Visualization of Receptors


Book Description

A multiplicity of methods for visualization are described in Visualization of Receptors. This book of techniques covers immunocytology, radioautography, in situ hybridization, plasmon resonance, RT in vitro PCR, and X-ray crystal structure analysis. Lecturers, researchers, practitioners, technicians, and students will find all the principles and protocols they require and the means of implementing them. Topics discussed include localization of ligands (in vitro or in vivo), visualization of immunoreactivities of ligand and receptor proteins, detection and quantification of mRNA expression, amplification of signals, and determination of 3-D structure. Details of protocols with illustrations of results and commentaries are provided throughout the book.




Visualization of Receptors In Situ


Book Description

Radioligand binding in situ is the most sensitive method for detecting available receptors; the success and reliability of this approach are determined by a number of technical requirements and constraints. Based on the authors' fifteen years of experience in the field, Visualization of Receptors In Situ: Applications of Radioligand Binding explici




Receptors


Book Description

Receptors: Models for Binding, Trafficking, and Signaling bridges the gap between chemical engineering and cell biology by lucidly and practically demonstrating how a mathematical modeling approach combined with quantitative experiments can provide enhanced understanding of cell phenomena involving receptor/ligand interactions. In stressing the need for a quantitative understanding of how receptor-mediated cell functions depend on receptor and ligand properties, the book offers comprehensive treatments of both basic and state-of-the-art model frameworks that span the entire spectrum of receptor processes--from fundamental cell surface binding, intracellular trafficking, and signal transduction events to the cell behavioral functions they govern, including proliferation, adhesion, and migration. The book emphasizes mechanistic models that are accessible to experimental testing and includes detailed examples of important contemporary issues. This much-needed book introduces chemical engineers and bioengineers to important problems in receptor biology and familiarizes cell biologists with the insights that can be gained from engineering analysis and synthesis. As such, chemical engineers, researchers, and advanced students in the fields of biotechnology, biomedical sciences, bioengineering, and molecular cell biology will find this book to be conceptually rich, timely, and useful.




5-HT2C Receptors in the Pathophysiology of CNS Disease


Book Description

Part of Springer’s “The Receptors,” series, this text is the first ever overview on the research of 5-HT2c receptors. 5-HT2c receptor research has been productive for twenty-five years, but recent years have seen an extraordinary increase in both amount produced and insight gained. 5-HT2c is a prominent central serotonin receptor subtype widely expressed within the central and the peripheral nervous system and is thought to play a key role in the regulation of numerous behaviors. This text covers the molecular, cellular, anatomical, biochemical and behavioral aspects of this receptor, highlighting its distinctive regulatory properties and the emerging functional significance of constitutive activity and RNA-editing in vivo. It also investigates the receptors’ therapeutic potential in many diseases, treated individually in separate chapters, including depression, drug abuse, schizophrenia, eating disorders, Parkinson’s disease, Prader-Willi Syndrome, Alzheimer’s disease and epilepsy.




Regulatory Peptides


Book Description

J. M. Polak and S. R. Bloom For some time Experientia has published, as a unique feature, interdis ciplinary multi-author reviews, giving a comprehensive overview of sub jects regarded as 'growing edges' of science. The enthusiasm shown by the readers was contagious and thus it was felt necessary to compile a special volume dealing with the novel aspects of regulatory peptides. This book covers some of the growing areas in regulatory peptide research and, although it is based on the original volume of Experientia, it is expanded and updated. The topic of 'regulatory peptides' is relatively young and has grown at an unprecedented pace, from the embryonic conception of 'gut hor mones' or 'brain neuropeptides' some 15 years ago to the realisation that these active pep tides are found, almost without exception, in every part of l8 23 the body in all vertebrate and many invertebrate species • Why the term 'regulatory peptides'? It represents a convenient label encompassing both the active peptides present in nerves, which are re leased as (putative) neurotransmitters, and those in endocrine cells, which act locally or at a distance as circulating hormones, these being the l8 main components of the so-called diffuse neuroendocrine or APUD 17 system • Morphological studies support this physiological viewpoint.




Multidimensional Data Visualization


Book Description

This book highlights recent developments in multidimensional data visualization, presenting both new methods and modifications on classic techniques. Throughout the book, various applications of multidimensional data visualization are presented including its uses in social sciences (economy, education, politics, psychology), environmetrics, and medicine (ophthalmology, sport medicine, pharmacology, sleep medicine). The book provides recent research results in optimization-based visualization. Evolutionary algorithms and a two-level optimization method, based on combinatorial optimization and quadratic programming, are analyzed in detail. The performance of these algorithms and the development of parallel versions are discussed. The utilization of new visualization techniques to improve the capabilies of artificial neural networks (self-organizing maps, feed-forward networks) is also discussed. The book includes over 100 detailed images presenting examples of the many different visualization techniques that the book presents. This book is intended for scientists and researchers in any field of study where complex and multidimensional data must be represented visually.




Software Visualization


Book Description

Here is an ideal textbook on software visualization, written especially for students and teachers in computer science. It provides a broad and systematic overview of the area including many pointers to tools available today. Topics covered include static program visualization, algorithm animation, visual debugging, as well as the visualization of the evolution of software. The author's presentation emphasizes common principles and provides different examples mostly taken from seminal work. In addition, each chapter is followed by a list of exercises including both pen-and-paper exercises as well as programming tasks.




Radionuclide Imaging of the Breast


Book Description

Demonstrating the role of nuclear medicine as a complementary technique to mammography and other imaging modalities for the diagnosis of breast cancer, Radionuclide Imaging of the Breast provides a comprehensive overview of scintimammography-an accurate, safe, and noninvasive imaging method for the evaluation of breast lesions and malignancies. Reveals the encouraging results of multicenter clinical trials in the U.S. and Canada using 99mTc sestamibi breast imaging for the diagnosis of primary breast carcinoma! Addressing nonsurgical sampling of nonpalpable breast lesions as an effective means of providing diagnostic and prognostic information, Radionuclide Imaging of the Breast discusses increasing the diagnostic value of mammography and its widespread use examines the reliability of FDG-PET and FDG-SPECT in detecting lymph node involvement and distant metastases reviews breast cancer imaging with monoclonal antibodies, including murine and bioengineered antibodies compares the benefits and limitations of Thallium-20l to 99mTc-sestamibi breast imaging in evaluating suspected malignancy assesses the clinical impact of scintimammography as an adjunctive test to mammography to improve the dependability of diagnoses considers the possibility of replacing axillary lymph node dissection in patients with small breast cancers with the sentinel node approach clarifies the importance of surgery in the multimodality treatment of breast cancer elucidates pathologic difficulties for breast cancer diagnosis and more! Radionuclide Imaging of the Breast serves as an essential reference for nuclear medicine physicians, radiologists, breast surgeons, medical and surgical oncologists, gynecologists, pathologists, internists, and primary care physicians.




Information Visualization


Book Description

"This is a book about what the science of perception can tell us about visualization. There is a gold mine of information about how we see to be found in more than a century of work by vision researchers. The purpose of this book is to extract from that large body of research literature those design principles that apply to displaying information effectively"--




Perceptions of Knowledge Visualization: Explaining Concepts through Meaningful Images


Book Description

Multisensory perception is emerging as an important factor in shaping current lifestyles. Therefore, computer scientists, engineers, and technology experts are acknowledging the comparative power existing beyond visual explanations. Perceptions of Knowledge Visualization: Explaining Concepts through Meaningful Images discusses issues related to visualization of scientific concepts, picturing processes and products, as well as the role of computing in the advancement of visual literacy skills. By connecting theory with practice, this book gives researchers, computer scientists, and academics an active experience which enhances the perception and the role of computer graphics.