› › Tuneable Degradable Polymeric Micelles For Drug Delivery From Synthesis To Feasibility In Vivo

Non-Biological Complex Drugs

Author : Daan J.A. Crommelin

Publisher : Springer

Page : 390 pages

File Size : 33,27 MB

Release : 2015-06-24

Category : Medical

ISBN : 3319162411

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Book Description

The rise of bio- and nano-technology in the last decades has led to the emergence of a new and unique type of medicine known as non-biological complex drugs (NBCDs). This book illustrates the challenges associated with NBCD development, as well as the complexity of assessing the effects of manufacturing changes on innovator and follow-on batches of NBCDs. It also touches upon proven marketing authorization requirements for biosimilars that could be effective in evaluating follow-on NBCDs, including a demonstration of control over the manufacturing process and a need for detailed physico-chemical characterization and (pre)clinical tests. This book is meant to be used for years to come as a standard reference work for the development of NBCDs. Moreover, this book aims to stimulate discussions and further our thinking to ensure that decisions regarding the approval of complex drugs are made with relevant scientific data on the table.



Nanoarchitectonics in Biomedicine

Author : Alexandru Mihai Grumezescu

Publisher : William Andrew

Page : 724 pages

File Size : 38,82 MB

Release : 2019-03-20

Category : Science

ISBN : 0128172614

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Book Description

Nanoarchitectonics in Biomedicine describes this new area of nanoscience that has emerged as a major branch of nanoscience. The book brings together recent applications and discusses the advantages and disadvantages of each process, offering international perspectives on the technologies based on these findings. It offers new insights for nanoarchitectonics, starting with the currently used methods of synthesis and characterization of such materials, along with their biomedical applications. Authored by a wide range of international scientists, this volume shows how nanoarchitectonics is being used to create more efficient medical treatment solutions. Users will find this to be an important research resource for those wanting to learn more on the emerging topic of nanoarchitectonics in biomedical science. - Explores how design aspects, smart materials and personalized materials are used in biomedicine today - Offers global perspectives on how nanoarchitectonics is used in different regions - Presents an important research resource for those wanting to learn more on the emerging topic of nanoarchitectonics in biomedical science



A Handbook of Applied Biopolymer Technology

Author : Sanjay K Sharma

Publisher : Royal Society of Chemistry

Page : 501 pages

File Size : 11,16 MB

Release : 2011-06-20

Category : Technology & Engineering

ISBN : 1849733457

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Book Description

Scientists are conducting active research in different fields of engineering, science and technology by adopting the Green Chemistry Principles and methodologies to devise new processes, with a view to help protect and ultimately save the environment from further anthropogenic interruptions and damage. With this in mind, the book provides an up-to-date, coherently written and objectively presented set of chapters from eminent international researchers who are actively involved in academic and technological research in the synthesis, (bio)degradation, testing and applications of biodegradable polymers and biopolymers. This pool of the latest ideas, recent research and technological progress, together with a high level of thinking with a comprehensive perspective, makes the emerging field of biodegradable polymer science and engineering (or bio-based polymers) linked to environmental sustainability, the essence of this key publication. The handbook consists of chapters written and contributed by international experts from academia who are world leaders in research and technology in sustainability and biopolymer and biodegradable polymer synthesis, characterisation, testing and use. The book highlights the following areas: green polymers; biopolymers and bionanocomposites; biodegradable and injectable polymers; biodegradable polyesters; synthesis and physical properties; discovery and characterization of biopolymers; degradable bioelastomers, lactic acid based biodegradable polymers; enzymatic degradation of biodegradable polymers; biodegradation of polymers in the composting environment; recent development in biodegradable polymers; research and applications and biodegradable foams. The book is aimed at technical, research-orientated and marketing people in industry, universities and institutions. It will also be of value to the worldwide public interested in sustainability issues and biopolymer development as well as others interested in the practical means that are being used to reduce the environmental impacts of chemical processes and products, to further eco-efficiency, and to advance the utilization of renewable resources for a bio-based production and supplier chain. Readers will gain a comprehensive and consolidated overview of the immense potential and ongoing research in bio-based and biodegradable polymer science, engineering and technology to make the world greener.



Nanoparticles in Pharmacotherapy

Author : Alexandru Mihai Grumezescu

Publisher : William Andrew

Page : 632 pages

File Size : 41,11 MB

Release : 2019-04-10

Category : Science

ISBN : 0128165049

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Book Description

Nanoparticles in Pharmacotherapy explores the most recent findings on how nanoparticles are used in pharmacotherapy, starting with their synthesis, characterization and current or potential uses. This book is a valuable resource of recent scientific progress that includes the most cutting-edge applications of nanoparticles in pharmacotherapy. It is ideal for researchers, medical doctors and those in academia.



Polymers for Pharmaceutical and Biomedical Applications

Author : Vandana Patravale

Publisher : Elsevier

Page : 482 pages

File Size : 48,62 MB

Release : 2024-01-16

Category : Medical

ISBN : 0323954979

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Book Description

Polymers for Pharmaceutical and Biomedical Applications: Fundamentals, Selection, and Preparation supports the successful selection, design, and development of polymers with the required properties and performance for a range of advanced pharmaceutical and biomedical applications. The book begins by introducing polymers for pharmaceutical and biomedical applications, examining classification, basic properties, structures, and grades. This is followed by in-depth chapters focusing on synthesis and modification, characterization techniques, and dissolution and solubility of polymers for pharmaceutical applications. Key applications are then highlighted, with chapters explaining in detail the preparation of polymers for conventional dosage, modified drug delivery, conjugates, advanced drug and gene delivery, medical devices, pharmaceutical packaging, tissue engineering, artificial organs, and dentistry. Throughout the book, the aim is to provide accessible, step-by-step coverage, supported by diagrams and case studies. Finally, safety and regulatory aspects are discussed. This is a valuable resource for all those who are newly approaching the field of polymers and product development for pharmaceutical and biomedical applications. This includes researchers and advanced students across polymer science, pharmaceutical science, biomaterials, biomedicine, healthcare, and chemistry, and scientists and R&D professionals in an industrial setting. - Explains fundamental concepts relating to the synthesis, modification, and characterization of polymers - Guides the reader towards successful selection of polymer systems for specific target applications - Addresses key challenges in this field that are supported by case studies and regulatory information



Engineering Polymer Systems for Improved Drug Delivery

Author : Rebecca A. Bader

Publisher : John Wiley & Sons

Page : 395 pages

File Size : 31,86 MB

Release : 2014-01-17

Category : Social Science

ISBN : 1118747801

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Book Description

Polymers have played a critical role in the rational design and application of drug delivery systems that increase the efficacy and reduce the toxicity of new and conventional therapeutics. Beginning with an introduction to the fundamentals of drug delivery, Engineering Polymer Systems for Improved Drug Delivery explores traditional drug delivery techniques as well as emerging advanced drug delivery techniques. By reviewing many types of polymeric drug delivery systems, and including key points, worked examples and homework problems, this book will serve as a guide to for specialists and non-specialists as well as a graduate level text for drug delivery courses.



Single-Chain Polymer Nanoparticles

Author : José A. Pomposo

Publisher : John Wiley & Sons

Page : 504 pages

File Size : 12,67 MB

Release : 2017-08-18

Category : Technology & Engineering

ISBN : 3527806393

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Book Description

This first book on this important and emerging topic presents an overview of the very latest results obtained in single-chain polymer nanoparticles obtained by folding synthetic single polymer chains, painting a complete picture from synthesis via characterization to everyday applications. The initial chapters describe the synthetics methods as well as the molecular simulation of these nanoparticles, while subsequent chapters discuss the analytical techniques that are applied to characterize them, including size and structural characterization as well as scattering techniques. The final chapters are then devoted to the practical applications in nanomedicine, sensing, catalysis and several other uses, concluding with a look at the future for such nanoparticles. Essential reading for polymer and materials scientists, materials engineers, biochemists as well as environmental chemists.



Polymeric Micelles for Drug Delivery

Author : Prashant Kesharwani

Publisher : Woodhead Publishing

Page : 716 pages

File Size : 35,40 MB

Release : 2022-08-18

Category : Technology & Engineering

ISBN : 0323886299

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Book Description

Polymeric Micelles for Drug Delivery provides a comprehensive overview on the synthesis, characterization and application of polymeric micelles in drug delivery applications. The use of nanomedicines and carriers, such as polymeric micelles, has made it possible to deliver drugs, genes and therapeutic agents to localized disease sites to maximize clinical benefit while limiting unwanted side effects. This book thoroughly reviews the development and application of polymeric micelles for drug delivery, covering various polymer types and the synthesis, characterization and pharmacokinetics of different micelles. Subsequent chapters go on to look at the range of drug delivery applications of polymeric micelles – such as mucosal and transdermal – and the assorted stimuli-responsive micelles available. The book concludes with an important analysis of the environmental and regulatory aspects associated with micelle development and clinical translation. - Explores how polymeric micelles can be utilized in a range of different drug delivery approaches, from traditional oral delivery to ocular and dermal delivery - Describes the various polymer types used in the synthesis and characterization of polymeric micelles - Covers recent advances in polymeric micelles, such as drug co-delivery, triblock polymeric micelles, delivery of genetic materials, and more



Applications of Polymers in Drug Delivery

Author : Ambikanandan Misra

Publisher : Elsevier

Page : 594 pages

File Size : 40,15 MB

Release : 2020-10-02

Category : Technology & Engineering

ISBN : 0128226684

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Book Description

Applications of Polymers in Drug Delivery, Second Edition, provides a comprehensive resource for anyone looking to understand how polymeric materials can be applied to current, new, and emerging drug delivery applications. Polymers play a crucial role in modulating drug delivery and have been fundamental in the successful development of many novel drug delivery systems. This book describes the development of polymeric systems, ranging from conventional dosage forms to the most recent smart systems. Regulatory and intellectual property aspects as well as the clinical applicability of polymeric drug delivery systems are also discussed. The chapters are organized by specific delivery route, offering methodical and detailed coverage throughout. This second edition has been thoroughly revised to include the latest developments in the field. This is an essential book for researchers, scientists, and advanced students, in polymer science, drug delivery, pharmacology/pharmaceuticals, materials science, tissue engineering, nanomedicine, chemistry, and biology. In industry, this book supports scientists, R&D, and other professionals, working on polymers for drug delivery applications. - Explains how polymers can be prepared and utilized for all major drug delivery routes - Presents the latest advances, including drug targeting, polymeric micelles and polymersomes, and the delivery of biologicals and nucleic acid therapeutics - Includes appendices with in-depth information on pharmaceutical properties of polymers and regulatory aspects



Polymers for Biomedical Applications

Author : Anil Mahapatro

Publisher : American Chemical Society

Page : 442 pages

File Size : 39,77 MB

Release : 2008-04-17

Category : Medical

ISBN :

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Book Description

Research on applications of polymers for biomedical applications has increased dramatically to find improved medical plastics for this rapidly evolving field. This book brings together various aspects of recent research and developments within academia and industry related to polymers for biomedical applications.