Millimeter-Scale Magnetically Actuated Robotic Tools for Surgery and Cell Manipulation


Book Description

Small scale robots are precise end-effectors that can manipulate objects with a high degree of accuracy. Many surgical and on-chip tasks can be performed by manipulating these robots in their dedicated environments. Mobile untethered surgical robots are an attractive research area because of their ability to maneuver inside small and constrained environments and perform tasks that were previously considered infeasible. These robots enable us to make surgery minimally invasive. Surgeons can drill a hole in your skull and insert the tools inside the ventricles from where they can navigate their way to either cut or grasp tissue. Because these robots are too small for electronics and on-board power, they are often actuated remotely using magnetic fields as these field can penetrate most environments and are relatively safe for biological organisms. This makes them an ideal tool to use inside the human body and for on-chip applications. Magnetic tools can be developed and placed inside microfluidic platforms for cell manipulation such as sorting and stimulation. Both on-chip and mobile devices are explored in this thesis focusing on applications related to cell manipulation as well as surgical tools. Specifically, this thesis involves a discussion on the development of a pair of micro-surgical scissors for cutting of soft tissues as well as a magnetically oscillating beam that can be used to apply shear stress to cells and used for cell sorting purposes.




Robotic Cell Manipulation


Book Description

Robotic Cell Manipulation introduces up-to-date research to realize this new theme of medical robotics. The book is organized in three levels: operation tools (e.g., optical tweezers, microneedles, dielectrophoresis, electromagnetic devices, and microfluidic chips), manipulation types (e.g., microinjection, transportation, rotation fusion, adhesion, separation, etc.), and potential medical applications (e.g., micro-surgery, biopsy, gene editing, cancer treatment, cell-cell interactions, etc.). The technology involves different fields such as robotics, automation, imaging, microfluidics, mechanics, materials, biology and medical sciences. The book provides systematic knowledge on the subject, covering a wide range of basic concepts, theories, methodology, experiments, case studies and potential medical applications. It will enable readers to promptly conduct a systematic review of research and become an essential reference for many new and experienced researchers entering this unique field. Introduces the applications of robot-assisted manipulation tools in various cell manipulation tasks Defines many essential concepts in association with the robotic cell manipulation field, including manipulation strategy and manipulation types Introduces basic concepts and knowledge on various manipulation devices and tasks Describes some cutting-edge cell manipulation technologies and case studies




Small-Scale Robotics From Nano-to-Millimeter-Sized Robotic Systems and Applications


Book Description

This book contains selected contributions from some of the most renowned researchers in the field of small-scale robotics, based in large part on invited presentations from the workshop “The Different Sizes of Small-Scale Robotics: from Nano-, to Millimeter-Sized Robotic Systems and Applications,” which was held in conjunction with the conjunction with the International Conference on Robotics and Automation (ICRA 2013), in May 2013 in Karlsruhe, Germany. With many potential applications in areas such as medicine, manufacturing or search and rescue, small-scale robotics represent a new emerging frontier in robotics research. The aim of this book is to provide an insight to ongoing research and future directions in this novel, continuously evolving field, which lies at the intersection of engineering, computer science, material science and biology.




Electromagnetic Actuation and Sensing in Medical Robotics


Book Description

This book highlights electromagnetic actuation (EMA) and sensing systems for a broad range of applications including targeted drug delivery, drug-release-rate control, catheterization, intravitreal needleless injections, wireless magnetic capsule endoscopy, and micromanipulations. It also reviews the state-of-the-art magnetic actuation and sensing technologies with remotely controlled targets used in biomedicine.




Micro- and Nanomanipulation Tools


Book Description

Combining robotics with nanotechnology, this ready reference summarizes the fundamentals and emerging applications in this fascinating research field. This is the first book to introduce tools specifically designed and made for manipulating micro- and nanometer-sized objects, and presents such examples as semiconductor packaging and clinical diagnostics as well as surgery. The first part discusses various topics of on-chip and device-based micro- and nanomanipulation, including the use of acoustic, magnetic, optical or dielectrophoretic fields, while surface-driven and high-speed microfluidic manipulation for biophysical applications are also covered. In the second part of the book, the main focus is on microrobotic tools. Alongside magnetic micromanipulators, bacteria and untethered, chapters also discuss silicon nano- and integrated optical tweezers. The book closes with a number of chapters on nanomanipulation using AFM and nanocoils under optical and electron microscopes. Exciting images from the tiniest robotic systems at the nano-level are used to illustrate the examples throughout the work. A must-have book for readers with a background ranging from engineering to nanotechnology.




Design, Modelling, and Control of Soft-Bodied Magnetic Miniature Robots


Book Description

Miniature robots promise radical improvements in microengineering and disease diagnosis and therapy. Their microscopic sizes allow them to access small and constrained workspaces that cannot be reached previously and perform tasks with accuracy and delicacy. However, their minute bodies also prevent them from carrying on-board components, such as electronics, batteries, and sensors. Thus, there exist a number of unique open problems in miniature robotics, which require novel strategies other than the conventional ones for robots at a larger size scale. In particular, the design, modelling, and control of soft-bodied magnetic miniature robots, which deform in magnetic fields to realize functionalities, have not been well studied, whilst their potential significant impacts have been shown on several areas. In this research, I design, fabricate, model, and control soft-bodied magnetic miniature robots to achieve functionalities at the millimeter and submillimeter scale. A microgripper, a miniature swimmer, and a microobject sorter are developed for cargo picking-and-placing, microscopic propulsion, and microobject sorting, respectively. A global magnetic field serves as the sole medium to deliver power and signals to these small-scale devices that work as robotic end-effectors. The magnetization pattern of each robot is programmed such that it exhibits the desired reactions in the magnetic field. Models are derived to explain and predict the behavior of these devices. Feedback controllers are developed to manipulate them in autonomous robotic tasks. Moreover, novel schemes are formulated to independently and simultaneously control two devices of the same kind using a single magnetic field without additional inputs. The successful realizations of these fundamental functionalities at (sub)millimeter scale using soft-bodied magnetic miniature robots indicate their promising potentials of achieving a large variety of complex capacities and being applied to a wide range of applications. The knowledge obtained from this research could provide insights for designing miniature robots with respect to specific task requirements. Preliminary biocompatibility tests reveal no negative effect on living cells from these robots, suggesting a promising outlook of these devices in bio-related areas. Potential applications of the proposed miniature robots include targeted drug delivery, minimally invasive surgery, on-chip cell diagnosis, microassembly, and generic laboratory operations.




Untethered Small-Scale Robots for Biomedical Applications


Book Description

Untethered Small-Scale Robots for Biomedical Applications introduces the principle, design, fabrication and application of small-scale robots for biomedical applications. Robots in the scale of nanometer, micrometer and millimeter are described in detail, along with their impact on the field of biomedical engineering. The selected examples of robots across different scales are of the most essential and innovative designs in a small-scale robot with various application settings for biomechanics characterization, drug delivery and surgical procedure. The representative robots represented operate robustly and safely in complex physiological environments where they have a transformative impact in bioengineering and healthcare. This book will lead the audience to the field of small-scale robots through the description of the physics in the small scale, design and fabrication of small-scale robots, and how these robots may impact the future of biomedical studies and minimally-invasive surgical procedures. Provides a comprehensive review of the current advances in biomedical untethered mobile milli/microrobots Describes the most representative small-scale robots in detail, including design, fabrication, control and function aspects Presents the imminent potential impacts of biomedical microrobots Discusses the existing challenges and emerging concepts associated with designing such a miniaturized robot for operation inside a biological environment for biomedical applications




Soft and Stiffness-controllable Robotics Solutions for Minimally Invasive Surgery: The STIFF-FLOP Approach


Book Description

Soft and Stiffness-controllable Robotics Solutions for Minimally Invasive Surgery presents the results of a research project, funded by European Commission, STIFF-FLOP: STIFFness controllable Flexible and Learn-able manipulator for surgical Operations. In Minimally Invasive Surgery (MIS), tools go through narrow openings and manipulate soft organs that can move, deform, or change stiffness. There are limitations on modern laparoscopic and robot-assisted surgical systems due to restricted access through Trocar ports, lack of haptic feedback, and difficulties with rigid robot tools operating inside a confined space filled with organs. Also, many control algorithms suffer from stability problems in the presence of unexpected conditions. Yet biological “manipulators”, like the octopus arm can manipulate objects while controlling the stiffness of selected body parts and being inherently compliant when interacting with objects. STIFF-FLOP robot is an innovative soft robotic arm that can squeeze through a standard MIS, reconfigure itself and stiffen by hydrostatic actuation to perform compliant force control tasks while facing unexpected situations. Technical topics discussed in the book include: Soft actuatorsContinuum soft manipulatorsControl, kinematics and navigation of continuum manipulatorsOptical sensors for force, torque, and curvatureHaptic feedback and human interface for surgical systemsValidation of soft stiffness controllable robots




Mobile Microrobotics


Book Description

The first textbook on micron-scale mobile robotics, introducing the fundamentals of design, analysis, fabrication, and control, and drawing on case studies of existing approaches. Progress in micro- and nano-scale science and technology has created a demand for new microsystems for high-impact applications in healthcare, biotechnology, manufacturing, and mobile sensor networks. The new robotics field of microrobotics has emerged to extend our interactions and explorations to sub-millimeter scales. This is the first textbook on micron-scale mobile robotics, introducing the fundamentals of design, analysis, fabrication, and control, and drawing on case studies of existing approaches. The book covers the scaling laws that can be used to determine the dominant forces and effects at the micron scale; models forces acting on microrobots, including surface forces, friction, and viscous drag; and describes such possible microfabrication techniques as photo-lithography, bulk micromachining, and deep reactive ion etching. It presents on-board and remote sensing methods, noting that remote sensors are currently more feasible; studies possible on-board microactuators; discusses self-propulsion methods that use self-generated local gradients and fields or biological cells in liquid environments; and describes remote microrobot actuation methods for use in limited spaces such as inside the human body. It covers possible on-board powering methods, indispensable in future medical and other applications; locomotion methods for robots on surfaces, in liquids, in air, and on fluid-air interfaces; and the challenges of microrobot localization and control, in particular multi-robot control methods for magnetic microrobots. Finally, the book addresses current and future applications, including noninvasive medical diagnosis and treatment, environmental remediation, and scientific tools.




Engineering Approaches to Mechanical and Robotic Design for Minimally Invasive Surgery (MIS)


Book Description

Within the past twenty years, the field of robotics has been finding many areas of applications ranging from space to underwater explo rations. One of these areas which is slowly gaining popularity among the users group is the notion of service robotics. This book is an in vestigation and exploration of engineering principles in the design and development of mechanisms and robotic devices that can be used in the field of surgery. Specifically the results of this book can be used for designing tools for class of Minimally Invasive Surgery (MIS). Generally, Minimal Invasive Surgery (MIS), e. g. laparoscopic surgery, is performed by using long surgical tools, that are inserted through small incisions at the ports of entry to the body (e. g. abdominal wall) for reaching the surgical site. The main drawback of current designs of en doscopic tools is that they are not able to extend all the movements and sensory capabilities of the surgeon's hand to the surgical site. By im proving surgical procedures, training, and more practice, it is possible for surgeons to reduce completion time for each task and increase their level of skill. However, even in the best cases the level of performance of a surgeon in Minimally Invasive Surgery is still a fraction of the con ventional surgery. Any dramatically improvement is usually driven by introduction of new tools or systems that in turn bring totally new pro cedures and set of skills.