Disorders of Sex Development


Book Description

The rapid advances in medicine over the last 50 years have totally changed the outlook for children with disorders of sex development (DSD), but there is still much to learn. This book crystallizes the combined experience of a leading dedicated unit over 25 years in delivering expert medical and surgical care to children with DSD in a holistic environment. It documents the most recent advances in the molecular biology and embryology of sex development, and describes each disorder in detail. The clinical presentation and approach to diagnosis are described both for babies and for children presenting later in childhood or at adolescence. The chapters on management highlight all the latest knowledge and include the shared wisdom of the authors on current controversies, such as the timing of surgical treatment. Finally, the authors describe their short-, medium-, and long-term outcomes, which demonstrate the strengths of holistic team management.




Exploring the Biological Contributions to Human Health


Book Description

It's obvious why only men develop prostate cancer and why only women get ovarian cancer. But it is not obvious why women are more likely to recover language ability after a stroke than men or why women are more apt to develop autoimmune diseases such as lupus. Sex differences in health throughout the lifespan have been documented. Exploring the Biological Contributions to Human Health begins to snap the pieces of the puzzle into place so that this knowledge can be used to improve health for both sexes. From behavior and cognition to metabolism and response to chemicals and infectious organisms, this book explores the health impact of sex (being male or female, according to reproductive organs and chromosomes) and gender (one's sense of self as male or female in society). Exploring the Biological Contributions to Human Health discusses basic biochemical differences in the cells of males and females and health variability between the sexes from conception throughout life. The book identifies key research needs and opportunities and addresses barriers to research. Exploring the Biological Contributions to Human Health will be important to health policy makers, basic, applied, and clinical researchers, educators, providers, and journalists-while being very accessible to interested lay readers.




Sex Differences in Physiology


Book Description

Sex Differences in Physiology is an all-encompassing reference that details basic science research into sex differences in all physiological fields. It includes scientific discoveries concerning sex differences in cardiovascular, respiratory, renal, gastrointestinal, and musculoskeletal physiology. In addition, coverage of the development, endocrinology, neurophysiology, immunity, and metabolism is included, making this important reference a resource that will meet the needs of investigators interested in incorporating sex differences into their research programs, while also providing clinicians with the basis for providing the best sex-based medical treatment options available. Provides a sweeping, organ-by-organ review of currently observed sex differences in animal models and human disease Explains how sex differences influence physiology and disease Provides the critical knowledge on sex differences for better understanding of prevention and treatment of diseases




The Cambridge Handbook of Sexual Development


Book Description

The Cambridge Handbook of Sexual Development is a carefully curated conversation that brings together the top researchers in child and adolescent sexual development to redefine the issues, conflicts, and debates in the field. The Handbook is organized around three foundational questions: first, what is sexual development? Second, how do we study sexual development? And third, what roles might adults - including the institutions of the media, family, and education - play in the sexual development of children and adolescents? As the first of its kind, this collection integrates work from sociology, psychology, anthropology, history, education, cultural studies, and allied fields. Writing from different disciplinary traditions and about a range of international contexts, the contributors explore the role of sexuality in children's and adolescents' everyday experiences of identity, family, school, neighborhood, religion, and popular media.




Genetic Steroid Disorders


Book Description

Genetic Steroid Disorders, Second Edition targets adult and pediatric endocrinologists, clinical geneticists, genetic counselors, reproductive endocrinologists, neonatologists, urologists, and psychoendocrinologists. It is designed to assist these specialists in the diagnosis and treatment of steroid disorders. This revision includes a new chapter on "Gonadotropins, Obesity and Bone" and new research on non-invasive prenatal diagnosis with cell-free DNA. Chapters are thoroughly updated covering steroid disorders, the genetic bases for the disorder and case presentations, This definitive reference belongs in every medical library! - Presents a comprehensive, translational look at all aspects of genetic steroid disorders in one reference work - Provides a common language for endocrinologists, geneticists, molecular pathologists, and genetic counselors to discuss and diagnose genetic steroid disorders Saves clinicians and researchers time in quickly accessing the very latest details on genetic tests and diagnoses as opposed to searching through thousands of journal articles - Highlights significant discoveries with clinical relevance, presenting insight into which medications to use based on the genetic makeup of a patient - Teaches the best strategies and most effective use of genetic information in the patient counseling setting




Disorders of Sex Development


Book Description

Compassionately written by an experienced team of professionals, this book offers parents and families essential information about the causes, diagnosis, and treatment of disorders of sex development, or DSD. DSD refers to medical conditions, usually discovered at birth, in which there is disagreement between a person's genetic sex (i.e., chromosomes) and the appearance of the person's external or internal reproductive structures. After their child is diagnosed with DSD, parents need answers to a host of questions, including ? What is DSD, why does it occur, how is it identified, and how is it treated?? Did we do something to cause our child's DSD?? Is my baby a boy or a girl?? Will my child grow up to be normal and healthy?? Does my child need surgery? This concise book answers parents' questions in a reassuring and forthright way, giving affected individuals, their families, and their health care providers a current and evidence-based picture of DSD. It offers clear explanations of how newborns with DSD are evaluated, diagnosed, and treated; describes the different kinds of DSD; and pays close attention to both psychosocial and medical aspects of DSD. This guide also includes information about the importance of support groups and education for affected individuals and their families. In their daily work, the authors treat, support, and educate people with DSD and their families. This resource gives parents and families access to the authors' expertise so they can reach a meaningful understanding of their child's DSD and make informed decisions about their child's health.




Textbook of Clinical Embryology


Book Description

The success of Assisted Reproductive Technology is critically dependent upon the use of well optimized protocols, based upon sound scientific reasoning, empirical observations and evidence of clinical efficacy. Recently, the treatment of infertility has experienced a revolution, with the routine adoption of increasingly specialized molecular biological techniques and advanced methods for the manipulation of gametes and embryos. This textbook – inspired by the postgraduate degree program at the University of Oxford – guides students through the multidisciplinary syllabus essential to ART laboratory practice, from basic culture techniques and micromanipulation to laboratory management and quality assurance, and from endocrinology to molecular biology and research methods. Written for all levels of IVF practitioners, reproductive biologists and technologists involved in human reproductive science, it can be used as a reference manual for all IVF labs and as a textbook by undergraduates, advanced students, scientists and professionals involved in gamete, embryo or stem cell biology.




The Biology of Reproduction


Book Description

A look into the phenomena of sex and reproduction in all organisms, taking an innovative, unified and comprehensive approach.




Introducing the New Sexuality Studies


Book Description

Previously published under title: New sexuality studies.




Brain Gender


Book Description

Do biological factors, such as gonadal hormones, determine our sexual destiny after our genes are in place? Do they make men aggressive, or women nurturing? Do they cause boys and girls to play differently or to have different interests? Do they explain differences in sexual orientation within each sex group? Do they contribute to the preponderance of men in science or women at home? Scientists working from a psychosocial perspective would answer these questions differently than those working from a behavioral neuroscience or neuroendocrinological perspective. This book brings both of these perspectives to bear on the questions, tracing the factors that influence the brain, beginning with testosterone and other hormones during prenatal life, and continuing through changing life situations and experiences that can sculpt the brain and its activity, even in adulthood. This influence has important implications for understanding the social roles of men and women in society, the different educational and emotional issues that confront males and females, the legal rights of those whose sexual orientation or gender identity do not correspond to norms, and even standards of clinical care for people born with physical intersex conditions that make it difficult to classify a person as male or female at birth. This original and accessible book will be of interest to psychologists, neuroscientists, pediatricians, and educators, as well as the general public. It is also suitable for use in graduate and undergraduate courses on the psychology of gender or on hormones and behavior.