Author : Franziska Matthäus
Publisher : Springer Nature
Page : 152 pages
File Size : 49,52 MB
Release : 2020-04-16
Category : Science
ISBN : 3030334716
This beautifully crafted book collects images, which were created during the process of research in all fields of theoretical biology. Data analysis, numerical treatment of a model, or simulation results yield stunning images, which represent pieces of art just by themselves. The approach of the book is to present for each piece of visualization a lucid synopsis of the scientific background as well as an outline of the artistic vision.
Author : Erik Peterson
Publisher : University of Pittsburgh Press
Page : 327 pages
File Size : 33,74 MB
Release : 2016-12-23
Category : Science
ISBN : 082298198X
As scientists debated the nature of life in the nineteenth century, two theories predominated: vitalism, which suggested that living things contained a "vital spark," and mechanism, the idea that animals and humans differed from nonliving things only in their degree of complexity. Erik Peterson tells the forgotten story of the pursuit of a Third Way in biology, known by many names, including "the organic philosophy," which gave rise to C. H. Waddington's work in the subfield of epigenetics: an alternative to standard genetics and evolutionary biology that captured the attention of notable scientists from Francis Crick to Stephen Jay Gould. The Life Organic chronicles the influential biologists, mathematicians, philosophers, and biochemists from both sides of the Atlantic who formed Joseph Needham's Theoretical Biology Club, defined and refined Third-Way thinking through the 1930s, and laid the groundwork for some of the most cutting-edge achievements in biology today. By tracing the persistence of organicism into the twenty-first century, this book also raises significant questions about how we should model the development of the discipline of biology going forward.
Author : Brian Munsky
Publisher : MIT Press
Page : 729 pages
File Size : 47,49 MB
Release : 2018-08-21
Category : Science
ISBN : 0262038080
An introduction to the quantitative modeling of biological processes, presenting modeling approaches, methodology, practical algorithms, software tools, and examples of current research. The quantitative modeling of biological processes promises to expand biological research from a science of observation and discovery to one of rigorous prediction and quantitative analysis. The rapidly growing field of quantitative biology seeks to use biology's emerging technological and computational capabilities to model biological processes. This textbook offers an introduction to the theory, methods, and tools of quantitative biology. The book first introduces the foundations of biological modeling, focusing on some of the most widely used formalisms. It then presents essential methodology for model-guided analyses of biological data, covering such methods as network reconstruction, uncertainty quantification, and experimental design; practical algorithms and software packages for modeling biological systems; and specific examples of current quantitative biology research and related specialized methods. Most chapters offer problems, progressing from simple to complex, that test the reader's mastery of such key techniques as deterministic and stochastic simulations and data analysis. Many chapters include snippets of code that can be used to recreate analyses and generate figures related to the text. Examples are presented in the three popular computing languages: Matlab, R, and Python. A variety of online resources supplement the the text. The editors are long-time organizers of the Annual q-bio Summer School, which was founded in 2007. Through the school, the editors have helped to train more than 400 visiting students in Los Alamos, NM, Santa Fe, NM, San Diego, CA, Albuquerque, NM, and Fort Collins, CO. This book is inspired by the school's curricula, and most of the contributors have participated in the school as students, lecturers, or both. Contributors John H. Abel, Roberto Bertolusso, Daniela Besozzi, Michael L. Blinov, Clive G. Bowsher, Fiona A. Chandra, Paolo Cazzaniga, Bryan C. Daniels, Bernie J. Daigle, Jr., Maciej Dobrzynski, Jonathan P. Doye, Brian Drawert, Sean Fancer, Gareth W. Fearnley, Dirk Fey, Zachary Fox, Ramon Grima, Andreas Hellander, Stefan Hellander, David Hofmann, Damian Hernandez, William S. Hlavacek, Jianjun Huang, Tomasz Jetka, Dongya Jia, Mohit Kumar Jolly, Boris N. Kholodenko, Markek Kimmel, Michał Komorowski, Ganhui Lan, Heeseob Lee, Herbert Levine, Leslie M Loew, Jason G. Lomnitz, Ard A. Louis, Grant Lythe, Carmen Molina-París, Ion I. Moraru, Andrew Mugler, Brian Munsky, Joe Natale, Ilya Nemenman, Karol Nienałtowski, Marco S. Nobile, Maria Nowicka, Sarah Olson, Alan S. Perelson, Linda R. Petzold, Sreenivasan Ponnambalam, Arya Pourzanjani, Ruy M. Ribeiro, William Raymond, William Raymond, Herbert M. Sauro, Michael A. Savageau, Abhyudai Singh, James C. Schaff, Boris M. Slepchenko, Thomas R. Sokolowski, Petr Šulc, Andrea Tangherloni, Pieter Rein ten Wolde, Philipp Thomas, Karen Tkach Tuzman, Lev S. Tsimring, Dan Vasilescu, Margaritis Voliotis, Lisa Weber
Author : Thomas A.C. Reydon
Publisher : Springer Science & Business Media
Page : 312 pages
File Size : 40,68 MB
Release : 2005-12-05
Category : Science
ISBN : 1402029047
The present volume originated in 2001 when we, together with our publishing editors at (then) Kluwer Academic Publishers, realized that the th following year the 50 volume of our journal Acta Biotheoretica would see the light. We felt that this milestone should not pass unnoticed and that the appropriate way to mark it would be the publication of a special volume of papers on theoretical biology. While editing this book during 2003 and early 2004, we realized that another milestone was not far off: in 2005 it will be 70 years ago that the journal was founded. We hope that the book lying before you will serve well to mark both events. The papers collected here have been written on invitation by representatives of the theoretical biology community in The Netherlands. They are intended to reflect the entire spectrum of topics on which Acta Biotheoretica publishes, ranging from philosophy of biology on one end to mathematical biology on the other. All chapters (except our own introductory one) have been peer reviewed according to the standards that are maintained with respect to regular submissions to Acta Biotheoretica.
Author : James D. Murray
Publisher : Springer Science & Business Media
Page : 834 pages
File Size : 31,49 MB
Release : 2011-02-15
Category : Mathematics
ISBN : 0387952284
This richly illustrated third edition provides a thorough training in practical mathematical biology and shows how exciting mathematical challenges can arise from a genuinely interdisciplinary involvement with the biosciences. It has been extensively updated and extended to cover much of the growth of mathematical biology. From the reviews: ""This book, a classical text in mathematical biology, cleverly combines mathematical tools with subject area sciences."--SHORT BOOK REVIEWS
Author : Wilhelmina A. Leigh
Publisher : Taylor & Francis
Page : 360 pages
File Size : 27,80 MB
Release : 2017-07-12
Category : Science
ISBN : 1351490842
The purpose of this volume is to bring together a number of elements that would be useful in the construction of a coherent and comprehensive theory of biology. Based on the assumption that living systems represent some kind of "organized complexity," the collection discusses meaningful ways of formulating two basic questions: what is the nature of this complexity; and, what are the principles of its organization? The question always asked about biological theory is whether or not it constitutes useful scientific theory. Because many useful biological theories cannot yet be made explicit in terms of conventional physics, Sketching Theoretical Biology illustrates the types of questions in biology that correspond to the types of issues discussed in theoretical physics. This book, originally published in 1969, centers around a vigorous debate on the role played by metaphysical beliefs in determining scientific attitudes. The discussion covers heredity and evolution, cognitive processes and control processes, general property of hierarchies, and the current status of neo-Darwinism. Contributors include theoretical physicists, philosophers, neuroscientists, theoretical chemists, computer scientists, chemical engineers, geneticists and molecular biologists.
Author : Alvaro Moreno
Publisher : Springer
Page : 249 pages
File Size : 49,39 MB
Release : 2015-05-04
Category : Philosophy
ISBN : 9401798370
Since Darwin, Biology has been framed on the idea of evolution by natural selection, which has profoundly influenced the scientific and philosophical comprehension of biological phenomena and of our place in Nature. This book argues that contemporary biology should progress towards and revolve around an even more fundamental idea, that of autonomy. Biological autonomy describes living organisms as organised systems, which are able to self-produce and self-maintain as integrated entities, to establish their own goals and norms, and to promote the conditions of their existence through their interactions with the environment. Topics covered in this book include organisation and biological emergence, organisms, agency, levels of autonomy, cognition, and a look at the historical dimension of autonomy. The current development of scientific investigations on autonomous organisation calls for a theoretical and philosophical analysis. This can contribute to the elaboration of an original understanding of life - including human life - on Earth, opening new perspectives and enabling fecund interactions with other existing theories and approaches. This book takes up the challenge.
Author : Avner Friedman
Publisher : American Mathematical Soc.
Page : 112 pages
File Size : 47,86 MB
Release : 2018-06-14
Category : Mathematics
ISBN : 1470447150
The fast growing field of mathematical biology addresses biological questions using mathematical models from areas such as dynamical systems, probability, statistics, and discrete mathematics. This book considers models that are described by systems of partial differential equations, and it focuses on modeling, rather than on numerical methods and simulations. The models studied are concerned with population dynamics, cancer, risk of plaque growth associated with high cholesterol, and wound healing. A rich variety of open problems demonstrates the exciting challenges and opportunities for research at the interface of mathematics and biology. This book primarily addresses students and researchers in mathematics who do not necessarily have any background in biology and who may have had little exposure to PDEs.
Author : Horst R. Thieme
Publisher : Princeton University Press
Page : 564 pages
File Size : 23,54 MB
Release : 2018-06-05
Category : Science
ISBN : 0691187657
The formulation, analysis, and re-evaluation of mathematical models in population biology has become a valuable source of insight to mathematicians and biologists alike. This book presents an overview and selected sample of these results and ideas, organized by biological theme rather than mathematical concept, with an emphasis on helping the reader develop appropriate modeling skills through use of well-chosen and varied examples. Part I starts with unstructured single species population models, particularly in the framework of continuous time models, then adding the most rudimentary stage structure with variable stage duration. The theme of stage structure in an age-dependent context is developed in Part II, covering demographic concepts, such as life expectation and variance of life length, and their dynamic consequences. In Part III, the author considers the dynamic interplay of host and parasite populations, i.e., the epidemics and endemics of infectious diseases. The theme of stage structure continues here in the analysis of different stages of infection and of age-structure that is instrumental in optimizing vaccination strategies. Each section concludes with exercises, some with solutions, and suggestions for further study. The level of mathematics is relatively modest; a "toolbox" provides a summary of required results in differential equations, integration, and integral equations. In addition, a selection of Maple worksheets is provided. The book provides an authoritative tour through a dazzling ensemble of topics and is both an ideal introduction to the subject and reference for researchers.
Author : Frank E. Zachos
Publisher : Springer
Page : 227 pages
File Size : 40,76 MB
Release : 2016-10-05
Category : Science
ISBN : 3319449664
Frank E. Zachos offers a comprehensive review of one of today’s most important and contentious issues in biology: the species problem. After setting the stage with key background information on the topic, the book provides a brief history of species concepts from antiquity to the Modern Synthesis, followed by a discussion of the ontological status of species with a focus on the individuality thesis and potential means of reconciling it with other philosophical approaches. More than 30 different species concepts found in the literature are presented in an annotated list, and the most important ones, including the Biological, Genetic, Evolutionary and different versions of the Phylogenetic Species Concept, are discussed in more detail. Specific questions addressed include the problem of asexual and prokaryotic species, intraspecific categories like subspecies and Evolutionarily Significant Units, and a potential solution to the species problem based on a hierarchical approach that distinguishes between ontological and operational species concepts. A full chapter is dedicated to the challenge of delimiting species by means of a discrete taxonomy in a continuous world of inherently fuzzy boundaries. Further, the book outlines the practical ramifications for ecology and evolutionary biology of how we define the species category, highlighting the danger of an apples and oranges problem if what we subsume under the same name (“species”) is in actuality a variety of different entities. A succinct summary chapter, glossary and annotated list of references round out the coverage, making the book essential reading for all biologists looking for an accessible introduction to the historical, philosophical and practical dimensions of the species problem.
