Eukaryome Impact on Human Intestine Homeostasis and Mucosal Immunology


Book Description

Multiple demographic or economic parameters contribute to the origin of emerging infections, for example: poverty, urbanization, climate change, conflicts and population migrations. All these factors are a challenge to assess the impact (present and future) of parasitic diseases on public health. The intestine is a major target of these infections; it is a nutrient-rich environment harbouring a complex and dynamic population of 100 trillion microbes: the microbiome. Most researches on the microbiome focus on bacteria, which share the gut ecosystem with a population of uni- and multi cellular eukaryotic organisms that may prey on them. Our interest focuses on the families of eukaryotic microbes inhabiting the intestine, called “intestinal eukaryome”, that include fungi, protists and helminths. Knowledge on the reciprocal influence between the microbiome and the eukaryome, and on their combined impact on homeostasis and intestinal diseases is scanty and can be considered as an important emerging field. Furthermore, the factors that differentiate pathogenic eukaryotes from commensals are still unknown. This book presents an overview of the science presented and discussed in the First Eukaryome Congress held from October 16th to 18th, 2019 at the Pasteur Institute in Paris. This book covers the following topics: Phylogenetic, prevalence, and diversity of intestinal eukaryotic microbes; and their (still enigmatic) historical evolution and potential contributions to mucosal immune homeostasis. Integrative biology to study the molecular cell biology of parasite-host interactions and the multiple parameters underlining the infectious process. The exploitation of tissue engineering and microfluidics to establish three-dimensional (3D) systems that help to understand homeostasis and pathological processes in the human intestine.







Abscisic Acid: Metabolism, Transport and Signaling


Book Description

This book provides a comprehensive review of all aspects of the molecular and cell biology of abscisic acid (ABA) metabolism, transport and signal transduction, covering our current understanding of ABA as well as research trends. The agricultural significance of ABA metabolism, transport and signal transduction is also discussed. The phytohormone ABA regulates many aspects of plant development and plays a central role in plant adaptation to environmental stresses. Over the past few decades, considerable advances have been made in the study of ABA metabolism, transport and signal transduction, greatly deepening our understanding of the underlying mechanisms of ABA function at the molecular, cell and whole-plant level and helping us improve crops’ environmental tolerance. This book provides a valuable resource for researchers and advanced students interested in plant biology and agriculture.




Encyclopedia of Canonical Ḥadīth


Book Description

This encyclopedic work on Islam comprises English translations of all canonical ḥadīths, complete with their respective chains of transmission (isnāds). By conflating the variant versions of the same ḥadīth, the repetitiveness of its literature has been kept wherever possible to a minimum. The latest methods of isnād analysis, described in the general introduction, have been employed in an attempt to identify the person(s) responsible for each ḥadīth. The book is organized in the alphabetical order of those persons. These are the so-called ‘common links’. Each of them is listed with the tradition(s) for the wording of which he can be held accountable, or with which he can at least be associated. Within each article, the traditions are referred to in bold figures in the numerical order as they were distilled from the more than 19,000 isnāds listed in Tuḥfat al-ashrāf bi maʿrifat al-aṭrāf by the Syrian ḥadīth scholar Yusuf b. ʿAbd ar-Raḥmān al-Mizzī (d. 742/1341). Medieval commentaries as well as assorted biographical lexicons were drawn upon to illustrate the text of each tradition in all theological, social, legal and other noteworthy aspects discernible in it. Thus no details of eschatology, superstitions, miraculous phenomena, Jahili practices etc. were left without the clarifying comments of contemporary and later theologians, historians and ḥadīth experts culled from such works as the Fatḥ al-bārī, a major commentary of Bukhārī’s Ṣaḥīḥ by Ibn Ḥajar al-ʿAsqalānī (d. 852/1448) or the commentary by Yaḥya b. Sharaf an-Nawawī (d. 676/1277) of the Ṣaḥīḥ of Muslim b. al-Ḥajjāj. The encyclopedia concludes with an exhaustive index and glossary of names and concepts, which functions at the same time as a concordance. In short, this work presents an indispensable sourcebook of the development of Islam in all its facets during the first three centuries since its foundation as reflected in canonical ḥadīth.




Brussels Ibis Regulation


Book Description

This book focuses on major amendments introduced in the Brussels I regulatory framework. The contributions scrutenise the changes introduced in the Brussels Ibis Regulation, a legal instrument that presents a core of the unification of private international law rules on the European Union level. It is one of the first publications addressing all the changes in the Brussels I regulatory scheme, which takes into consideration relevant CJEU case law up to July 2016. The texts, written by legal scholars who have published extensively in the field of private international law and international civil procedure, will add to the development of EU private international law. In addition, the authors’ critical analysis may open further discussions on the topic and so benefit a consistent and harmonised application of the Regulation. In this respect the book takes a different approach than the commentaries which have so far been published. It is primarily meant for legal academics in private international law and practitioners who are regularly engaged in cross-border civil proceedings. It may also be of added value to advanced students and to those with a particular interest in the subject of international litigation and more generally in the area of dispute resolution. Vesna Lazić is a Senior Researcher at the T.M.C. Asser Instituut, an Associate Professor of Private Law at Utrecht University and Professor of European Civil Procedure at the University of Rijeka. Steven Stuij is an expert in Private International Law and an external Ph.D. candidate at Erasmus School of Law, Rotterdam.




Early Earth Systems


Book Description

Early Earth Systems provides a complete history of the Earth from its beginnings to the end of the Archaean. This journey through the Earth's early history begins with the Earth's origin, then examines the evolution of the mantle, the origin of the continental crust, the origin and evolution of the Earth's atmosphere and oceans, and ends with the origin of life. Looks at the evidence for the Earth's very early differentiation into core, mantle, crust, atmosphere and oceans and how this differentiation saw extreme interactions within the Earth system. Discusses Archaean Earth processes within the framework of the Earth System Science paradigm, providing a qualitative assessment of the principal reservoirs and fluxes in the early Earth. “The book would be perfect for a graduate-level or upper level undergraduate course on the early Earth. It will also serve as a great starting point for researchers in solid-Earth geochemistry who want to know more about the Earth’s early atmosphere and biosphere, and vice versa for low temperature geochemists who want to get a modern overview of the Earth’s interior.” Geological Magazine, 2008