Translational Radiation Oncology


Book Description

Translational Radiation Oncology covers the principles of evidence-based medicine and applies them to the design of translational research. The book provides valuable discussions on the critical appraisal of published studies and recent developments in radiation oncology, allowing readers to learn how to evaluate the quality of such studies with respect to measuring outcomes and make effective use of all types of evidence. By reading this book, researchers have access to a practical approach to help them navigate challenging considerations in study design and implementation. It is a valuable resource for researchers, oncologists and members of biomedical field who want to understand more about translational research applied to the field of radiation oncology. Translational medicine serves as an indispensable tool in grant writing and funding efforts, so understanding how to apply its principles to research is necessary to guarantee that results will be impactful to patients. Provides a clear process for understanding, designing, executing and analyzing clinical and translational research Presents practical, step-by-step guidance to help readers take ideas from the lab to the bedside Written by a team of oncologists, radiologists and clinical research experts that fully cover translational research in radiation oncology




Radiation Oncology


Book Description

Radiation Oncology provides residents, fellows, and clinicians with a practical, evidence-based guide to the current management of difficult cases in radiation oncology. Emphasis is on the management of those clinical challenges commonly seen in practice that the community practitioner would normally handle without outside referral. The book offers comparisons of treatment approaches to difficult situations, allowing the reader to compare their current treatment approach to that of experts and others in the community. Radiation Oncology is organized in seven sections corresponding to the major treatment areas of radiation oncology. Each section includes three cases to illustrate specific clinical challenges for which there is no clear treatment protocol. The case discussion includes an expert opinion on optimal management along with alternatives from a second academic expert's perspective and from a community practitioner's perspective. Radiation Oncology features: Evidence-based approach to difficult management challenges in radiation oncology Expert authors provide evidence assessment and management summaries through presentation of relevant cases Community practitioner reviewers ensure real-world relevance of each discussion Reviews the most relevant literature pertaining to the challenging scenarios clinicians encounter every day Management alternatives allow discussion of the full range of management options and specifics for difficult problems including hardline recommendations




Radiation Oncology Primer and Review


Book Description

Radiation Oncology Primer and Review describes the fundamental concepts, nomenclature and definitions of the field of radiation oncology that every trainee or practitioner needs to know. Divided into three sections, Radiation Oncology Primer and Review covers basic science, clinical science, and technical and planning issues to give the trainee a full overview of the core knowledge base of the field. Co-written by a former radiation oncology residency program director and a team of radiation oncology residents, the book is organized in concise sections and is amply illustrated to highlight key points and help the reader understand and retain major concepts. Treatment approaches consistent with published clinical trial protocols that define control/standard of care/consensus radiation treatment are included. In addition to serving as a primary introduction to the field, the book also offers a short review of fundamental concepts for the senior resident prior to written or oral examinations, and is a useful resource for the radiation oncology educator to develop teaching plans and quizzes. Chapter organization is based on the International Atomic Energy Agency Syllabus for the Education and Training of Radiation Oncologists, the syllabus endorsed by both the American Society for Radiation Oncology and the European Society for Therapeutic Radiology and Oncology. Features of Radiation Oncology Primer and Review: Integrates basic science, clinical science and technical concepts to provide the trainee with a complete introduction to the field of radiation oncology Is consistent with accepted training syllabus for radiation oncology professionals Offers a concise presentation with illustrations highlighting key poiints Provides key points for study and reviews Includes treatment approaches consistent with published clinical trial protocols that define control/standard of care/consensus radiation treatment Is a valuable review resource for board review "




Advances in Radiation Oncology


Book Description

This book concisely reviews important advances in radiation oncology, providing practicing radiation oncologists with a fundamental understanding of each topic and an appreciation of its significance for the future of radiation oncology. It explores in detail the impact of newer imaging modalities, such as multiparametric magnetic resonance imaging (MRI) and positron emission tomography (PET) using fluorodeoxyglucose (FDG) and other novel agents, which deliver improved visualization of the physiologic and phenotypic features of a given cancer, helping oncologists to provide more targeted radiotherapy and assess the response. Due consideration is also given to how advanced technologies for radiation therapy delivery have created new treatment options for patients with localized and metastatic disease, highlighting the increasingly important role of image-guided radiotherapy in treating systemic and oligometastatic disease. Further topics include the potential value of radiotherapy in enhancing immunotherapy thanks to the broader immune-stimulatory effects, how cancer stem cells and the tumor microenvironment influence response, and the application of mathematical and systems biology methods to radiotherapy.







Fundamentals of Radiation Oncology


Book Description

Fundamentals of Radiation Oncology: Physical, Biological, and Clinical Aspects, Fourth Edition, is written by a team of renowned experts. This book is a must-have resource for anyone practicing radiation oncology. From basic principles to more-advanced planning and delivery of radiation therapy to treat cancer, this book is a go-to resource for mastering the art and science of radiation oncology. Recent advances in SRS, SBRT, proton therapy, an immunotherapy New chapters on adaptive radiotherapy, and artificial intelligence in radiation therapy IMRT and IGRT techniques are covered in depth in all clinical chapters Latest landmark studies provide evidence-based rationale for recommended treatments Radiation treatment toxicity and its management




Advances in Radiation Oncology in Lung Cancer


Book Description

This is the second, completely updated edition of a comprehensive book in which many of the world’s leading lung cancer specialists discuss the recent advances in the radiation oncology of lung cancer and reflect on the latest research findings. The first three sections cover the basic science of lung cancer, clinical investigations, including histology and staging, and a wide range of fundamental treatment considerations. Current treatment strategies for small cell and non-small cell lung cancer are then explained and evaluated in detail, with due attention to novel approaches that promise further improvements in outcome. The various types of treatment-related toxicity are discussed, and quality of life studies and prognostic factors are also considered. After evaluating the latest technological and biological advances, including IMRT, IMAT, cyber knife treatment, and tomotherapy, the book concludes by thorough consideration of specific aspects of clinical research in lung cancer.




Frontiers in Radiation Oncology


Book Description

The mode of action by radiation is postulated to be the production of double strand breaks of DNA. The repair of double strand breaks occurs through non homologous end joining through acetylation of histone proteins by histone acetyltransferases (HATs). The fixation of double strand breaks through HAT inhibitors is a promising application for radiation sensitization in the clinic. P53 is a tumour suppressor gene and its mutation has been implicated in 60% of human cancers. As one of the pivotal anticancer genes, P53 controls the transcription and translation of a series of genes. The kinetics of DNA double strand break generation and their co relation to P53 status, ATM and ARF activation are computed and modelled for understanding the potential of such research.




Global Challenges in Radiation Oncology


Book Description

In the United States, much of the research is focused on developing new and very expensive technologies and drugs - often without a major therapeutic benefit. In resource limited countries, basic oncology care is frequently lacking. In addition, the benefits of various chemo-radiotherapy combinations for a number of malignancies are unknown as these populations have not been adequately investigated. For oncologists in these countries who have marginal to adequate resources, accrual to clinical trials is virtually non-existent to minimal, due to the complexities of their population and competing co-morbidities. As a result, there is a tremendous disparity in treatment outcomes for these populations, compared to those in developed countries. Therefore, we have asked a number of oncologists from different parts of the world to report their experience. Topics that will be covered include locally advanced breast and cervical cancer (India, South Africa), human resources for cancer control in India, systematic review of radiation resources in low and middle income countries, planning national radiotherapy services, building sustainable partnerships through the newly formed ICEC (International Cancer Export Corps), cancer disparities among American Indians, and training radiation oncologists in these under served parts of the world. Authors will discuss "lessons learned" from their populations, practical suggestions to address these disparities, and how we as a global oncology community can address, and mitigate these global challenges. The editorial by Dr. Coleman and myself highlights the invaluable contributions from our global contributors. Thank you for taking the time to read this special issue on global cancer disparities. We are all energized to begin addressing the needs of our cancer patients worldwide.