Enzyme Induction in Man
Author : Eero A. Sotaniemi
Publisher : Taylor & Francis Group
Page : 264 pages
File Size : 45,87 MB
Release : 1987
Category : Medical
ISBN :
Author : Eero A. Sotaniemi
Publisher : Taylor & Francis Group
Page : 264 pages
File Size : 45,87 MB
Release : 1987
Category : Medical
ISBN :
Author : M. C. L' E. Orme
Publisher :
Page : pages
File Size : 18,50 MB
Release : 1974
Category :
ISBN :
Author : Dennis Parke
Publisher : Springer Science & Business Media
Page : 333 pages
File Size : 16,83 MB
Release : 2012-12-06
Category : Science
ISBN : 1461589541
Our present concepts ofthe regulation of enzyme activity in the cell have been largely based on the extensive body of work which has been carried out with micro-organisms. A distinction between constitutive and adaptive enzymes had already been made well before World War II and work on enzyme adaptation, both in yeast and bacteria, was done by several workers, especially Marjorie Stephenson and her group in Cambridge in the 1930s. In studies starting about 1947 Stanier demonstrated that the oxidation of aromatic compounds by species of Pseudomonas involved the coordinate and sequential induction of a group of enzymes concerned in the orderly catabolism of a substrate which acted as the inducer. The investigations of Umbarger and of Pardee, both in 1956, established the principle, which is now firmly established for almost all anabolic reaction chains, that the first 'committed' step in a biosynthetic pathway is sensitive to feedback control by the final product of the particular reaction sequence. This control can be exercised in two ways. It can either act on the rate of formation of the enzyme or it can affect the activity of the latter without altering the concentration of the enzyme.
Author : Balz Kirchhof
Publisher :
Page : 24 pages
File Size : 46,1 MB
Release : 1979
Category :
ISBN :
Author : H. Gerhard Vogel
Publisher : Springer
Page : 0 pages
File Size : 18,66 MB
Release : 2013-02-27
Category : Medical
ISBN : 9783642252396
-A landmark in the continuously changing world of drugs -Essential reading for scientists and managers in the pharmaceutical industry involved in drug finding, drug development and decision making in the development process -Of use for government institutions and committees working on official guidelines for drug evaluation worldwide
Author : Eero A. Sotaniemi
Publisher :
Page : 37 pages
File Size : 22,66 MB
Release : 1986
Category :
ISBN :
Author :
Publisher : Academic Press
Page : 288 pages
File Size : 29,15 MB
Release : 2019-07-13
Category : Medical
ISBN : 0128173173
Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series
Author : H.Gerhard Vogel
Publisher : Springer Science & Business Media
Page : 576 pages
File Size : 27,5 MB
Release : 2010-12-15
Category : Medical
ISBN : 3540898905
Drug Discovery and Evaluation has become a more and more difficult, expensive and time-consuming process. The effect of a new compound has to be detected by in vitro and in vivo methods of pharmacology. The activity spectrum and the potency compared to existing drugs have to be determined. As these processes can be divided up stepwise we have designed a book series "Drug Discovery and Evaluation" in the form of a recommendation document. The methods to detect drug targets are described in the first volume of this series "Pharmacological Assays" comprising classical methods as well as new technologies. Before going to man, the most suitable compound has to be selected by pharmacokinetic studies and experiments in toxicology. These preclinical methods are described in the second volume „Safety and Pharmacokinetic Assays". Only then are first studies in human beings allowed. Special rules are established for Phase I studies. Clinical pharmacokinetics are performed in parallel with human studies on tolerability and therapeutic effects. Special studies according to various populations and different therapeutic indications are necessary. These items are covered in the third volume: „Methods in Clinical Pharmacology".
Author : Georg Hennemann
Publisher : Marcel Dekker
Page : 656 pages
File Size : 12,24 MB
Release : 1986
Category : Medical
ISBN :
Author : Thomas R.E. Barnes
Publisher : Academic Press
Page : 304 pages
File Size : 50,18 MB
Release : 2013-10-22
Category : Medical
ISBN : 1483288102
In line with other volumes in the Neuroscience Perspectives Series, this volume covers the background, pharmacology, molecular biology, and biochemistry of antipsychotic drugs, together with an overview assessment of the therapeutic considerations. Over the past 40 years, the effectiveness of conventional neuroleptic agents for psychotic illness has been offset by a wide range of adverse side-effects, including motor side-effects like parkinsonism. Studies show that lowering doses may still produce the antipsychotic effect while lessening the risk of side-effects. As all available antispychotic drugs are able to block dopamine, specifically D2 receptors, doses below the threshold level for producing acute motor disorder can still be therapeutically effective. With the identification and characterization of multiple dopamine receptors, the possibility of more selective drugs with better side-effect potential has arisen. Other novel antipsychotic agents include D1 receptor blockers, partial dopamine agonists and non-dopamine drugs such as 5-HT receptor blockers, sigma receptor antagonists and NMDA receptor agonists. This volume reviews both the basic science of the conventional and atypical neuroleptics and their present and potential therapeutic use.