Free-Electron Lasers in the Ultraviolet and X-Ray Regime


Book Description

The main goal of the book is to provide a systematic and didactic approach to the physics and technology of free-electron lasers. Numerous figures are used for illustrating the underlying ideas and concepts and links to other fields of physics are provided. After an introduction to undulator radiation and the low-gain FEL, the one-dimensional theory of the high-gain FEL is developed in a systematic way. Particular emphasis is put on explaining and justifying the various assumptions and approximations that are needed to obtain the differential and integral equations governing the FEL dynamics. Analytical and numerical solutions are presented and important FEL parameters are defined, such as gain length, FEL bandwidth and saturation power. One of the most important features of a high-gain FEL, the formation of microbunches, is studied at length. The increase of gain length due to beam energy spread, space charge forces, and three-dimensional effects such as betatron oscillations and optical diffraction is analyzed. The mechanism of Self-Amplified Spontaneous Emission is described theoretically and illustrated with numerous experimental results. Various methods of FEL seeding by coherent external radiation are introduced, together with experimental results. The world’s first soft X-ray FEL, the user facility FLASH at DESY, is described in some detail to give an impression of the complexity of such an accelerator-based light source. The last chapter is devoted to the new hard X-ray FELs which generate extremely intense radiation in the Angstrøm regime. The appendices contain supplementary material and more involved calculations.




Physics of and Science with X-Ray Free-Electron Lasers


Book Description

Many X-Ray Free-Electron Lasers (X-FELs) have been designed, built and commissioned since the first lasing of the Linac Coherent Light Source in the hard and soft X-ray regions, and great progress has been made in improving their performance and extending their capabilities. Meanwhile, experimental techniques to exploit the unique properties of X-FELs to explore atomic and molecular systems of interest to physics, chemistry, biology and the material sciences have also been developed. As a result, our knowledge of atomic and molecular science has been greatly extended. Nevertheless, there is still much to be accomplished, and the potential for discovery with X-FELs is still largely unexplored. The next generation of scientists will need to be well versed in both particle beams/FEL physics and X-ray photon science. This book presents material from the Enrico Fermi summer school: Physics of and Science with X-Ray Free-Electron Lasers, held at the Enrico Fermi International School of Physics in Varenna, Italy, from 26 June - 1 July 2017. The lectures presented at the school were aimed at introducing graduate students and young scientists to this fast growing and exciting scientific area, and subjects covered include basic accelerator and FEL physics, as well as an introduction to the main research topics in X-FEL-based biology, atomic molecular optical science, material sciences, high-energy density physics and chemistry. Bridging the gap between accelerator/FEL physicists and scientists from other disciplines, the book will be of interest to all those working in the field.




Synchrotron Radiation and Free-Electron Lasers


Book Description

Preliminary concepts -- Synchrotron radiation -- Basic FEL physics -- 1D FEL analysis -- 3D FEL analysis -- Harmonic generation in high-gain FELs -- FEL oscillators and coherent hard X-rays -- Practical considerations and experimental results for high-gain FELs




The Physics of Free Electron Lasers


Book Description

The Free Electron Laser (FEL) will be a crucial tool for research and industrial applications. This book describes the physical fundamentals of FELs on the basis of classical mechanics, electrodynamics, and the kinetic theory of charged particle beams, and will be suitable for graduate students and scientists alike. After a short introduction, the book discusses the theory of the FEL amplifier and oscillator, diffraction effects in the amplifier, and waveguide FEL.




Nonlinear Optics, Quantum Optics, and Ultrafast Phenomena with X-Rays


Book Description

Nonlinear Optics, Quantum Optics, and Ultrafast Phenomena with X-Rays is an introduction to cutting-edge science that is beginning to emerge on state-of-the-art synchrotron radiation facilities and will come to flourish with the x-ray free-electron lasers currently being planned. It is intended for the use by scientists at synchrotron radiation facilities working with the combination of x-rays and lasers and those preparing for the science at x-ray free-electron lasers. In the past decade synchrotron radiation sources have experienced a tremendous increase in their brilliance and other figures of merit. This progress, driven strongly by the scientific applications, is still going on and may actually be accelerating with the advent of x-ray free-electron lasers. As a result, a confluence of x-ray and laser physics is taking place, due to the increasing importance of laser concepts, such as coherence and nonlinear optics to the x-ray community and the importance of x-ray optics to the laser-generation of ultrashort pulses of x-rays.




Synchrotron Light Sources and Free-Electron Lasers


Book Description

Hardly any other discovery of the nineteenth century did have such an impact on science and technology as Wilhelm Conrad Röntgen’s seminal find of the X-rays. X-ray tubes soon made their way as excellent instruments for numerous applications in medicine, biology, materials science and testing, chemistry and public security. Developing new radiation sources with higher brilliance and much extended spectral range resulted in stunning developments like the electron synchrotron and electron storage ring and the freeelectron laser. This handbook highlights these developments in fifty chapters. The reader is given not only an inside view of exciting science areas but also of design concepts for the most advanced light sources. The theory of synchrotron radiation and of the freeelectron laser, design examples and the technology basis are presented. The handbook presents advanced concepts like seeding and harmonic generation, the booming field of Terahertz radiation sources and upcoming brilliant light sources driven by laser-plasma accelerators. The applications of the most advanced light sources and the advent of nanobeams and fully coherent x-rays allow experiments from which scientists in the past could not even dream. Examples are the diffraction with nanometer resolution, imaging with a full 3D reconstruction of the object from a diffraction pattern, measuring the disorder in liquids with high spatial and temporal resolution. The 20th century was dedicated to the development and improvement of synchrotron light sources with an ever ongoing increase of brilliance. With ultrahigh brilliance sources, the 21st century will be the century of x-ray lasers and their applications. Thus, we are already close to the dream of condensed matter and biophysics: imaging single (macro)molecules and measuring their dynamics on the femtosecond timescale to produce movies with atomic resolution.




Insertion Devices for Synchrotron Radiation and Free Electron Laser


Book Description

This book describes the basic properties of charged beam transport and the theory of accelerators with radiative damping. The characteristics of the third generation synchrotron radiation sources are analyzed and compared to those of the first and second generations. This is followed by the conceptual and technological problems associated with the discovery of the fourth generation sources. Within this framework, the role played by free electron laser devices is discussed and relevant theoretical and technological aspects of storage-ring and Linac-based sources are analyzed.




Nanoscale Photonic Imaging


Book Description

This open access book, edited and authored by a team of world-leading researchers, provides a broad overview of advanced photonic methods for nanoscale visualization, as well as describing a range of fascinating in-depth studies. Introductory chapters cover the most relevant physics and basic methods that young researchers need to master in order to work effectively in the field of nanoscale photonic imaging, from physical first principles, to instrumentation, to mathematical foundations of imaging and data analysis. Subsequent chapters demonstrate how these cutting edge methods are applied to a variety of systems, including complex fluids and biomolecular systems, for visualizing their structure and dynamics, in space and on timescales extending over many orders of magnitude down to the femtosecond range. Progress in nanoscale photonic imaging in Göttingen has been the sum total of more than a decade of work by a wide range of scientists and mathematicians across disciplines, working together in a vibrant collaboration of a kind rarely matched. This volume presents the highlights of their research achievements and serves as a record of the unique and remarkable constellation of contributors, as well as looking ahead at the future prospects in this field. It will serve not only as a useful reference for experienced researchers but also as a valuable point of entry for newcomers.




Reflective Optics


Book Description

This is the first book dedicated exclusively to all-reflective imaging systems. It is a teaching tool as well as a practical design tool for anyone who specializes in optics, particularly for those interested in telescopes, infrared, and grazing-incidence systems. The first part of the book describes a unified geometric optical theory of all-reflective imaging systems (from near-normal to grazing incidence) developed from basic principles. The second part discusses correction methods and a multitude of closed-form solutions of well-corrected systems, supplemented with many conventional and unconventional designs examples. This book will be useful to anyone interested in the theory of optical image formation and in the actual design of image-forming instruments.




Structural Biology in Drug Discovery


Book Description

With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field. The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable reference and resource that: Presents the benefits, limitations, and potentiality of major techniques in the field such as X-ray crystallography, NMR, neutron crystallography, cryo-EM, mass spectrometry and other biophysical techniques, and computational structural biology Includes detailed chapters on druggability, allostery, complementary use of thermodynamic and kinetic information, and powerful approaches such as structural chemogenomics and fragment-based drug design Emphasizes the need for the in-depth biophysical characterization of protein targets as well as of therapeutic proteins, and for a thorough quality assessment of experimental structures Illustrates advances in the field of established therapeutic targets like kinases, serine proteinases, GPCRs, and epigenetic proteins, and of more challenging ones like protein-protein interactions and intrinsically disordered proteins