Thyroid Hormone Metabolism


Book Description




Molecular Basis of Thyroid Hormone Action


Book Description

Molecular Basis of Thyroid Hormone Action focuses on the actions of thyroid hormones in eukaryotic cells. This book discusses the profound effects of thyroid hormones on the growth, development, and metabolism of practically all tissues of higher organisms. Organized into 15 chapters, this volume starts with an overview of the kinetic interrelationships of hormone bound to specific receptors and hormone associated with other tissue and plasma pools in living animals. This book then discusses the thyroid hormone receptor, a chromatin-associated protein that appears to mediate the actions of the thyroid hormones in mammalian cells. Other chapters consider the localization of the receptors in chromatin. This book further discusses how thyroid hormones stimulate the accumulation of specific mRNA molecules in cell culture as well as in tissues in vivo. This book is intended for readers who are interested in cell and molecular biology. Endocrinologists will also find this book extremely useful.







Thyroid Hormone


Book Description

Thyroid hormone, Volume 106, the latest release in the Vitamins and Hormones series first published in 1943 provides up-to-date information on crystal structures and basic structural studies on neurotrophins and their receptors, neurotrophin functions and the biological actions of neurotrophins related to clinical conditions and disease. This new release focuses on timely topics, including the Nuclear Import and Export of the Thyroid Hormone Receptor, the Thyroid hormone and the white matter of the central nervous system: from development to repair, Thyroid hormone and astrocyte differentiation, and the Molecular Basis of Nongenomic Actions of Thyroid Hormone, amongst other topics. Presents the latest information on thyroid hormone Provides a long-running series that focuses on updates and advances in vitamins and hormones Covers single molecules or diseases that are related to vitamins or hormones, with the topic broadly interpreted to include related substances




Comprehensive Handbook of Iodine


Book Description

Over two billion people worldwide are at risk for the spectrum of disorders known as "The Iodine Deficiency Disorders." 1-10% will suffer cretinism; 5-30% will have some sort of brain damage or neurological impairment and 30-70% will be hypothyroid. The causes of iodine deficiencies can be considered from both simplistic and more complex perspectives: From the leaching of iodine from soil resulting in crops with low iodine content to malnutrition resulting in impaired iodine absorption. Poor dietary diversification and impoverished socio-economic development can also lead to iodine deficiencies. Although it is possible to diagnose and treat deficiencies, there is still an ongoing dialogue regarding the detailed molecular pathology of iodine homeostatis, how hypothyroidism impacts the body tissues, and efficient diagnosis and treatment of the Iodine Deficiency Disorders. This Handbook provides a resource of information on the various pathways and processes based on different countries or diseases. Because there is a constant flow of new information on iodine and related disorders, the goal of this Handbook is to provide a base of scientific information upon which additional knowledge can be applied. Provides important information on one of the most common micro-nutrient deficiencies in the world, the most important "single nutrient-multiple consequences" paradigm today Includes information on iodine-related diseases, including those that are common, preventable and treatable Provides insight from a broad perspective of viewpoints -- from subcellular transports to economic impact




The Thyroid Hormones


Book Description

International Series of Monographs on Pure and Applied Biology, Volume 1: The Thyroid Hormones focuses on the reactions, characteristics, and chemistry of thyroid hormones. The selection first offers information on the chemistry of thyroxine, iodinated compounds of the thyroid glands, and biosynthesis of the thyroid hormones. Discussions focus on the constitution of desiodothyroxine, diiodotyrosine, biological significance of the iodothyronines, rate of secretion of the thyroid hormone into the circulation, and formation of thyroxine from diiodotyrosine in vitro. The manuscript then takes a look at the transport and physiological actions of the thyroid hormones. Topics include thyroxine-binding by other serum proteins, extravascular fluids, and tissue proteins, effect on nitrogen and lipid metabolism, growth, maturation, and differentiation, and effect on the cardiovascular system and blood. The book examines the mechanism of action of thyroid hormones, extrathyroidal distribution and metabolism of iodine, and biochemical pathways of thyroid hormone metabolism. The text is a dependable reference for readers interested in the reactions, characteristics, and chemistry of thyroid hormones.




Medicare Coverage of Routine Screening for Thyroid Dysfunction


Book Description

When the Medicare program was established in 1965, it was viewed as a form of financial protection for the elderly against catastrophic medical expenses, primarily those related to hospitalization for unexpected illnesses. The first expansions to the program increased the eligible population from the retired to the disabled and to persons receiving chronic renal dialysis. It was not until 1980 that an expansion of services beyond those required "for the diagnosis or treatment of illness or injury or to improve the functioning of a malformed body member" was included in Medicare. These services, known as preventive services, are intended either to prevent disease (by vaccination) or to detect disease (by diagnostic test) before the symptoms of illness appear. A Committee was formed "to conduct a study on the addition of coverage of routine thyroid screening using a thyroid stimulating hormone test as a preventive benefit provided to Medicare beneficiaries under Title XVIII of the Social Security Act for some or all Medicare beneficiaries."




Thyroid Hormones


Book Description

Hormonal Proteins and Peptides, Volume VI: Thyroid Hormones is a compilation of papers that details the various aspects, chemical properties, effects, and history of thyroid hormones. The book covers a wide range of topics related to the study of thyroid hormones. Six chapters are devoted to the various aspects of thyroid hormones. Chapter 1 deals with the chemistry of human thyrotropin. Chapters 2 and 3 survey the chemistry of thyroid hormones and analogs, focusing on synthesis and structure-activity relationships. Chapter 4 presents thyroxin action and the possible direct participation of thyroxin in catecholamine pathways in the nervous system. Chapter 5 discusses the thyroid hormone action during amphibian metamorphosis at the cellular and molecular levels. An account of the evolution of the thyroid function is given in Chapter 6. The final chapter delves on the historical aspect of thyroid hormones. Biochemists, physicians, pharmacologists, researchers, and students in the medical field will benefit from this book.