Physical and Life Sciences


Book Description

Traditionally, the natural sciences have been divided into two branches: the biological sciences and the physical sciences. Today, an increasing number of scientists are addressing problems lying at the intersection of the two. These problems are most often biological in nature, but examining them through the lens of the physical sciences can yield exciting results and opportunities. For example, one area producing effective cross-discipline research opportunities centers on the dynamics of systems. Equilibrium, multistability, and stochastic behavior-concepts familiar to physicists and chemists-are now being used to tackle issues associated with living systems such as adaptation, feedback, and emergent behavior. Research at the Intersection of the Physical and Life Sciences discusses how some of the most important scientific and societal challenges can be addressed, at least in part, by collaborative research that lies at the intersection of traditional disciplines, including biology, chemistry, and physics. This book describes how some of the mysteries of the biological world are being addressed using tools and techniques developed in the physical sciences, and identifies five areas of potentially transformative research. Work in these areas would have significant impact in both research and society at large by expanding our understanding of the physical world and by revealing new opportunities for advancing public health, technology, and stewardship of the environment. This book recommends several ways to accelerate such cross-discipline research. Many of these recommendations are directed toward those administering the faculties and resources of our great research institutions-and the stewards of our research funders, making this book an excellent resource for academic and research institutions, scientists, universities, and federal and private funding agencies.




Biological Inorganic Chemistry


Book Description

The importance of metals in biology, the environment and medicine has become increasingly evident over the last twenty five years. The study of the multiple roles of metal ions in biological systems, the rapidly expanding interface between inorganic chemistry and biology constitutes the subject called Biological Inorganic Chemistry. The present text, written by a biochemist, with a long career experience in the field (particularly iron and copper) presents an introduction to this exciting and dynamic field. The book begins with introductory chapters, which together constitute an overview of the concepts, both chemical and biological, which are required to equip the reader for the detailed analysis which follows. Pathways of metal assimilation, storage and transport, as well as metal homeostasis are dealt with next. Thereafter, individual chapters discuss the roles of sodium and potassium, magnesium, calcium, zinc, iron, copper, nickel and cobalt, manganese, and finally molybdenum, vanadium, tungsten and chromium. The final three chapters provide a tantalising view of the roles of metals in brain function, biomineralization and a brief illustration of their importance in both medicine and the environment.Relaxed and agreeable writing style. The reader will not only fiind the book easy to read, the fascinating anecdotes and footnotes will give him pegs to hang important ideas on.Written by a biochemist. Will enable the reader to more readily grasp the biological and clinical relevance of the subject.Many colour illustrations. Enables easier visualization of molecular mechanismsWritten by a single author. Ensures homgeneity of style and effective cross referencing between chapters




Biological Science


Book Description

Biological Science: Exploring the Science of Life responds to the key needs of lecturers and their students by placing a clear central narrative, carefully-structured active learning, and confidence with quantitative concepts and scientific enquiry central to its approach.Written by a team of dedicated and passionate academics, and shaped by feedback from over 55 institutions, its straightforward narrative, reinforced by key concept overview videos for every chapter, communicate key ideas clearly: the right information is provided at the right time, and at the rightdepth.Its pause and think features, self-check quizzes, and graded end of chapter questions, augmented by flashcards of key terms, directly support active learning. The combination of narrative text and learning features promote a rich, active learning experience: read, watch, and do.Its combination of Quantitative Toolkits, Scientific Process panels, and the Life and its Exploration chapters provide more insight and support than any other general biology text; they prepare students to engage with this quantitative and experimental discipline with confidence, and set them on apath for success throughout their future studies.With coverage that spans the full scale of biological science - from molecule to ecosystem - and with an approach that fully supports flexible, self-paced learning, Biological Science: Exploring the Science of Life will set you on a path towards a deeper understanding of the key concepts inbiology, and a greater appreciation of biology as a dynamic experimental science.Digital formats and resourcesBiological Science: Exploring the Science of Life is available for students and institutions to purchase in a variety of formats.The enhanced ebook is enriched with features that offer extra learning support: www.oxfordtextbooks.co.uk/ebooks- Key concepts videos support students from the start of every chapter and as they make their way through every Module.- Self-check questions at the end of each chapter section give students quick and formative feedback, building their confidence and comprehension as they study and revise.- Quantitative skills video screencasts help students to master the foundational skills required by this discipline.- Interactive figures give students the control they need to step through, and gain mastery over, key concepts.- Per-chapter flashcard glossaries help students to recall the key terms and concepts on which further study can be built.