Urologic Principles and Practice


Book Description

This book fulfils the need for a general urology text primarily urologists in training. It has a novel format by having a clinical chapter always preceded by a scientific foundation chapter. The scientific chapter is geared toward answering questions for boards and understanding pathophysiology, is concise and relevant. The clinical chapter is written around evidence-based medicine and in "how-to" format with algorithms, with reference to AUA & EAU guidelines, well illustrated.




Phosphodiesterases as Drug Targets


Book Description

Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that selectively target this class of enzymes. Novel characteristics of PDEs are viewed as unique opportunities to increase specificity and selectivity when designing novel compounds for certain therapeutic indications. This chapter provides a summary of the major concepts related to the design and use of PDE inhibitors.




Urinary Tract


Book Description

The basic anatomy and physiology of the urinary tract, the validity of animal models and other methodological considerations as well as a range of potential therapeutic targets are comprehensively reviewed by leading international experts, making this a unique reference source for basic scientists and research-minded clinicians alike










Campbell-Walsh Urology E-Book


Book Description

Internationally lauded as the preeminent text in the field, Campbell-Walsh Urology continues to offer the most comprehensive coverage of every aspect of urology. Perfect for urologists, residents, and practicing physicians alike, this updated text highlights all of the essential concepts necessary for every stage of your career, from anatomy and physiology through the latest diagnostic approaches and medical and surgical treatments. The predominant reference used by The American Board of Urology for its examination questions. Algorithms, photographs, radiographs, and line drawings illustrate essential concepts, nuances of clinical presentations and techniques, and decision making. Key Points boxes and algorithms further expedite review. Features hundreds of well-respected global contributors at the top of their respective fields. A total of 22 new chapters, including Evaluation and Management of Men with Urinary Incontinence; Minimally-Invasive Urinary Diversion; Complications Related to the Use of Mesh and Their Repair; Focal Therapy for Prostate Cancer; Adolescent and Transitional Urology; Principles of Laparoscopic and Robotic Surgery in Children; Pediatric Urogenital Imaging; and Functional Disorders of the Lower Urinary Tract in Children. Previous edition chapters have been substantially revised and feature such highlights as new information on prostate cancer screening, management of non–muscle invasive bladder cancer, and urinary tract infections in children. Includes new guidelines on interstitial cystitis/bladder pain syndrome, uro-trauma, and medical management of kidney stone disease. Anatomy chapters have been expanded and reorganized for ease of access. Boasts an increased focus on robotic surgery, image-guided diagnostics and treatment, and guidelines-based medicine. Features 130 video clips that are easily accessible via Expert Consult. Periodic updates to the eBook version by key opinion leaders will reflect essential changes and controversies in the field. Expert Consult eBook version included with purchase. This enhanced eBook experience offers access to all of the text, figures, tables, diagrams, videos, and references from the book on a variety of devices.







Smooth Muscle Spontaneous Activity


Book Description

This book presents the commonality and heterogeneity of the mechanisms underlying smooth muscle spontaneous activity in various smooth muscle organs and in addition discusses their malfunctions in disease and their potential as novel therapeutic targets. To facilitate understanding, the volume is divided into five parts and covers 16 organs: airways, gastrointestinal tract (phasic muscle, tonic muscle), renal pelvis, ureter, urinary bladder, urethra, corporal tissue, prostate, uterus, oviducts, seminal vesicle, artery, vein, microvasculature, and lymphatic vessels. This structure will help readers to comprehend the most up-to-date information on the similarities and differences in the contractile mechanisms driving various smooth muscles as well as their potential manipulations in particular visceral organ pathologies. The vast advancements in gene, electrical recording, and imaging technologies in this field are also discussed, with review of past achievements and consideration of likely future developments. This book will be of worldwide interest to clinicians, students, and researchers alike.




cGMP: Generators, Effectors and Therapeutic Implications


Book Description

After the discovery of endogenous NO formation in the late '80s and the 1998 Nobel Prize in Physiology or Medicine, many researchers and physicians again became interested in the NO/sGC interaction and cGMP-dependent signaling. This book is an enthusiastic celebration of cyclic guanosine monophosphate (cGMP) and amply illustrates the importance of this field of science to patients and the way in which the field has evolved. It is exclusively devoted to this exciting and important signaling molecule, addressing all recent advances in understanding guanylate cyclase regulation, NO/sGC interactions, cGMP effector mechanisms and their pathophysiological and pharmacological implications. Particular attention will also be given to clinical applications of the novel cGMP-elevating drugs which are on the horizon, thus spanning the continuum from basic science to clinic.