Author : Alfred Burger
Publisher :
Page : 316 pages
File Size : 34,33 MB
Release : 1983-09-23
Category : Medical
ISBN :
This book by a leading author in the field of medicinal chemistry deals with the chemical structure of biologically active compounds. Presents a unique historical overview of drug discovery and design using the historical facts of the pharmacology to reveal the serendipity of discovery and to point toward new structures that may be developed based on what has gone before.
Author : S. N. Pandeya
Publisher : New Age International
Page : 228 pages
File Size : 35,25 MB
Release : 1997
Category : Drugs
ISBN : 9788122409437
The Book Entitled, An Introduction To Drug Design Aims To Optimize The Discovery Of Drugs At A Low Cost And On Occasions To Change Their Pharmacokinetic And Pharmacodyanamic Properties. The Introductory Chapter Which Forms The Basis Of Drug Discovery Is Followed By The Present-Day Thinking Regarding The Best Approaches To Drug Discovery Are Considered. Similarly, There Have Been Major Advances In The Employment Of Computers In Structure-Activity Analysis, And A Discussion Of The State Of The Art In This Area Is Also Included.The Chapter On Qsar Highlights The Role Of Physico-Chemical Parameters In Predicting The Future Course Of Drug Discovery With Rational Drug Design. The Role Of Enzymes In Drug Action Is Well Established, And A Chapter On Design Of Enzyme Inhibitors Is Well Documented. In Addition, The Increased Understanding Of The Design And Utilisation Of Prodrugs Has Led To A Discussion Of The Relevant Issues In This Text.Thus The Book Will Fill The Need Of A Text For Designing New Drugs And The Principles Of New Drug Discovery.
Author : D. C. Young
Publisher : John Wiley & Sons
Page : 344 pages
File Size : 28,35 MB
Release : 2009-01-28
Category : Science
ISBN : 9780470451847
Helps you choose the right computational tools and techniques to meet your drug design goals Computational Drug Design covers all of the major computational drug design techniques in use today, focusing on the process that pharmaceutical chemists employ to design a new drug molecule. The discussions of which computational tools to use and when and how to use them are all based on typical pharmaceutical industry drug design processes. Following an introduction, the book is divided into three parts: Part One, The Drug Design Process, sets forth a variety of design processes suitable for a number of different drug development scenarios and drug targets. The author demonstrates how computational techniques are typically used during the design process, helping readers choose the best computational tools to meet their goals. Part Two, Computational Tools and Techniques, offers a series of chapters, each one dedicated to a single computational technique. Readers discover the strengths and weaknesses of each technique. Moreover, the book tabulates comparative accuracy studies, giving readers an unbiased comparison of all the available techniques. Part Three, Related Topics, addresses new, emerging, and complementary technologies, including bioinformatics, simulations at the cellular and organ level, synthesis route prediction, proteomics, and prodrug approaches. The book's accompanying CD-ROM, a special feature, offers graphics of the molecular structures and dynamic reactions discussed in the book as well as demos from computational drug design software companies. Computational Drug Design is ideal for both students and professionals in drug design, helping them choose and take full advantage of the best computational tools available. Note: CD-ROM/DVD and other supplementary materials are not included as part of eBook file.
Author : Sun Hongmao
Publisher : Woodhead Publishing
Page : 293 pages
File Size : 40,17 MB
Release : 2015-10-05
Category : Medical
ISBN : 0081001053
This book is not going to be an exhaustive survey covering all aspects of rational drug design. Instead, it is going to provide critical know-how through real-world examples. Relevant case studies will be presented and analyzed to illustrate the following: how to optimize a lead compound whether one has high or low levels of structural information; how to derive hits from competitors' active compounds or from natural ligands of the targets; how to springboard from competitors' SAR knowledge in lead optimization; how to design a ligand to interfere with protein-protein interactions by correctly examining the PPI interface; how to circumvent IP blockage using data mining; how to construct and fully utilize a knowledge-based molecular descriptor system; how to build a reliable QSAR model by focusing on data quality and proper selection of molecular descriptors and statistical approaches. A Practical Guide to Rational Drug Design focuses on computational drug design, with only basic coverage of biology and chemistry issues, such as assay design, target validation and synthetic routes. - Discusses various tactics applicable to daily drug design - Readers can download the materials used in the book, including structures, scripts, raw data, protocols, and codes, making this book suitable resource for short courses or workshops - Offers a unique viewpoint on drug discovery research due to the author's cross-discipline education background - Explores the author's rich experiences in both pharmaceutical and academic settings
Author : Arun K. Ghosh
Publisher : John Wiley & Sons
Page : 474 pages
File Size : 29,58 MB
Release : 2014-08-11
Category : Medical
ISBN : 3527333657
Drug design is a complex, challenging and innovative research area. Structure-based molecular design has transformed the drug discovery approach in modern medicine. Traditionally, focus has been placed on computational, structural or synthetic methods only in isolation. This one-of-akind guide integrates all three skill sets for a complete picture of contemporary structure-based design. This practical approach provides the tools to develop a high-affinity ligand with drug-like properties for a given drug target for which a high-resolution structure exists. The authors use numerous examples of recently developed drugs to present "best practice" methods in structurebased drug design with both newcomers and practicing researchers in mind. By way of a carefully balanced mix of theoretical background and case studies from medicinal chemistry applications, readers will quickly and efficiently master the basic skills of successful drug design. This book is aimed at new and active medicinal chemists, biochemists, pharmacologists, natural product chemists and those working in drug discovery in the pharmaceutical industry. It is highly recommended as a desk reference to guide students in medicinal and chemical sciences as well as to aid researchers engaged in drug design today.
Author : Javier Luque
Publisher : Royal Society of Chemistry
Page : 443 pages
File Size : 12,16 MB
Release : 2012
Category : Medical
ISBN : 1849733538
This title covers a wide range of topics relevant to the development of drugs. It provides a comprehensive description of the major methodological strategies available for rational drug discovery.
Author : David J. Livingstone
Publisher : Royal Society of Chemistry
Page : 517 pages
File Size : 17,79 MB
Release : 2012
Category : Medical
ISBN : 1849731667
This book brings together drug design practitioners, all leaders in their field, who are actively advancing the field of quantitative methods to guide drug discovery, from structure-based design to empirical statistical models - from rule-based approaches to toxicology to the fields of bioinformatics and systems biology. The aim of the book is to show how various facets of the drug discovery process can be addressed in a quantitative fashion (ie: numerical analysis to enable robust predictions to be made). Each chapter includes a brief review of the topic showing the historical development of.
Author : Mukund S. Chorghade
Publisher : John Wiley & Sons
Page : 478 pages
File Size : 38,58 MB
Release : 2006-07-18
Category : Science
ISBN : 047178009X
From first principles to real-world applications -- here is the first comprehensive guide to drug discovery and development Modern drug discovery and development require the collaborative efforts of specialists in a broadarray of scientific, technical, and business disciplines--from biochemistry to molecular biology, organic chemistry to medicinal chemistry, pharmacology to marketing. Yet surprisingly, until now, there were no authoritative references offering a complete, fully integrated picture of the process. The only comprehensive guide of its kind, this groundbreaking two-volume resource provides an overview of the entire sequence of operations involved in drug discovery and development--from initial conceptualization to commercialization to clinicians and medical practitioners. Volume 1: Drug Discovery describes all the steps in the discovery process, including conceptualizing a drug, creating a library of candidates for testing, screening candidates for in vitro and in vivo activity, conducting and analyzing the results of clinical trials, and modifying a drug as necessary. Volume 2: Drug Development delves into the nitty-gritty details of optimizing the synthetic route, drug manufacturing, outsourcing, and marketing--including drug coloring and delivery methods. Featuring contributions from a world-class team of experts, Drug Discovery and Development: * Features fascinating case studies, including the discovery and development of erythromycin analogs, Tagamet, and Ultiva (remifentanil) * Discusses the discovery of medications for bacterial infections, Parkinson's disease, psoriasis, peptic ulcers, atopic dermatitis, asthma, and cancer * Includes chapters on combinatorial chemistry, molecular biology-based drug discovery, genomics, and chemogenomics Drug Discovery and Development is an indispensable working resource for industrialchemists, biologists, biochemists, and executives who work in the pharmaceutical industry.
Author :
Publisher : Academic Guru Publishing House
Page : 268 pages
File Size : 17,83 MB
Release : 2024-04-02
Category : Study Aids
ISBN : 819705911X
‘Introduction to Medicinal Chemistry’ serves as a comprehensive guide to exploring the dynamic and evolving field of medicinal chemistry. Written with precision and expertise, this book provides a practical journey into the principles and applications underpinning the development of pharmaceutical agents. With a focus on the intersection of chemistry and medicine, the text delves deeply into the molecular mechanisms controlling drug action, emphasizing the importance of understanding structure-activity relationships. This book highlights the complexities of drug design, synthesis and optimization through the fundamental concepts of medicinal chemistry. It meets the needs of both novice learners and experienced practitioners in the field, offering a balanced mix of theoretical foundations and practical applications. Readers will find explanations on the chemical basis of various diseases, identification of drug targets, and design of molecules with therapeutic potential. Notably, the author uses a clear writing style, which highlights complex concepts and facilitates an intuitive understanding of the subject matter. The inclusion of case studies and real-world examples further enhances the practical relevance of the book, fostering a deeper appreciation for the role of medicinal chemistry in modern health care. ‘Introduction to Medicinal Chemistry’ stands as an indispensable resource for students, researchers, and professionals seeking a holistic understanding of the principles of drug discovery and development. Its broad coverage and accessible approach make it an invaluable tool for those wishing to unravel the secrets of medicinal chemistry and contribute to the advancement of pharmaceutical science.
Author : T. Durai Ananda Kumar
Publisher : CRC Press
Page : 486 pages
File Size : 34,91 MB
Release : 2022-06-02
Category : Medical
ISBN : 1000603881
The newer research areas in pharmaceutical sciences, particularly molecular modeling and simulations, prompted a more efficient drug discovery process. Informatics integrated with pharmaceutical sciences (cheminformatics and bioinformatics) became an essential component of drug research. Drug informatics such as genomics and proteomics assists in the Rational Drug Design (RDD). This emerging discipline is known as “Computer-Aided Drug Design (CADD)”, which has profound application in rational drug design (RDD). The advanced and adequate practice in drug design informatics is essential for pharmacy graduates. Hence, a companion for acquiring knowledge on these concepts is vital. The students of B. Pharmacy, M. Pharmacy (Pharmaceutical Chemistry, Pharmacology, and Pharmaceutics), biotechnology, biomedical engineering and other interdisciplinary fields may find this book as a reference guide. The salient features of this book are: • Systematic and simple approach • Emphasis on traditional and modern drug design strategies • Comprehensive coverage for the current advances in the drug design • Experimental section to ensure hands-on-experience Note: T& F does not sell or distribute the Hardback in India, Pakistan, Nepal, Bhutan, Bangladesh and Sri Lanka.
