With the Eyes on Non-Coding RNAs
Author : Ivan Conte
Publisher : Frontiers Media SA
Page : 175 pages
File Size : 18,51 MB
Release : 2021-09-28
Category : Science
ISBN : 2889713997
Emerging Roles of Long Noncoding RNAs in Neurological Diseases and Metabolic Disorders
Author : Yingqun Huang
Publisher : Frontiers Media SA
Page : 78 pages
File Size : 32,73 MB
Release : 2015-07-21
Category : Biology (General)
ISBN : 2889195716
Book Description
Long noncoding RNAs (lncRNAs) are a new class of transcripts that are in general longer than 200 nucleotides and that have no protein-coding potential. The vast majority of vertebrate genomes encode diverse and complex lncRNAs that play regulatory roles at almost every step of gene expression. Recently, increasing evidence has implicated lncRNAs in the pathogenesis of various human diseases. The purpose of the Research Topic, "Emerging roles of long noncoding RNAs in neurological diseases and metabolic disorders", is to bring together leading researchers in the field who, through contributing to an organized and comprehensive collection of peer-reviewed articles, provide a broad perspective on the latest advances in the field. A number of interesting and cutting-edge areas will be covered as below, but this list is not exclusive: - The methodologies and technologies of identifying and studying lncRNAs - LncRNAs in gene-specific transcription - LncRNAs in epigenetic regulation - LncRNAs in post-transcriptional regulation - LncRNAs in disease - Mapping of noncoding single nucleotide polymorphisms associated with disease.
Genetic Analysis
Author : Philip Meneely
Publisher :
Page : 491 pages
File Size : 27,70 MB
Release : 2020
Category : Medical
ISBN : 0198809905
Book Description
Genetic Analysis applies the combined power of molecular biology, genetics, and genomics to explore how the principles of genetics can be used as analytical tools to solve biological problems. This new edition: Illustrates the conceptual basis of key analytical tools with carefully selected examples from a range of model organisms, and encourages the reader to Look beyond the examples to see how these tools can be used to explore a wide range of biological questions, Covers the latest and most powerful experimental tools to provide a state-of-the-art review of the field, giving insights into gene networks and interactions, Includes extended case studies that enable the reader to fully get to grips with how genetic tools can be used to understand biological systems in the real world. New to This Edition: A new chapter on genome editing with focus on the CRISPR-Cas 9 system, New content on the analysis of gene activity using temperature-sensitive mutations and mosaics, Increased coverage of epigenetics, updated with the latest developments in the field, A new Learning feature called "Literature Link," which connects each chapter's content to cutting-edge research. The online resources to accompany Genetic Analysis feature the following material for students and teachers: For students: Practice problems and solutions to test your knowledge of the concepts presented, and help you to master them, Online datasets with which to practise analytic techniques, For registered adopters of the book: Figures from the book in electronic format, ready to download, Journal clubs-suggested papers and discussion questions linked to topics covered in the book. Book jacket.
Nuclear Structure and Gene Expression
Author : R. Curtis Bird
Publisher : Elsevier
Page : 317 pages
File Size : 35,92 MB
Release : 1996-11-28
Category : Science
ISBN : 0080537812
Book Description
Nuclear Structure and Gene Expression assimilates the contributions of genome organization and of the components of the nuclear matrix to the control of DNA and RNA synthesis. Nuclear domains which accommodate DNA replication and gene expression are considered in relation to short-term developmental and homeostatic requirements as well as to long-term commitments to phenotypic gene expression in differentiated cells. Consideration is given to the involvement of nuclear structure in gene localization as well as to the targeting and concentration of transcription factors. Aberrations in nuclear architecture associated with and potentially functionally related to pathologies are evaluated. Tumor cells are described from the perspective of the striking modifications in both the composition and organization of nuclear components. Nuclear Structure and Gene Expression presents concepts as well as experimental approaches, which define functionality of nuclear morphology.* Mechanisms of interaction between nuclear structure and genes* Gene expression regulation by elements of the nuclear matrix* How nuclear structure exerts a regulatory effect on other aspects of cell function/physiology
Flesh Becomes Words
Author : Mark Springer
Publisher : Page Publishing Inc
Page : 251 pages
File Size : 28,9 MB
Release : 2023-02-23
Category : Fiction
ISBN :
Book Description
In science, not God we trust is the future America in which Jordan McCarty, a professor of seventeenth-century English literature, has just lost his job and is losing his eighteen-year-old son, Brenton, to a "God gang" as belief in the Bible is now against the law. Blessed with a photographic memory but in need of a job, Jordan joins the world of biotechnology kingpin and former colleague Dr. Richard Dickson, who offers him a position as a technology writer at his new life span extension company, BioSpan. After discovering how DNA preserves our thoughts and memories, Dr. Dickson partners with a Las Vegas titan, Armando Bigolosi, and a modern-day biohacker, Daulton Hayes, who has invented a technology capable of translating the genetic language of DNA into the English language, thereby turning flesh into words. With unlimited funding, these three men join forces and aim to apply this technology to translate the written words of great writers of the past into the DNA of their thoughts. They embark on an audacious plan to restore the minds of these writers, bring their souls back to life, and usher in the age of edutainment in Las Vegas. Having memorized the entire contents of the Bible to understand what has led his son astray from science, Jordan develops a belief in God, leading to a climatic confrontation with Dr. Dickson, when Dickson announces that he has translated the entire contents of the Bible into DNA and plans to replace his thoughts with God's thoughts.
Insights in Statistical Genetics and Methodology: 2022
Author : Simon Charles Heath
Publisher : Frontiers Media SA
Page : 172 pages
File Size : 46,84 MB
Release : 2023-10-24
Category : Science
ISBN : 283253645X
Book Description
This Research Topic is part of the Insights in Frontiers in Genetics series.
MicroRNA in Regenerative Medicine
Author : Chandan K. Sen
Publisher : Elsevier
Page : 1305 pages
File Size : 10,61 MB
Release : 2014-11-26
Category : Science
ISBN : 0124058582
Book Description
This work encapsulates the uses of miRNA across stem cells, developmental biology, tissue injury and tissue regeneration. In particular contributors provide focused coverage of methodologies, intervention and tissue engineering. Regulating virtually all biological processes, the genome's 1048 encoded microRNAs appear to hold considerable promise for the potential repair and regeneration of tissues and organs in future therapies. In this work, 50 experts address key topics of this fast-emerging field. Concisely summarizing and evaluating key findings emerging from fundamental research into translational application, they point to the current and future significance of clinical research in the miRNA area. Coverage encompasses all major aspects of fundamental stem cell and developmental biology, including the uses of miRNA across repair and regeneration, and special coverage of methodologies and interventions as they point towards organ and tissue engineering - Multi-colour text layout with 150 colour figures to illustrate important findings - Take home messages encapsulate key lessons throughout text - Short chapters offer focused discussion and clear 'voice'
Epigenetics in Human Disease
Author : Trygve O Tollefsbol
Publisher : Elsevier
Page : 1362 pages
File Size : 49,86 MB
Release : 2023-10-09
Category : Medical
ISBN : 0443218129
Book Description
Epigenetics in Human Disease, Third Edition examines the diseases and conditions on which we have advanced knowledge of epigenetic mechanisms, such as cancer, autoimmune disorders, aging, metabolic disorders, neurobiological disorders and cardiovascular disease. From molecular mechanisms and epigenetic technology to clinical translation of recent research, the nature and applications of the science is presented for those with interests ranging from the fundamental basis of epigenetics to therapeutic interventions for epigenetic-based disorders, with an emphasis throughout on understanding and application of key concepts in new research and clinical practice. Fully revised and up-to-date, this Third Edition discusses topics of current interest in epigenetic disease research, including stem cell epigenetic therapy, bioinformatic analysis of NGS data, epigenetic mechanisms of imprinting disorders, microRNA in cancer, epigenetic approaches to control obesity, epigenetics and airway disease, and epigenetics in cardiovascular disease. Further sections explore online epigenetic tools and datasets; early-life programming of epigenetics in age-related diseases; the epigenetics of addiction and suicide, and epigenetic approaches to regulating and preventing diabetes, cardiac disease, allergic disorders, Alzheimer's disease, respiratory diseases, and many other human maladies. In addition, each chapter now includes chapter summaries, definitions, and vibrant imagery and figures to reinforce understanding, as well as step-by-step methods and disease research case studies. - Includes contributions from leading international investigators involved in translational epigenetic research and therapeutic applications - Integrates methods and applications with fundamental chapters on epigenetics in human disease, along with an evaluation of recent clinical breakthroughs - Presents side-by-side coverage of the basis of epigenetic diseases and treatment pathways - Each chapter updated to include summaries, definitions, and vibrant imagery and figures to reinforce understanding - Features step-by-step methods and disease research case studies to put book concepts into practice
Molecular Geometry of Body Pattern in Birds
Author : Antonio Lima-de-Faria
Publisher : Springer Science & Business Media
Page : 171 pages
File Size : 10,86 MB
Release : 2012-03-19
Category : Science
ISBN : 3642253016
Book Description
After having read this book you will never see birds in the same way again. The unexpected patterns displayed by a bird’s body have been seen as bizarre events that demanded little attention or were described as ‘amazing curiosities’. None of these surprising features seem to be fortuitous. They appear to be an integral part of a rigid order and a coherent geometry, which is directed by simple gene interactions and molecular cascades occurring at various cellular levels, and at different times, during the organism’s development. A novel geometry unfolds in front of your eyes, giving the body configurations another meaning. Lima-de-Faria is Professor Emeritus of Molecular Cytogenetics at Lund University, Lund, Sweden. This is his sixth book dealing with the molecular organization of the chromosome and its implications for the understanding of the mechanisms responsible for biological evolution.
Epigenetics Traits in Mammalian Tissues. From New Technology to New Hypotheses
Author : Michael E. Symonds
Publisher : Frontiers Media SA
Page : 70 pages
File Size : 28,89 MB
Release : 2019-09-23
Category :
ISBN : 2889630374
Book Description
How with the same genome a neuron is so different from a muscle cell? In Eva Jablonka and Lamb’s words, "epigenetics is one of the four dimensions of evolution". Actually, epigenetics should anything which occur in living cells that cannot be only explained by the genes/genome. After decades thinking and acting as if the genome determined the absolute fate of any life form in Earth, the relevance of epigenetics for mammalian life, disease and death is now recognized. In fact, assuming similar genomes, lifespan, lifestyle, and risk of diseases, etc. results from a balance between genes and epigenetic traits. The Research Topic aimed to show the differences of epigenetic traits between tissues, their physiological relevance and potential to target epigenetic mechanisms in human diseases.
