Tigliane Diterpenoids
Author : A. Douglas Kinghorn
Publisher : Springer Nature
Page : 197 pages
File Size : 12,10 MB
Release :
Category :
ISBN : 3031671805
Author : A. Douglas Kinghorn
Publisher : Springer Nature
Page : 197 pages
File Size : 12,10 MB
Release :
Category :
ISBN : 3031671805
Author : A. Douglas Kinghorn
Publisher : Springer
Page : 258 pages
File Size : 46,82 MB
Release : 2016-07-05
Category : Science
ISBN : 3319331728
The first contribution reviews the phytochemical, chemical, and biological literature on members of the ingenane class of diterpenoids from their first isolation in 1968 through 2015, highlighting unresolved issues both common to phorboids and specific to ingenol derivatives. The biogenesis of ingenol is discussed in the light of the Jakupovic proposal of a dissection between the formation of the macrocyclic Euphorbia diterpenoids and the phorboids, and the clinical development of ingenol mebutate is chronicled in the light of its “reverse-pharmacology” focus. The second contribution offers a comprehensive view of the chemical wealth and the taxonomic problems currently impeding chemical and biological investigations of the genus Laurencia. It addresses the botanical description and the growth and population dynamics of the genus, as well as its chemical diversity and ecological relations; the secondary metabolites as well as their sources of isolation; and finally the biological activity.
Author : Bin Yu
Publisher : Elsevier
Page : 988 pages
File Size : 49,50 MB
Release : 2023-07-19
Category : Medical
ISBN : 044318612X
Privileged Scaffolds in Drug Discovery is the most complete and up-to-date work in the area. Covering a wide range of privileged structures, it is a perfect reference for scientists involved in targeted drug development. The editors recruited epserts from several prestigious Chinese institutions to cover the areas of antiviral drugs, chalcone, pyrimidine, (benz)imidazoles, natural product-derived privileged scaffolds, N-Sulfonyl carboxamides, kinase inhibitors, antitumor molecules, antineurodegenerative drugs, triazoles, oxazolidinone, indole and indoline scaffolds, tigliane diterpenoids, peptide and peptide-based drugs, quassinoids, and others including pseudonatural products, macrocycles, stable peptides and peptidomimetics. The book also explores scaffolds in drug molecules approved in recent years. Privileged Scaffolds in Drug Discovery is a complete reference for researchers in drug discovery and organic synthesis, in academic and corporate settings, who are investigating privileged structures upon which to base new drugs. Researchers in medicinal chemistry and chemical biology will also find the contents of this book valuable. - Provides wide coverage of privileged scaffolds in new drug discovery - Includes complex and diverse natural product scaffolds - Covers applications to peptides and peptide-based drugs
Author : Kenneth Duane Rice
Publisher :
Page : 706 pages
File Size : 46,66 MB
Release : 1993
Category : Pharmaceutical chemistry
ISBN :
Author : Suguru Tsuchimoto
Publisher : Springer
Page : 288 pages
File Size : 34,3 MB
Release : 2017-11-25
Category : Science
ISBN : 3319496530
This book presents the genetics and genomics of Jatropha, which is used for biofuel, and shows how plant genomics can be used to improve plant breeding. The utilization of plant biofuels is a promising solution to global issues such as the depletion of fossil fuels and resources and climate change. Jatropha curcas L. (jatropha) is a species of shrub belonging to the Euphorbiaceae family. Native to Mesoamerica, it is now grown widely in tropical and subtropical areas in America, Africa and Asia. The seed oil of Jatropha is a suitable source for biodiesel or bio jet fuel, and since it is not edible and can grow in semi-arid lands unsuitable for the cultivation of food crops, its production does not compete with that of food to inflate its price. The characteristics of this promising biofuel plant, however, have not been fully exploited in terms of breeding, mainly because of the lack of information on its genetics and genomics. The structure of the whole genome of Jatropha is analyzed, providing insights into on the plant’s genetic system and accelerating the molecular breeding process.
Author : Seyed Mohammad Nabavi
Publisher : Elsevier
Page : 878 pages
File Size : 15,49 MB
Release : 2020-03-04
Category : Science
ISBN : 0128164557
Recent Advances in Natural Products Analysis is a thorough guide to the latest analytical methods used for identifying and studying bioactive phytochemicals and other natural products. Chemical compounds, such as flavonoids, alkaloids, carotenoids and saponins are examined, highlighting the many techniques for studying their properties. Each chapter is devoted to a compound category, beginning with the underlying chemical properties of the main components followed by techniques of extraction, purification and fractionation, and then techniques of identification and quantification. Biological activities, possible interactions, levels found in plants, the effects of processing, and current and potential industrial applications are also included.
Author : Yongxian Cheng
Publisher : Springer Nature
Page : 351 pages
File Size : 50,57 MB
Release : 2024-02-02
Category : Science
ISBN : 9819973295
This book provides an overview of the new plant natural product skeletons discovered from 1999 to 2021. It categorizes these natural products by providing their names, source distributions, structural types, structure characteristics, and bioactivities. A total of 1373 plant products in 99 families are presented, which cover 36 different structure types within the Hypericaceae family of which the majority are alkaloid structures. In addition, it presents the biological profiling in the last 23 years by summarizing the biological activities and potential disadvantages. The new natural products skeleton presented are unprecedented structural scaffolds and could bring new opportunities for biological/pharmaceutical areas and provide new structure templates for synthetic chemists. This book helps readers gain in-depth insight into the past and recent trends of natural products; it also assists those interested in assessing the potential biological function of the natural products.
Author : Alexandros L. Zografos
Publisher : John Wiley & Sons
Page : 585 pages
File Size : 15,41 MB
Release : 2016-04-18
Category : Science
ISBN : 1118751736
Focusing on biosynthesis, this book provides readers with approaches and methodologies for modern organic synthesis. By discussing major biosynthetic pathways and their chemical reactions, transformations, and natural products applications; it links biosynthetic mechanisms and more efficient total synthesis. • Describes four major biosynthetic pathways (acetate, mevalonate, shikimic acid, and mixed pathways and alkaloids) and their related mechanisms • Covers reactions, tactics, and strategies for chemical transformations, linking biosynthetic processes and total synthesis • Includes strategies for optimal synthetic plans and introduces a modern molecular approach to natural product synthesis and applications • Acts as a key reference for industry and academic readers looking to advance knowledge in classical total synthesis, organic synthesis, and future directions in the field
Author : Christophe Wiart
Publisher : CRC Press
Page : 319 pages
File Size : 18,72 MB
Release : 2024-06-28
Category : Science
ISBN : 1040033350
Researchers in the field of natural product chemistry and pharmacology focus on discovering new drugs from medicinal plants. The medicinal plants of Sabah (North Borneo), many of which are found in all of Asia and the Pacific, represent a vast array of resources that could be used for the discovery of drugs and the development of cosmetics as well as functional food. No other book focuses on the medicinal plants from this part of the globe in such depth. The author is well known in natural products and this text will appeal to a global audience in presenting the botanical description, chemical constituents, pharmacology, pharmaceutical, cosmetic, and functional food potentials of these plants. Features: Describes in a phylogenetic order the habitats, distributions, botanical descriptions, local names, uses, chemical constituents, pharmacological activities, and toxic effects of more than 250 species of medicinal plants of Sabah Provides a selection of botanical plates of medicinal plants endemic to Sabah, hand-drawn by the author Provides comment sections to invite further research on the topic of the development of drugs, dietary products, and cosmetics from Sabah medicinal plants
Author : Christophe Wiart
Publisher : CRC Press
Page : 310 pages
File Size : 10,18 MB
Release : 2021-12-06
Category : Science
ISBN : 1000477266
Medicinal Plants in the Asia Pacific for Zoonotic Pandemics provides an unprecedented, comprehensive overview of the phylogeny, botany, ethnopharmacology, and pharmacology of more than 100 plants used in the traditional systems of Asia and Pacific medicine for the treatment of microbial infections. It discusses their actions and potentials against viruses, bacteria, and fungi that represent a threat of epidemic and pandemic diseases, with an emphasis on the molecular basis and cellular pathways. This book presents for each plant the scientific name, the botanical classification, traditional medicinal uses, active chemical constituents, and pharmacology. This volume is a critical reference for anyone involved in the discovery of leads for the development of lead molecules or phytopharmaceutical products for the prevention or treatment of pandemic viral, bacterial, or fungal infections. FEATURES Includes phylogenetic presentation of medicinal plants and a chemotaxonomical rationale of antiviral, antibacterial, and antifungal actions Discusses chemical structure–activity relationship, pharmacokinetics, and oral bioavailability of antimicrobial principles Introduces the molecular mechanism of natural products on viruses, bacteria, and fungi Contains a selection of botanical plates and useful bibliographic references This book is a useful research tool for postgraduates, academics, and the pharmaceutical, herbal, and nutrition industries. Medicinal Plants in the Asia Pacific for Zoonotic Pandemics includes commentary sections that invite further research and reflection on the fascinating and timely subject of the development of leads or herbals from Asia-Pacific medicinal plants to safeguard humanity against the forthcoming waves of viral, bacterial, or fungal pandemics. This book is an ideal reference text for medicinal plant enthusiasts.