Walter Gilbert


Book Description




Walter Gilbert


Book Description

This book commemorates the eclectic intellectual life of scientist and artist Walter Gilbert. It presents all of his most influential works throughout his scientific career. His scientific explorations covered a broad spectrum of fields: theoretical physics; molecular biology, from finding messenger RNA to elucidating the regulation of the lac operon to understanding DNA replication; gene evolution and origin of life; genomics; bioinformatics; and beyond. He created widely used concepts such as "Exon", "Intron" and "RNA World". Eleven reflective essays by Gilbert are included for the first time, discussing both his scientific studies and anecdotes from his own life. These firsthand accounts record the historical and intellectual contexts for his most monumental scientific discoveries, including his Nobel Prize-winning sequencing method. Memorial chapters, contributed by Gilbert Laboratory alumni, describe the passion, ambition, and efforts of Gilbert and several generations of young scientists under his leadership. Finally, the book collects a few fine pieces of artwork created by Gilbert in recent years. It documents a life of genius and creativity that could inspire others for years to come.




The Practices of Human Genetics


Book Description

That concern about human genetics is at the top of many lists of issues requiring intense discussion from scientific, political, social, and ethical points of view is today no surprise. It was in the spirit of attempting to establish the basis for intelligent discussion of the issues involved that a group of us gathered at a meeting of the International Society for the History, Philosophy, and Social Studies of Biology in the Summer of 1995 at Brandeis University and began an exploration of these questions in earlier versions of the papers presented here. Our aim was to cross disciplines and jump national boundaries, to be catholic in the methods and approaches taken, and to bring before readers interested in the emerging issues of human genetics well-reasoned, informative, and provocative papers. The initial conference and elements of the editorial work which have followed were generously supported by the Stifterverband fUr die Deutsche Wissenschaft. We thank Professor Peter Weingart of Bielefeld University for his assistance in gaining this support. As Editors, we thank the anonymous readers who commented upon and critiqued many of the papers and in tum made each paper a more valuable contribution. We also thank the authors for their understanding and patience. Michael Fortnn Everett Mendelsohn Cambridge, MA September 1998 vii INTRODUCTION In 1986, the annual symposium at the venerable Cold Spring Harbor laboratories was devoted to the "Molecular Biology of Homo sapiens.







Wavelets and Other Orthogonal Systems, Second Edition


Book Description

A bestseller in its first edition, Wavelets and Other Orthogonal Systems: Second Edition has been fully updated to reflect the recent growth and development of this field, especially in the area of multiwavelets. The authors have incorporated more examples and numerous illustrations to help clarify concepts. They have also added a considerable amount of new material, including sections addressing impulse trains, an alternate approach to periodic wavelets, and positive wavelet s. Other new discussions include irregular sampling in wavelet subspaces, hybrid wavelet sampling, interpolating multiwavelets, and several new statistics topics. With cutting-edge applications in data compression, image analysis, numerical analysis, and acoustics wavelets remain at the forefront of current research. Wavelets and Other Orthogonal Systems maintains its mathematical perspective in presenting wavelets in the same setting as other orthogonal systems, thus allowing their advantages and disadvantages to be seen more directly. Now even more student friendly, the second edition forms an outstanding text not only for graduate students in mathematics, but also for those interested in scientific and engineering applications.







Candid Science Ii: Conversations With Famous Biomedical Scientists


Book Description

This invaluable book contains 36 interviews, including 26 with Nobel laureates. It presents a cross-section of biomedical science, a field that has been dominant in science for the past half century. The in-depth conversations cover important research areas and discoveries, as well as the roads to these discoveries, including aspects of the scientists' work that never saw publication. They also bring out the humanness of the famous scientists — the reader learns about their backgrounds, aspirations, failings, and triumphs. The book is illustrated with snapshots of the conversations and photos provided by the interviewees. It is a follow-up to the critically acclaimed Candid Science: Conversations with Famous Chemists, by the same author./a




Drawing the Map of Life


Book Description

Drawing the Map of Life is the dramatic story of the Human Genome Project from its origins, through the race to order the 3 billion subunits of DNA, to the surprises emerging as scientists seek to exploit the molecule of heredity. It's the first account to deal in depth with the intellectual roots of the project, the motivations that drove it, and the hype that often masked genuine triumphs. Distinguished science journalist Victor McElheny offers vivid, insightful profiles of key people, such as David Botstein, Eric Lander, Francis Collins, James Watson, Michael Hunkapiller, and Craig Venter. McElheny also shows that the Human Genome Project is a striking example of how new techniques (such as restriction enzymes and sequencing methods) often arrive first, shaping the questions scientists then ask. Drawing on years of original interviews and reporting in the inner circles of biological science, Drawing the Map of Life is the definitive, up-to-date story of today's greatest scientific quest. No one who wishes to understand genome mapping and how it is transforming our lives can afford to miss this book.




Biotechnology 101


Book Description

What should the average person know about science? Because science is so central to life in the 21st century, science educators and other leaders of the scientific community believe that it is essential that everyone understand the basic concepts of the most vital and far-reaching disciplines. Biotechnology 101 does exactly that. This accessible volume provides readers - whether students new to the field or just interested members of the lay public - with the essential ideas of biotechnology using a minimum of jargon and mathematics. Concepts are introduced in a progressive order so that more complicated ideas build on simpler ones, and each is discussed in small, bite-sized segments so that they can be more easily understood. This short volume will enable students and lay people to understand the basics of one of the most important scientific fields of endeavor for the future.




The Big Idea


Book Description

From the Pythagorean theorem to DNA's double helix, from the discovery of microscopic life-forms to the theory of relativity--the big ideas of science and technology shape an era's worldview. Open this book, grasp the newest ideas from thought leaders of today, then spring off from them to move back through the past, one big idea at a time. Meet the people who gave birth to these ideas--and those who fought against them. Meet the MIT electrical engineer currently developing a way to turn on the lights cordlessly, then move back through Nikola Tesla's visionary concept of the wireless transfer of energy, Thomas Edison's groundbreaking work in developing a nationwide electrical grid, Ben Franklin's experiments to capture electricity, all the way back to ancient Greece, where Thales of Miletus described static electricity as a property of naturally occurring amber. Ingeniously organized and eminently browsable, this richly visual volume is divided into six big sections--medicine, transportation, communication, biology, chemistry, and the environment. Words and images that work together to explain such fascinating and elusive subjects as cloud computing, sunshields to cool the Earth, and self-driving cars. What did it take to get to these futuristic realities? Then, turn the page and follow a reverse-chronological illustrated time line of science and technology. This remarkable illustrated history tells the story of every Big Idea in our history, seen through the lens of where science is taking us today - and tomorrow. With an irresistibly cutting-edge look and original illustrations created by award-winning Ashby Design, paired with the reliable authority and comprehensiveness that National Geographic's world history books always offer, this is a one-of-a-kind trip to the future and back through all time all in one.