World Clinics: Dermatology: Psoriasis


Book Description

World Clinics - Dermatology: Psoriasis, Volume 2, Number 1 is the latest issue in the World Clinics – Dermatology series. The book provides information on therapeutic options for psoriasis. Divided into fourteen chapters, this book begins with epidemiology and discussion on the biology and pathology of psoriasis. Subsequent chapters cover topics including psoriasis in children, quality of life for psoriasis sufferers, nail and hair in psoriasis, and a review of current treatment options. Important treatment options such as phototherapy, topical therapy, and rotational and combination therapy have been covered in separate chapters. Biological therapies are also included, offering insight into future therapeutic options for psoriasis. With full colour images and illustrations throughout, and extensive information on current treatment, this volume of World Clinics – Dermatology: Psoriasis is an essential update for dermatologists. Key Points Discussion on current developments in the treatment of psoriasis Latest issue in the World Clinics – Dermatology series Series also includes volumes on Acne Colour images and illustrations throughout




Management of Psoriasis


Book Description

Treatments for psoriasis, besides affecting the skin, may be associated with various comorbidities (for instance, depression, psoriatic arthritis, Crohn's disease and, in severe psoriasis, metabolic syndrome and cardiovascular diseases), which often presents a therapeutic challenge to physicians.Written by renowned experts, this volume gives a comprehensive overview of psoriasis and its various comorbidities. It describes the treatment modalities for mild and moderate-to-severe psoriasis, including topical, phototherapeutic and conventional systemic treatments (e.g. acitretine, methotrexate and cyclosporine), as well as biological therapies (e.g. alefacept, efalizumab, etanercept, adalimumab and infliximab). The chapters on biological therapies focus on key safety issues. Further chapters focus on such topics as the management of childhood psoriasis and psoriasis in distinctive locations, such as the scalp, face, flexures, palm/soles and nails. Finally, future therapeutic modalities, with the focus on small molecules and potential biological therapies, are discussed.This publication will make significant reading to dermatologists and all physicians dealing with psoriasis, such as general practitioners, psychiatrists, rheumatologists, cardiologists and diabetologists.




World Clinics: Dermatology - Acne


Book Description

First volume in World Clinics: Dermatology series bringing dermatologists up to date with recent advances in treatment of acne. Contributions from experts in Europe, the USA and Asia.




Global Report on Psoriasis


Book Description

This WHO Global report on psoriasis brings the public health impact of psoriasis into focus. The report is written to help raise awareness of the range of ways that psoriasis can affect peoples' lives. It intends to empower policy-makers with practical solutions to improve the health care and social inclusion of people living with psoriasis in their populations. The report highlights that much of the suffering caused by this common and complex disease can be avoided. Improving access to early diagnosis and appropriate treatment for psoriasis requires universally accessible health-care systems that provide people-centered care for patients with complex, lifelong conditions. Governments also have a key role to play in seeking to address the unnecessary social consequences of psoriasis by the challenging the myths and behaviors that lead to the exclusion of patients from healthcare settings and daily life.




Regional Variations of Psoriasis - Volume - I


Book Description

The innate immune response serves as the body's first line of defense against pathogens and is a critical player in psoriasis development. Genetic variations influencing the components of the innate immune system, such as keratinocytes, dendritic cells, and macrophages, significantly affect disease mechanisms. Keratinocytes in psoriatic lesions express heightened levels of antimicrobial peptides (AMPs) like cathelicidin and β-defensin, which are tightly regulated by genetic factors. Increased AMP expression can perpetuate inflammation by acting as chemoattractants for immune cells and by triggering pro-inflammatory cytokine production. Moreover, single nucleotide polymorphisms (SNPs) in genes coding for innate immune receptors, such as Toll-like receptors (TLRs), have been associated with increased susceptibility to psoriasis. For instance, genetic variants affecting TLR signaling can lead to an exaggerated inflammatory response to environmental triggers, such as trauma or infections, commonly associated with psoriasis flares. This implicates TLR-mediated pathways as crucial targets for therapeutic intervention, as modulation of this signaling can alter disease progression.




Regional Variations of Psoriasis - Volume - I


Book Description

The innate immune response serves as the body's first line of defense against pathogens and is a critical player in psoriasis development. Genetic variations influencing the components of the innate immune system, such as keratinocytes, dendritic cells, and macrophages, significantly affect disease mechanisms. Keratinocytes in psoriatic lesions express heightened levels of antimicrobial peptides (AMPs) like cathelicidin and β-defensin, which are tightly regulated by genetic factors. Increased AMP expression can perpetuate inflammation by acting as chemoattractants for immune cells and by triggering pro-inflammatory cytokine production. Moreover, single nucleotide polymorphisms (SNPs) in genes coding for innate immune receptors, such as Toll-like receptors (TLRs), have been associated with increased susceptibility to psoriasis. For instance, genetic variants affecting TLR signaling can lead to an exaggerated inflammatory response to environmental triggers, such as trauma or infections, commonly associated with psoriasis flares. This implicates TLR-mediated pathways as crucial targets for therapeutic intervention, as modulation of this signaling can alter disease progression.




COVID-19 and the Dermatologist, An Issue of Dermatologic Clinics, E-Book


Book Description

This issue of Dermatologic Clinics, guest edited by Dr. Esther Freeman and Devon McMahon, will focus on COVID-19 and the Dermatologist. This issue is one of four selected each year by our series Consulting Editor, Dr. Bruce Thiers. Topics discussed in this issue include but are not limited to Covid-19 as it pertains to Dermatology Residency, Race in Dermatology, Dermatology Practice changes, Global Health Dermatology, Dermatologic Morphologies, Teledermatology, Dermatology Immunology, Occupational dermatology, Biologics, In-Patient Dermatology, Pediatric Dermatology, Registry Update, Dermatopathology, and Effect of COVID-19 on Delayed Skin Cancer Services. - Provides in-depth, clinical reviews on COVID-19 and the Dermatologist, providing actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.




Psoriasis: Advances in Knowledge and Care, An Issue of Dermatologic Clinics


Book Description

Psoriasis is the most prevalent autoimmune disease in the U.S. • ~125 million people worldwide have psoriasis. Commonly misunderstood and interpreted as a “cosmetic problem, psoriasis is a complex and potentially debilitating disease; nearly 60% of people with psoriasis reported their disease to be a large problem in their everyday life. This issue of Dermatologic Clinics devoted exclusively to psoriasis is edited by two leaders of the International Psoriasis Council, Dr Alan Menter and Dr Chris Griffiths. Topics include: Genetics of psoriasis; Immunopathogenesis of psoriasis; Phenotypical expressions of psoriasis; Psoriasis as a systemic disease with multiple comorbidities; Outcomes measures in the assessment of psoriasis in clinical practice and trials; Update on topical therapies for mild to moderate psoriasis; Phototherapy and photochemotherapy (PUVA) for psoriasis; Current and future oral systemic therapies for psoriasis; Current biological therapies for psoriasis; Future biological therapies for psoriasis; Psoriatic arthritis for the dermatologist; Pharmacogenomics and the future of psoriasis therapies. This information that goes to the heart of clinical practice is equally appropriate, beyond dermatologists, for internal medicine clinicians, primary care physicians, bone & joint specialists; hematologists/oncologists, and researchers in genetic targeted therapy development.




Healing Springs


Book Description

The first book to present medical evidence that mineral springs can prevent and cure disease--and to tell you which spas are most effective • Lists more than 200 of the best hot springs and mineral springs in the world and the health conditions best treated at each, with a special emphasis on springs in the U.S. and Canada • Reviews additional healing techniques that best complement bathing in and drinking medicinal waters--such as acupuncture, homeopathy, fasting programs, and fitness training • Includes photos of everything from famous spas to little-known hot springs The Fountain of Youth does exist! Author Nathaniel Altman shows that "taking the waters" is a powerful healing tool that rejuvenates the body and prevents a host of illnesses. Until now, it's been the best-kept secret for promoting and maintaining health and vitality. The use of natural mineral spring water for the prevention and cure of disease dates back 5000 years to the Bronze Age. Hot springs reached their heyday in the United States in the latter part of the 19th century and were well attended until the early 1940s. Balneotherapy--using natural mineral spring water for the prevention and cure of disease--continued to thrive elsewhere in the world and is making a big comeback in the United States. It is an accepted form of mainstream medicine in Europe and Japan, where an abundance of medical evidence shows that in addition to relieving stress, certain mineral waters can help the body heal itself from heart, liver, and kidney problems, skin diseases, asthma, digestive disorders, arthritis, and a host of other health problems.




Itch


Book Description

Advances in itch research have elucidated differences between itch and pain but have also blurred the distinction between them. There is a long debate about how somatic sensations including touch, pain, itch, and temperature sensitivity are encoded by the nervous system. Research suggests that each sensory modality is processed along a fixed, direct-line communication system from the skin to the brain. Itch: Mechanisms and Treatment presents a timely update on all aspects of itch research and the clinical treatment of itch that accompanies many dermatological conditions including psoriasis, neuropathic itch, cutaneous t-cells lymphomas, and systemic diseases such as kidney and liver disease and cancer. Composed of contributions from distinguished researchers around the world, the book explores topics such as: Neuropathic itch Peripheral neuronal mechanism of itch The role of PAR-2 in neuroimmune communication and itch Mrgprs as itch receptors The role of interleukin-31 and oncostatin M in itch and neuroimmune communication Spinal coding of itch and pain Spinal microcircuits and the regulation of itch Examining new findings on cellular and molecular mechanisms, the book is a compendium of the most current research on itch, its prevalence in society, and the problems associated with treatment.