Author : Joseph A. Beavo
Publisher : CRC Press
Page : 728 pages
File Size : 14,18 MB
Release : 2006-12-05
Category : Medical
ISBN : 1420020846
Since the last major compendium dedicated to cyclic nucleotide phosphodiesterases (PDEs) was published over 15 years ago, an enormous amount of progress has occurred in the field. There is great need for a centralized source for key information in this burgeoning and therapeutically important area of medical research. Cyclic Nucleotide Phosph
Author : Spiros Liras
Publisher : John Wiley & Sons
Page : 280 pages
File Size : 34,17 MB
Release : 2014-03-03
Category : Medical
ISBN : 3527682368
Written by the pioneers of Viagra, the first blockbuster PDE inhibitor drug. Beginning with a review of the first wave of phosphodiesterase (PDE) inhibitors, this book focuses on new and emerging PDE targets and their inhibitors. Drug development options for all major human PDE families are discussed and cover diverse therapeutic fields, such as neurological/psychiatric, cardiovascular/metabolic, pain, and allergy/respiratory diseases. Finally, emerging chemotherapeutic applications of PDE inhibitors against malaria and other tropical diseases are discussed.
Author : XiaoDong Cheng
Publisher : CRC Press
Page : 288 pages
File Size : 45,9 MB
Release : 2021-03-30
Category : Cellular signal transduction
ISBN : 9780367658809
Showcasing the recent progresses of the field, Cyclic Nucleotide Signaling covers the major tools and methodologies used in various areas of research. The majority of the chapters are protocol oriented, with the goal of providing clear directions for laboratory use. Students and investigators new to the field will find this book particularly informative, as will scientists already actively researching nucleotide signaling.
Author : Han-Ting Zhang
Publisher : Springer
Page : 475 pages
File Size : 39,71 MB
Release : 2017-09-26
Category : Medical
ISBN : 3319588117
PDEs are a family of enzymes that catalyze the hydrolysis of intracellular cyclic nucleotides. They are implicated in a number of disorders and dysfunctions and PDE inhibitors have already proven to be effective therapies for erectile dysfunction, COPD, and psoriatic arthritis. This family of enzymes also plays a role in diseases and disorders of the CNS such as depression, anxiety, schizophrenia, and Alzheimer's Disease. Unfortunately no effective PDE inhibitors have been developed for the treatment of these diseases. The proposed book will be a comprehensive overview of the current state of basic and translational research on PDE inhibitors written by internationally recognized experts. Authors will also discuss potential PDE subtypes and splice variants in the hopes that this will spur more creative approaches to PDE targeting drugs.
Author : Sharron H. Francis
Publisher : Springer Science & Business Media
Page : 531 pages
File Size : 15,61 MB
Release : 2011-06-21
Category : Medical
ISBN : 364217969X
Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that selectively target this class of enzymes. Novel characteristics of PDEs are viewed as unique opportunities to increase specificity and selectivity when designing novel compounds for certain therapeutic indications. This chapter provides a summary of the major concepts related to the design and use of PDE inhibitors.
Author : Nicholas J. Brandon
Publisher : John Wiley & Sons
Page : 429 pages
File Size : 30,68 MB
Release : 2014-03-07
Category : Medical
ISBN : 1118836308
This book reviews advances in understanding phosphodiesterases within the central nervous system and their therapeutic applications. A range of expert authors from both academia and industry describe these, then focus on the areas of greatest scientific and medical interest to provide more detailed coverage. Therapeutic and drug discovery applications are covered for diseases including Alzheimer's, Parkinson's, schizophrenia, erectile dysfunction, and spinal cord injuries. There is also a chapter on drug discovery tools such as in vitro assays and X-ray structures for medicinal chemistry studies.
Author : Rik Gijsbers
Publisher : Leuven University Press
Page : 146 pages
File Size : 34,15 MB
Release : 2003-09
Category : Science
ISBN : 9789058673008
"Ecto-nucleotidases, Extracellular nucleotides and their metabolism, Nucleotide Pyrophosphatase/Phosphodiesterase (NPPs), Mammalian NPP isforms, NPPs are modular proteins, Enzyme activities of NPPs, Functional diversity of NPPs, Aims and strategies, Materials and methods, Results and discussions, A family of NPP proteins, Characterization of the catalytic domain of NPPs, Characterization of the non-catalytic ectodomains of NPPs, NPP1 and the pathogenesis of insulin resistance, Conclusions and Perspectives."
Author : Claire Lugnier
Publisher : Springer Science & Business Media
Page : 327 pages
File Size : 42,8 MB
Release : 2008-02-04
Category : Science
ISBN : 1592598390
Research leaders in the PDE field describe new concepts and techniques for investigating the role of PDEs in orchestrating normal and pathophysiological responses. Presented in step-by-step detail, these readily reproducible methods allow the measurement of cyclic nucleotide variations in living cells, as well as their visualization in a spatio-temporal manner, the localization and characterization of their activities in tissues and living cells, and the assessment of targeted PDEs in creating specific tools and drugs.
Author : Sharron H. Francis
Publisher : Springer
Page : 522 pages
File Size : 46,82 MB
Release : 2011-08-02
Category : Medical
ISBN : 9783642179686
Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that selectively target this class of enzymes. Novel characteristics of PDEs are viewed as unique opportunities to increase specificity and selectivity when designing novel compounds for certain therapeutic indications. This chapter provides a summary of the major concepts related to the design and use of PDE inhibitors.
Author : J. Beavo
Publisher :
Page : 0 pages
File Size : 17,29 MB
Release : 1990
Category :
ISBN :
