Werner’s Syndrome and Human Aging


Book Description










Molecular Mechanisms of Werner’s Syndrome


Book Description

During our short time on earth, we all undergo the highly complex process of aging, and with it, we experience the many physiological symptoms. Studies of premature aging have produced a great deal of information that gives some aspects of aging a better understanding. This book explores Werner's syndrome. To some, Werner's syndrome is considered a caricature of aging, but others will find it fascinating that only one mutated human gene (WRN) can bring about a multitude of complicated phenotypes that are usually associated with aging.




Time of Our Lives


Book Description

By the year 2050 one in five of the world's population will be 65 or older, a fact which presages profound medical, biological, philosophical, and political changes in the coming century. In Time of Our Lives, Tom Kirkwood draws on more than twenty years of research to make sense of the evolution of aging, to explain how aging occurs, and to answer fundamental questions like why women live longer than men. He shows that we age because our genes, evolving at a time when life was "nasty, brutish, and short," placed little priority on the long-term maintenance of our bodies. With such knowledge, along with new insights from genome research, we can devise ways to target the root causes of aging and of age-related diseases such as Alzheimer's and osteoporosis. He even considers the possibility that human beings will someday have greatly extended life spans or even be free from senescence altogether. Beautifully written by one of the world's pioneering researchers into the science of aging, Time of Our Lives is a clear, original and, above all, inspiring investigation of a process all of us experience but few of us understand.




Our Future Selves


Book Description

The goal of biomedical research on aging is to prolong the useful and active lives of the elderly and to raise the quality of their lives. That can be accomplished if we understand the normal process of aging, the nature of diseases common to the aged, and the sources of and remedies for many of the painful disabilities suffered by the aged. The major systems within the body fail at different rates, depending upon the inherited characteristics and environmental experiences of the individual. One goal of biomedical research is to characterize, for the various organ systems of the body, the progressive loss of functions with age. Biomedical research on aging can be divided into three major areas: basic biological aspects of aging, the interaction of aging and disease, and the interaction of external, or environmental, influences and aging. Important elements in research on aging include: experimental model systems, the study of human populations, studies of alteration of life span, and resources and training needs.




Biology of Aging


Book Description

The survival of the human species has improved significantly in modern times. During the last century, the mean survival of human populations in developed countries has increased more than during the preceding 5000 years. This improvement in survival was accompanied by an increase in the number of active years. In other words, the increase in mean life span was accompanied by an increase in health span. This is now accentuated by progress in medicine reducing the impact of physiologic events such as menopause and of patho logical processes such as atherosclerosis. Up to now,research on aging, whether theoretical or experimental, has not contributed to improvement in human survival. Actually, there is a striking contrast between these significant modifications in survival and the present knowledge of the mechanisms of human aging. Revealed by this state of affairs are the profound disagreements between gerontologists in regard to the way oflooking at the aging process. The definition of aging itself is difficult to begin with because of the variability of how it occurs in different organisms.




Challenging Cases in Dermatology


Book Description

The cases presented in this book will guide the reader through the process of making a diagnosis based on logical thinking. The book provides a wealth of knowledge regarding diagnostic approaches and pearls of wisdom. In addition to unusual presentations of common diseases, it includes discussions about rare diseases, complex cases, surprising diagnoses, therapeutic challenges and other important features. Becoming acquainted with such unusual cases will provide the dermatologist with increased knowledge, a wider perspective, and innovative techniques that can be used to solve diagnostic dilemmas. Readers will improve their way of thinking and data analysis, and will be able to improve differential diagnoses. This book provides the unique feature of a strategic way of thinking while discussing each case, in order to reach a diagnosis. The text includes comparisons of each case to other similar cases, pointing out the distinguishing features of conditions under consideration.




Aging


Book Description

Why do people age differently? Research in the field of gerontology has indicated that there are large individual differences in personality, cognitive functioning, physical health, and psychological well-being, as well as in the quality of life in the later years. It is this variability and the reasons why people age differently that this book explores. Thoughtfully written, Aging presents an overview of what is known about genetic and environmental influences on aging. Beginning with an overview of family, adoption, and twin designs, author Cindy S. Bergeman examines such topics as the research in the area of longevity and health, cognitive functioning, personality, and psychopathology; and social support, life events, and measures of the family environment. The book concludes with a summary of the field of gerontological behavioral genetics. This book will stimulate discussion and future work about the origins of individual differences in later life and will be invaluable to professionals and practitioners in the fields of developmental psychology, psychology, aging, family studies, and nursing.




Handbook of Models for Human Aging


Book Description

The Handbook of Models for Human Aging is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion of model availability, key methods, and ethical issues. - Utilizes a multidisciplinary approach - Shows tricks and approaches not available in primary publications - First volume of its kind to combine both methods of study for human aging and animal models - Over 200 illustrations