› › Nucleic Acid Therapeutics In Cancer

Nucleic Acid Therapeutics in Cancer

Author : Alan M. Gewirtz

Publisher : Springer Science & Business Media

Page : 300 pages

File Size : 17,87 MB

Release : 2004-03-25

Category : Medical

ISBN : 1592597777

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Book Description

A cutting-edge review of the important issues underlying the therapeutic use of nucleic acid-mediated gene silencing. Topics range from basic methodology and delivery to targeting and clinical targets. The authors thoroughly explain the latest developments in RNA biology, as well as the underpinnings of RNA interference, oligodeoxynucleotide delivery into cells, and strategies for targeting these molecules to accessible regions within the mRNA. They also provide some examples of how these new therapeutic compounds are being used clinically.



Prospects for Antisense Nucleic Acid Therapy of Cancer and AIDS

Author : Eric Wickstrom

Publisher : Wiley-Liss

Page : 296 pages

File Size : 40,36 MB

Release : 1991-10-18

Category : Medical

ISBN :

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Book Description

A wide range of new technology involving a direct genetic approach to the treatment of disease using nucleic acid therapeutics is the main focus of this absorbing book. Provides in-depth coverage of the rapid progress of this new technology, from its theoretical stage to its current position at the verge of experimental applications, along with provocative discussions of the therapeutic implications.





Nucleic Acids as Gene Anticancer Drug Delivery Therapy

Author : Loutfy H. Madkour

Publisher : Academic Press

Page : 652 pages

File Size : 18,78 MB

Release : 2019-08-27

Category : Science

ISBN : 0128197781

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Book Description

Nucleic Acids as Gene Anticancer Drug Delivery Therapy highlights the most recent developments in cancer treatment using nucleic acids, nanoparticles and polymer nanoparticles for genomic nanocarriers as drug delivery, including promising opportunities for targeted and combination therapy. The development of a wide spectrum of nanoscale technologies is beginning to change the scientific landscape in terms of disease diagnosis, treatment, and prevention. This book presents the use of nanotechnology for medical applications, focusing on its use for anticancer drug delivery. Various intelligent drug delivery systems such as inorganic nanoparticles and polymer-based drug delivery are discussed. The use of smart drug delivery systems seems to be a promising approach for developing intelligent therapeutic systems for cancer immunotherapies and is discussed in detail along with nucleic acid-targeted drug delivery combination therapy for cancer. Nucleic Acids as Gene Anticancer Drug Delivery Therapy will be a useful reference for pharmaceutical scientists, pharmacologiests, and those involved in nanotechnology and cancer research. - Discusses intelligent drug delivery systems such as inorganic nanoparticles and polymer-based drug delivery - Contains a comprehensive comparison of various delivery systems, listing their advantages and limitations - Presents combination therapy as a new hope for enhancing current gene-based treatment efficacy



Advances in Nucleic Acid Therapeutics

Author : Michael J Gait

Publisher : Royal Society of Chemistry

Page : 566 pages

File Size : 32,25 MB

Release : 2019-02-11

Category : Science

ISBN : 1788012097

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Book Description

The sequencing of the human genome and subsequent elucidation of the molecular pathways that are important in the pathology of disease have provided unprecedented opportunities for the development of new therapeutics. Nucleic acid-based drugs have emerged in recent years to yield extremely promising candidates for drug therapy to a wide range of diseases. Advances in Nucleic Acid Therapeutics is a comprehensive review of the latest advances in the field, covering the background of the development of nucleic acids for therapeutic purposes to the array of drug development approaches currently being pursued using antisense, RNAi, aptamer, immune modulatory and other synthetic oligonucleotides. Nucleic acid therapeutics is a field that has been continually innovating to meet the challenges of drug discovery and development; bringing contributions together from leaders at the forefront of progress, this book depicts the many approaches currently being pursued in both academia and industry. A go-to volume for medicinal chemists, Advances in Nucleic Acid Therapeutics provides a broad overview of techniques of contemporary interest in drug discovery.



RNA Therapeutics

Author : Paloma H. Giangrande

Publisher : Academic Press

Page : 474 pages

File Size : 48,9 MB

Release : 2022-04-10

Category : Science

ISBN : 0128217391

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Book Description

RNA Therapeutics: The Evolving Landscape of RNA Therapeutics provides a comprehensive overview of RNA therapeutic modalities, from bench-to-bedside, with an emphasis on the increasingly impactful areas of gene therapy, oligonucleotide therapeutics, gene editing and delivery. International leaders in the field examine RNA-based therapeutics tools that have been developed to-date to modulate cellular processes such as transcription, translation and protein function. Approved RNA-based therapies and lessons learned from failed therapies are discussed in-depth, as are evolving advances in RNA biochemical analysis, and similar advances that are enabling clinical application of RNA-based therapies. Later sections discuss delivery technologies, remaining hurdles in research and translation, the therapy development process from the lab to the clinic, and novel RNA-based therapies currently in development. - Features leading experts in the field of RNA therapeutics, spanning all classes of RNA therapies - Provides a detailed examination of approved RNA therapies and lessons learned from failed therapeutics - Covers all aspects of therapeutic discovery and preclinical development, as well as clinical translation, manufacturing and regulatory aspects



Pharmaceutical Perspectives of Nucleic Acid-Based Therapy

Author : Ram I. Mahato

Publisher : CRC Press

Page : 521 pages

File Size : 16,5 MB

Release : 2002-06-27

Category : Medical

ISBN : 0203300963

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Book Description

Emphasizing its uses in cancer and cardiovascular and autoimmune diseases, Pharmaceutical Perspectives of Nucleic Acid-Based Therapy presents a comprehensive account of gene therapy, from development in the laboratory to clinical applications. Internationally acclaimed scientists discuss the potential use of lipids, peptides and polymers for the in



Therapeutic Oligonucleotides

Author : Jens Kurreck

Publisher : Royal Society of Chemistry

Page : 362 pages

File Size : 24,56 MB

Release : 2008

Category : Medical

ISBN : 0854041168

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Book Description

This book provides a compelling overall update on current status of RNA interference



Gene Therapy for Cancer

Author : Kelly K. Hunt

Publisher : Springer Science & Business Media

Page : 469 pages

File Size : 16,72 MB

Release : 2007-10-26

Category : Medical

ISBN : 159745222X

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Book Description

The three sections of this volume present currently available cancer gene therapy techniques. Part I describes the various aspects of gene delivery. In Part II, the contributors discuss strategies and targets for the treatment of cancer. Finally, in Part III, experts discuss the difficulties inherent in bringing gene therapy treatment for cancer to the clinic. This book will prove valuable as the volume of preclinical and clinical data continues to increase.



Nucleic Acid Biology and its Application in Human Diseases

Author : Subhrangsu Chatterjee

Publisher : Springer Nature

Page : 423 pages

File Size : 23,54 MB

Release : 2023-05-30

Category : Medical

ISBN : 9811985200

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Book Description

This book reviews the structure-function relationship of nucleic acids, their role in the pathophysiology of the diseases, and as therapeutic targets for human diseases. The chapters discuss the role of nucleic acids in inflammatory diseases, neurodegenerative diseases, and cancer. The book also describes recent advancements in nucleic acid-based therapy, the application of nucleic acids in diagnostics, in the development of nano-carriers, logic gates, and sensors. It explores the use of nucleic acids (RNA and DNA) as a unique and multifunctional platform for numerous applications, including therapeutics, diagnostics, nanodevices, and materials. It further examines the role of DNA methylation, histone modifiers and readers, chromatin remodelers, microRNAs, and other components of chromatin in the progression of cancer. The book also discusses the applications of nucleic acid as a vaccine and as a gene-editing tool. It also provides an overview of the clinical trials using genome editing platforms for disease treatment and the challenges in implementing the editing technology. Finally, the book elucidates a representative description of challenges associated with nucleic acid-mediated therapy. ​