The Wernicke-Korsakoff Syndrome and Related Neurologic Disorders Due to Alcoholism and Malnutrition


Book Description

The major text on Korsakoff's syndrome and Wernicke's encephalopathy. Appearing many years after the first edition in 1971, this revision carries far more clinical experience and allows comment upon nonalcoholic patients--in many of whom the disease was iatrogenic. Much is new: thiamine deficiency and the nervous system, Korsakoff amnesic state, and so-called alcoholic cerebral atrophy. Annotation copyrighted by Book News, Inc., Portland, OR




Alcohol and the Nervous System


Book Description

Alcohol is the most widely used drug in the world, yet alcoholism remains a serious addiction affecting nearly 20 million Americans. Our current understanding of alcohol's effect on brain structure and related functional damage is being revolutionized by genetic research, basic neuroscience, brain imaging science, and systematic study of cognitive, sensory, and motor abilities. Volume 125 of the Handbook of Clinical Neurology is a comprehensive, in-depth treatise of studies on alcohol and the brain covering the basic understanding of alcohol's effect on the central nervous system, the diagnosis and treatment of alcoholism, and prospect for recovery. The chapters within will be of interest to clinical neurologists, neuropsychologists, and researchers in all facets and levels of the neuroscience of alcohol and alcoholism. - The first focused reference specifically on alcohol and the brain - Details our current understanding of how alcohol impacts the central nervous system - Covers clinical and social impact of alcohol abuse disorders and the biomedical consequences of alcohol abuse - Includes section on neuroimaging of neurochemical markers and brain function




Neurologic Consequences of Malnutrition


Book Description

Nearly 800 million people in the world do not have enough to eat. In many developing countries, inadequate amounts of food and inadequate diversity of food continue to be priority health problems. Malnutrition in all its forms increases the risk of disease and early death. Neurologic Consequences of Malnutrition, edited by Dr. Marco T. Medina, seeks to underline the magnitude of neurologic diseases related to malnutrition and the importance of early detection and opportune treatment. Designed particularly for neurologists practicing in low-resource environments, this text is written by a multinational group of expert practicing neurologists who treat patients suffering from the neurologic consequence of malnutrition. Neurologic Consequences of Malnutrition begins with an overview of the epidemiology and incidence of malnutrition and neurologic disorders. There is a discussion of the clinical and functional assessment of undernourished patients, focusing on patients with Protein-Energy Malnutrition, as well as an extensive and complete classification of the different micronutrient deficiencies related to neurologic symptoms. Other topics covered include the relationship between alcoholism and malnutrition, a major public health challenge in developing nations, and the neurophysiologic findings in undernourished patients.




A CASE OF NON ALCOHOLIC WERNICKE KORSAKOFF SYNDROME RESULTING FROM MALNUTRITION DUE TO PSYCHOSIS


Book Description

Objectives:1. To report a case of Non-Alcoholic Wernicke Korsakof Syndrome (WKS) that apparently resulted from malnutrition due to psychosis.2. To make a brief literature review on Non Alcoholic WKS.Background:WKS consists of two closely interrelated entities that represent different stages of the same pathophysiological process. Wernicke's Encephalopathy (WE) is a brain disease that results from thiamine deficit. If early detection and replenishment with thiamine is accomplished WE can be inoffensive. Korsakoff Syndrome, characterized by anterograde and retrograde amnesia in addition to other neurocognitive and psychopathological manifestations such as confabulations, occurs after an untreated WE, and in most of the cases itu00b4s irreversible.Materials and Methods:Case description with clinical information provided by the patient, his relatives and from his medical records. Presentation of his cranial magnetic resonance images. Non-systematic review of the literature (MEDLINE) on WKS.Results and Conclusions:We describe the case of a 42 years old male patient, without personal history of alcohol abuse who was admitted in a psychiatry ward with clinical and imaging diagnose of WKS. This WKS was found to result from malnutrition due to psychosis. Unfortunately even after thiamine reposition the patient was discharged maintaining cognitive and neurologic deficits.WKS is a serious, preventable and reversible disease but can have serious repercussions, from permanent neurocognitive deficits to death. It can occur in any condition that causes thiamine deficiency having already been identified after several organic and psychiatric diseases.We should therefore be watchful to the signs and symptoms of WKS, independently of the presence or absence of history of alcohol consumption.




Addictive Substances and Neurological Disease


Book Description

Addictive Substances and Neurological Disease: Alcohol, Tobacco, Caffeine, and Drugs of Abuse in Everyday Lifestyles is a complete guide to the manifold effects of addictive substances on the brain, providing readers with the latest developing research on how these substances are implicated in neurological development and dysfunction. Cannabis, cocaine, and other illicit drugs can have substantial negative effects on the structure and functioning of the brain. However, other common habituating and addictive substances often used as part of an individual’s lifestyle, i.e., alcohol, tobacco, caffeine, painkillers can also compromise brain health and effect or accentuate neurological disease. This book provides broad coverage of the effects of addictive substances on the brain, beginning with an overview of how the substances lead to dysfunction before examining each substance in depth. It discusses the pathology of addiction, the structural damage resulting from abuse of various substances, and covers the neurobiological, neurodegenerative, behavioral, and cognitive implications of use across the lifespan, from prenatal exposure, to adolescence and old age. This book aids researchers seeking an understanding of the neurological changes that these substances induce, and is also extremely useful for those seeking potential treatments and therapies for individuals suffering from chronic abuse of these substances. Integrates current research on the actions of addictive substances in neurological disease Includes functional foods, such as caffeine beverages, that have habituating effects on the brain Provides a synopsis of key ideas associated with the consequences of addictive and habituating lifestyle substances




NORD Guide to Rare Disorders


Book Description

NORD Guide to Rare Disorders is a comprehensive, practical, authoritative guide to the diagnosis and management of more than 800 rare diseases. The diseases are discussed in a uniform, easy-to-follow format--a brief description, signs and symptoms, etiology, related disorders, epidemiology, standard treatment, investigational treatment, resources, and references.The book includes a complete directory of orphan drugs, a full-color atlas of visual diagnostic signs, and a Master Resource List of support groups and helpful organizations. An index of symptoms and key words offers physicians valuable assistance in finding the information they need quickly.




Alcohol and the Brain


Book Description

Chronic and excessive alcohol consumption disrupts a number of biologic sys tems. Central nervous system pathology, associated with long-standing alcohol ingestion, has particularly deleterious consequences to the individual. Compro mising brain functional integrity ultimately militates against psychosocial ad justment, and this process is inevitably reflected as a substantial economic loss to society in the form of costs for providing medical and social services, as well as disability and absenteeism from work. This book marshals the literature pertinent to the effects of chronic alcohol abuse on brain structure and functioning. The material is divided into two parts: basic research and clinical issues. In the first section, the manifest neurologic consequences are described across the different levels of biologic organization, these being brain morphology, neurochemistry, neurophysiology, and neuro psychology. In recognition of the multifactorial etiology of alcohol-related brain pathology, the influence and role of hepatic, endocrine, and nutritional factors are also examined. The second section addresses clinical syndromes and dis orders. It will be noted that evidence accrued from recent research suggests that neurologic disturbances may actually antedate the onset of drinking in some alcoholics. Other clinically important issues discussed are the effects of alcohol on neurologic development, aging, and dementia. The book concludes with a discussion of the alcohol withdrawal syndrome, its mechanisms and manifes tations. A fundamental objective of the editors was to illustrate that the consequences of chronic alcohol excess can be comprehensively understood within the per spective of interrelated hierarchical systems of brain organization.




The Confabulating Mind


Book Description

This new edition gives an up-to-date account of the causes, anatomical basis, and mechanisms of confabulations. It traces the history of the phenomenon of false memories, considers a range of clinical cases, and makes important recommendations for future study. It is essential for neurologists, psychiatrists, and cognitive neuroscientists.




Cerebellar Disorders


Book Description

During the last three decades, many laboratories worldwide have dedicated their research activities to understanding the roles of the cerebellum in motor control, cognitive processes and the biology of mental processes, behavioral symptoms and emotion. These advances have been associated with discoveries of new clinical disorders, in particular in the field of genetic ataxias, and the growing number of diseases presents a source of difficulty for clinicians during daily practice. This practical guide summarizes and evaluates current knowledge in the field of cerebellar disorders. Encompassing details of both common and uncommon cerebellar ataxias, including vascular, immune, neoplastic, infectious, traumatic, toxic and inherited disorders, this book will assist clinicians in the diagnosis and management of the full spectrum of cerebellar ataxias encountered in daily practice. Essential reading for clinicians, including general practitioners, neurologists, pediatricians, radiologists, psychiatrists and neuropsychologists, this will also prove a valuable tool for students, trainees and researchers.




The Oxford Handbook of Adult Cognitive Disorders


Book Description

The prevalence of adult cognitive disorders will dramatically rise over the next 25 years due to the aging population. Clinical research on adult cognitive disorders has rapidly evolved, including evidence of new adult cognitive disorders and greater insight into the clinical presentation, mechanism, diagnosis, and treatment of established diseases. The Oxford Handbook of Adult Cognitive Disorders is an up-to-date, scholarly, and comprehensive volume covering most diseases, conditions, and injuries resulting in impairments in cognitive function in adults. Topics covered include normal cognitive and brain aging, the impact of medical disorders and psychiatric illnesses on cognitive function, adult neurodevelopmental disorders, and various neurological conditions. This Handbook also provides a section on unique perspectives and special considerations for clinicians and clinical researchers, covering topics such as cognitive reserve, genetics, diversity, and neuroethics. Readers will be able to draw upon this volume to facilitate clinical practice (including differential diagnosis, treatment recommendations, assessment practices), and to obtain an in-depth review of current research across a wide spectrum of disorders, provided by leaders in their fields. The Oxford Handbook of Adult Cognitive Disorders is a one-of a kind resource appropriate for both clinicians and clinical researchers, from advanced trainees to seasoned professionals.