Dynamics Of The Vascular System: Interaction With The Heart (Second Edition)


Book Description

The first edition of the book was written employing mathematical techniques to formulate the physical principles involved in the structural and functional correlates of the underlying physiology.This current and self-contained second edition updates many of the new findings since its first edition a decade ago. It also includes a new chapter on the 'Interaction with the Heart'. The dynamics of the arterial system, the venous system, the microcirculation and their interaction with the heart are quantitatively described in terms of their structures and functions. Clinical measurements, applications to the cardiovascular field and physiological mechanisms are clearly identified throughout the text. Most importantly, worked examples are provided, such that the readers can appreciate the application aspects of the underlying formulation.




Vascular Dynamics


Book Description

The function of the vascular system is to transport oxygen and nutrients to the cells and to remove carbon dioxide and metabolites. It also transports hormones and locally produced neurohumoral substances which, in part, regulate its own function. These interrelationships are essential to homeostasis. The vascular system is not an assembly of simple (elastic) tubes but a dynamic system with many external and intrinsic regulatory mechanisms. The endothelium plays a major role in the intrinsic regulation of the system. The system is also often subject to disease processes of which atherosclerosis is the most important. As a result of atherosclerosis, and other disease processes, replacement of vessels with prosthetic devices may be required to reestablish adequate tissue blood flow. It is therefore imperative to gain insight into the details of vascular function, especially the dynamics, and the endothelium, the processes of atherosclerosis development, the vascular prosthetic possibilities and, last but not least, the interrelationships between these sub-specialties.




Cardiovascular Fluid Dynamics


Book Description

Cardiovascular Fluid Dynamics, Volume 1 explores some problems and concepts of mammalian cardiovascular function, with emphasis on experimental studies and methods. It considers pressure measurement in experimental physiology, including the measurements of pulsatile flow, flow velocity, lengths, and dimensions; the use of control theory and systems analysis in cardiovascular dynamics; the application of computer models in cardiovascular research; the meaning and measurement of myocardial contractility; and the consequences of the steady-state analysis of arterial function. Organized into 10 chapters, this volume begins with an overview of the mammalian cardiovascular system and the essential features of cardiovascular function. It then discusses the practical problems associated with the use of pressure transducers in physiological and cardiac laboratories, the challenges involved in pulsatile flow measurement using flowmeters and thermal devices, and the mechanical analysis of the circulatory system. It explains some computer modeling techniques used in investigating the hemodynamics of the cardiovascular system, including the heart and heart muscle; basic concepts of muscle mechanics and the mechanical properties of cardiac muscle; the fluid mechanics of heart valves; and the pressure and flow in large arteries. The book concludes with a chapter on vascular resistance and vascular input impedance. This book is intended for biologists, physical scientists, and others interested in cardiovascular physiology.




Cardiovascular Fluid Dynamics


Book Description

First Published in 1981, this book offers a full, comprehensive guide to the operation of cardiovascular fluid systems. Carefully compiled and filled with a vast repertoire of notes, diagrams, and references this book serves as a useful reference for cardiologists, haematologists, students of medicine, and other practitioners in their respective fields.




Mechanisms of Vascular Disease


Book Description

New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.




Circulatory System Dynamics


Book Description

Circulatory System Dynamics reviews cardiovascular dynamics from the analytical viewpoint and indicates ways in which the accumulated knowledge can be expanded and applied to further enhance understanding of the normal mammalian circulation, to ascertain the nature of difficulties associated with disease, and to test the effect of treatment. Comprised of 10 chapters, this volume begins with an overview of the circulatory system, including its anatomy and the trigger for myocardial (heart muscle) contraction. The discussion then turns to measurement of blood pressure using invasive and non-invasive techniques; blood flow measurement, with emphasis on cardiac output and measurement in the microcirculation; the system and pulmonary arterial trees; and pulsatile pressure and flow in pulmonary veins. Subsequent chapters explore microcirculation and the anatomy of the microvasculature; the heart and coronary circulation, paying particular attention to the Frank-Starling mechanism and indices of myocardial "contractility"; and control of blood pressure, peripheral resistance, and cerebral flow. The last two chapters deal with circulatory assistance and the closed cardiovascular system. This book will be of interest to students, practitioners, and researchers in fields ranging from physiology and biology to biochemistry and biophysics.




Multiscale Modeling of Vascular Dynamics of Micro- and Nano-particles


Book Description

Recent advances witness the potential to employ nanomedicine and game-changing methods to deliver drug molecules directly to diseased sites. To optimize and then enhance the efficacy and specificity, the control and guidance of drug carriers in vasculature has become crucial. Current bottlenecks in the optimal design of drug carrying particles are the lack of knowledge about the transport of particles, adhesion on endothelium wall and subsequent internalization into diseased cells. To study the transport and adhesion of particle in vasculature, the authors have made great efforts to numerically investigate the dynamic and adhesive motions of particles in the blood flow. This book discusses the recent achievements from the establishment of fundamental physical problem to development of multiscale model, and finally large scale simulations for understanding transport of particle-based drug carriers in blood flow.




Mechanisms of Vascular Disease


Book Description

This extensively revised third edition provides a practically applicable guide to the pathophysiology, assessment and management of vascular disorders encountered in vascular surgical practice. It features detailed information on the latest developments in the pathophysiology of conditions including atherosclerosis, multi-organ failure, limb compartment syndromes and Raynaud’s phenomenon in a clear easy to digest format. Disorders such as reperfusion injuries, vasculitides, and aortic dissection are covered. Furthermore, key topics in vascular and endovascular practice such as radiation biology and radiation safety are also detailed. Each chapter contains a set of learning objectives and key references, enabling the reader to quickly identify key points. Mechanisms of Vascular Disease: A Textbook for Vascular Specialists comprehensively covers a variety of common and unusual pathophysiologies encountered in vascular surgery, and is an ideal resource for both the trainee, and practicing clinical vascular surgeon seeking an up-to-date resource on the topic.




Regulation of Coronary Blood Flow


Book Description

Research centering on blood flow in the heart continues to hold an important position, especially since a better understanding of the subject may help reduce the incidence of coronary arterial disease and heart attacks. This book summarizes recent advances in the field; it is the product of fruitful cooperation among international scientists who met in Japan in May, 1990 to discuss the regulation of coronary blood flow.




Arteriovenous Access Surgery


Book Description

This book offers a comprehensive overview of up-to-date knowledge on vascular access surgery. Written by a senior author with more than 30 years of experience and by expert contributors, it covers both surgical and theoretical aspects. The author shares his expertise in a hands-on approach and presents his views on the difficulties that every clinician may encounter. The various options for vascular access creation are carefully reviewed. Detailed descriptions and numerous accompanying illustrations of AV fistulas, AV prosthetic grafts, and arterio arterial grafts are provided, and a chapter is also devoted to the use of central venous catheters. Potential complications and their management are explained, and advice is offered on how to deal with special patient groups requiring extra attention. Separate chapters on fluid dynamics (drawing on the author’s own research) and vascular pathology cater for the needs of those with a particular interest in the pathophysiological principles.